Effectiveness Of The Rotavirus Vaccine Essay

1878 WordsOct 3, 20148 Pages
Effectiveness of the rotavirus vaccine in New Zealand infants between 8 weeks and three years old Abstract Background. Rotavirus is a gastrointestinal illness characterized by vomiting, diarrhoea, stomach ache and a fever. Children less than three years old are particularly at risk of dehydration from the sudden vomiting and diarrhoea, which can require hospitalisation. A vaccine against rotavirus was recommended globally by WHO in 2009, and it has recently been approved into the New Zealand immunisation schedule. As yet there are no studies following the effectiveness of this vaccine since its introduction using New Zealand study subjects specifically. Methods. In this matched case control study, cases are infants between eight weeks and three years of age who will be seen in a participating ED with rotavirus, confirmed with a positive rotavirus antigen test, between November 2014 and November 2016 in New Zealand. For every case we will enrol 1 or 2 controls who are seen in the same ED without rotavirus and they will be matched for date of birth (within two weeks) and date of visit to ED (within two weeks). Vaccine effectiveness will be calculated by 1 minus the matched odds ratio, multiplied by 100 for the percentage. Aims To measure the effectiveness of the new rotavirus vaccine against Emergency Department attendance, or admission, for rotavirus in infants between 8 weeks and three years of age in New Zealand. To try and measure the effectiveness of the vaccine
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