Effectiveness Of 4 Psychotherapies During The Treatment Of Cocaine Dependent Patients

817 WordsMay 1, 20154 Pages
Crits-christoph et al10 designed a trial to determine the effectiveness of 4 psychotherapies in the treatment of cocaine-dependent patients. In this multicenter study, 487 patients were randomized into one of the four treatment groups: individual drug counseling (IDC) plus group drug counseling (GDC), CBT plus GDC, SE plus GDC or GDC alone. Intervention included a 6 month active phase of treatment and a 3 month booster phase and follow-up of 3 months. All treatment groups recorded significant improvements from baseline mean (SD) 30 days cocaine use of 10.4 (7.8) days (median, 8.0; range, 1-30; n=487) to 3.4 (6.5) days (median, 0; range, 0-30; n = 387) at 12 months. Among the four groups, IDC plus GDC was superior on the number of cocaine-use days and also on the Addiction Severity Index-Drug Use Composite score. The authors noted that despite the low average drug use found in in the IDC-treated patients during the 12 month trial, abstinence was not maintained in most patients as only 36%achieved 3 consecutive cocaine-free months. Discovering an effective pharmacotherapy for cocaine use disorder remains a top research priority nationally since there are currently no FDA approved medication for the treatment of cocaine dependence. While several classes of medications have shown some efficacy in some phase two clinical trials, none has been proven to show consistency and lasting efficacy. Recent progress in the understanding of the effect of cocaine on the
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