Effects Of Obesity On The United States And Worldwide

2003 Words9 Pages
Research Strategy A. Significance and Background Obesity is a major public health concern in the United States and worldwide. Recent data suggest that more than 70% of the U.S. adults 20 years or older are overweight or obese (CDC 2016, CDC 2015). Obesity is associated with numerous serious health sequelae, including cardio- and neuro- vascular diseases, diabetes, and several types of cancer and incurs substantial medical costs (CDC 2015). Given the seriousness of the public health concern, there is great interest in the identification and mitigation of potential causes of obesity. As such, obesogenic environmental contaminants with widespread exposure and biological persistence is of great concern. Persistent organic pollutants (POPs) have been a public health and environmental concern for many years given their persistence in the environment, tendency to bioaccumulate, and toxic, carcinogenic, and endocrine-disrupting potentials (Bonefeld-Jorgensen 2014). Perfluoroalkyl Chemicals (PFCs) is one such family, chemically characterised by a fluorinated linear carbon chain with a hydrophilic head (Volkel 2008). Due to its stability, amphiphilicity, and non-flammability (Lau 2007, Kotthoff 2015), PFCs are commonly used to aid the industrial production of textiles, food packages, and cookware (Kotthoff 2015, Humblet 2014). PFCs can remain in the environment and bioconcentrate in animals (Lau 2007). PFCs are metabolic products from parent compounds such as fluorotelomer alcohol and
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