Effectiveness Of The Treatment Before And After The Surgical Revascularization Intervention Procedures

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To analyze the effectiveness of the treatment before and after the surgical revascularization intervention procedures in PAD patients who may have microvascular dysfunction, we studied the change in oxygen concentration at the walls of capillaries. Oxygen transfer in a vascular network that is essential for the tissue metabolism takes place at the level of microvasculature and capillaries through convection and diffusion. Oxygen delivery or convective flow of oxygen to the capillaries and oxygen extraction or diffusive transport of oxygen from hemoglobin (Hb) to tissue cells are the two limiting factors associated with oxygen transfer in a vascular network (Pittman, 2000). In order to quantify the transfer rate of oxygen from capillaries to the surrounding tissues, micro-circulation in the vascular network was modeled in a virtual simulation software using the chemical reaction module. Two mechanisms associated with the oxygen transfer; oxygen from the blood is transferred to the inner wall through convection and from inner capillary wall to the surrounding tissue via diffusion phenomena, are shown in Figure 1. Microcirculation includes both delivery and extraction that is governed by the equation from Fick’s Principle (conservation of mass). 〖Q_(O_2 )〗^Diff= 〖Q_(O_2 )〗^Conv (upstream)-〖Q_(O_2 )〗^Conv (downstream) Equation 1 The inflow would be the blood pumped from the heart through arterioles and incoming flux of blood flow releases the blood cells with Hb

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