Effectiveness of Transtympanic Injections of N-acetylcysteine for the Prevention of Cisplatin-induced Ototoxicity

All kind of information about different vitamins that can cure tinnitus and can also is useful for human body to get rid of tinnitus forever not just temporarily.

Pure tone audiometry suggested the presence of otosclerosis in the right ear. SRT (50dB for the right ear and 30dB for the left ear) corresponds with the pure tone thresholds. WR scores for the right ear were 96% (85dB) and 100% (70dB) for the left ear, which are consistent with the CHL in the right ear and WNL in the left ear. Typanometry confirmed that finding by revealing a reduced compliance, which indicated less mobility of the tympanic membrane due to increased stiffness. These findings corresponded with the presence of Carhart’s notch at 2000Hz from the audiogram. The absence of OAEs in the right ear also confirmed the conductive component of hearing loss in the right ear due to otosclerosis. The audiology evaluation affirmed that the patient has a decrease in hearing for natural and speech sounds in the right

Otosclerosis is a disorder that is inherited that can cause loss of hearing because of lack

A condition of the middle ear and it mainly affects the stapes (tiny stirrup) bone is considered as otosclerosis. When the bones (ossicles) combine together into an immovable mass, and does not transmit sound as well as when they are more flexible. It can also affect the other ossicles, the malleus and incus, and the otic capsule as well. Otosclerosis can cause gradual hearing loss and severe inner pain of the ear. Hearing aids and surgery are the best treatments.

In terms of microsurgery excision, this procedure would be performed on tumors ranging from small to large sized, measuring less than 2 cm to greater than 4 cm (Lippincott Williams & Wilkins, Inc., 2007). The option of microsurgery is the oldest and best-studied treatment for Acoustic Neuroma. It appears to provide the best tumor control. According to The Hearing Journal (2007),

Similarly, allergies and benign tumors can cause hearing loss. Earwax can cause hearing troubles, which may or may not be corrected with removal services. If the eardrum has been ruptured, you will have difficulty hearing.

World Health Organization estimates that '84' million individuals will die of cancer between 2005 and 2015. Oral Mucositis is a frequently occurring and debilitating complication of chemotherapy. Consequently Oral Mucositis will result in malnutrition, fluid electrolyte imbalances, and different complications such as infection. In spite of large choice of prophylactic agents offered, there's very little consistency among institutions, and many commonly used interventions are not evidence-based. As well as, however Cryotherapy has shown some positive effects in preventing Mucositis, there are still some shortcomings for this intervention such as limited number of supporting studies which are predominantly designed on chemotherapy, for the above reasons . the researcher motivated to undertake this study. As ice cubes may be prepared promptly available and cheaper, individuals undergoing chemotherapy might effectively use this in their due course of therapy. Therefore, this study was conducted to evaluate the of Cryotherapy on incidence and severity of chemotherapy-induced Oral Mucositis and Oral Mucositis related pain in patients treated with combined chemotherapy (Fluorouracil and Leucovorin) “Not everything that is faced can be changed. But nothing can be changed until it is faced.” James

Shelby’s prognosis is very favorable if the cholesteatoma is promptly removed. Nevertheless, Shelby may experience permanent, moderate conductive hearing loss. On the other hand, the mortality rate for cholesteatomas is low, and according to Lazard et al. (2007), reoperation for this medical condition occurs in 5% of patients or

Without reconstruction the tympanic membrane perforation result in hearing loss, chronic otorrhea and cholesteatoma formation. (3)

Introduction: probably every human has once or even more heard sound that does not originate in the outside world. The sounds heard like: ringing, clicking, and roaring, buzzing sometimes even music or unclear voices. They may appear in one ear or both soft or loud, in low tones or high. They originate inside the head and they are known as tinnitus. Tinnitus can lead to a wide array of serious and minor disorders of the ear and of the body in general. Some motives are reasonably well understood, but most are not. Effective treatment has been established for some cases of tinnitus, but for most, effectiveness of treatment continues to be unpredictable. Tinnitus is not a disease. It is a symptom that can result from a number of underlying causes.

Analog – Analog hearing aids make the sound louder by converting the sound into electrical signals. Analog type of hearing aids can be adjusted for different environments. You can adjust it if you are in a room or in a crowded place like mall.

Cisplatin is a platinum-based chemotherapeutic agent with proven efficacy against solid tumors. However, the clinical use of cisplatin is limited by the development of permanent hearing loss in cancer patients. There is currently no drug approved by the US Food and Drug Administration for cisplatin-induced hearing loss (1, 2). Multiple studies have shown that cisplatin profoundly damages outer hair cells (OHCs) present in the hook region, basal and middle turns of the cochlea (3, 4) with relative sparing of inner hair cells (IHCs) in these regions. Other regions of the cochlea such as the spiral ligament (SL), stria vascularis (SV) and spiral ganglion neuron (SGN) are also susceptible to cisplatin-induced damage (5-9).

Fourteen had undergone prior placement of 1 or more sets of tympanostomy tubes and 2 had undergone tympanoplasties (no subjects reported a history of mastoidectomy). As shown in Figure 2, approximately 60% (14 of the 24 subjects) of all affected adults with complete bone conduction data had at least 2 thresholds above the 95th percentile or, in the case of 8000 Hz, above the 90th percentile. 2 Analysis revealed no statistically significant correlation between the number of episodes of otitis

Cisplatin is a chemotherapeutic agent used as a part of combination therapy in the treatment of germ cell tumors. Beside the huge benefit of this combination, a big problem exists. Cisplatin has common side effects which are sever nausea and vomiting. In germ cell tumors, the combination is used for five days so, it was noticed that the patients are suffering from nausea and vomiting during the treatment period and it tends to be milder at the end of these 5 days. (5)

Introduction: Otitis media is an inflammation of the middle ear cleft without reference to etiology or pathogenesis. Chronic suppurative otitis media (CSOM) is a destructive disease with irreversible sequelae and can proceed to serious intra and or extra cranial complications. For the management of CSOM and for the ENT surgeon to make the discharging ear dry for better results of surgical procedures like myringoplasty and ossiculoplasty study of bacteriology and antibiotic sensitivity is necessary.