Effects Of Oral Nifedipine On The Control Of Hypertension During Pregnancy

1398 Words Dec 1st, 2014 6 Pages
Few studies over the past years have compared the effects of oral nifedipine to intravenous labetalol for the control of hypertension during pregnancy. Shekhar et al., conducted a randomized, double-blinded placebo-controlled trial, to compare the effectiveness of orally administered nifedipine and intravenously administered labetalol for acute blood pressure control of hypertensive emergency in pregnancy.4 The study was conducted between October 2012 to April 2013 in the labor ward of the department of Obestrics and Gynecology of Dr. Rajendra Prasad, Government Medical College and Hospital, Tanda, Kangra, India. Women were eligible for inclusion if they were 18 to 45 years old, at 24 weeks of gestation or more, a heart rate between 60 beats or more and fewer than 120 beats per minute, and had a reassuring fetal heart rate. Key exclusion criteria included exposure to any antihypertensive medication within the past 24 hours and non-pregnancy related hypertension. The randomization sequence was computer-generated in blocks of 4 or 8.4 A flat 10 mg-dosing regimen of oral nifidepine in up to 5 doses was given. Intravenous placebo saline injection or intravenous labetalol injection in escalating doses of 20, 40, 80, 80, 80 mg and placebo tablet was administered every 20 minutes until a target blood pressure of 150 mmHg systolic and 100 mmHg diastolic or lower was achieved. Participants were exposed to study medications that were placed in sequentially numbered sealed envelopes.…
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