Objective: There are some studies about the good effects of herbal drugs on blood glucose . This clinical trial was designed to evaluate the synergism effect of Peganum harmala,Quercus infectoria,Vaccinium myrtillus, Citrullos colocynthis, Securigera securidaca with different nature on blood glucose . Methods: Twenty qualified type 2 diabetic patients were enrolled in this cross over double- blinded clinical trial for receiving two months drug and also two months placebo. The subjects divided into two groups randomly. One group received drug and the other group placebo for 8 weeks at first. After one week washout, the drug and placebo were replaced for the next 8 weeks. T-Test and Chi-square were used for the comparison of variables between two groups. The statistical significance was recognized at P<0.05. Results: After two months intervention, mean fasting blood glucose was 135±27.1 and 139±36.8 mg/dl, (p=0.6), and mean glycosylated hemoglobin was 6.5±0.75 and 6.6±0.97 percent, with drug and placebo usage, respectively (p=0.5). Twenty five percent of patients after drug and 20% after placebo consumption had more than 0.5% reduction in HbA1C (p=0.5). The mean HOMA IR index, after two months intervention with drug or placebo, was 2.9±1.95 and 3.9±1.97, respectively (p=0.05). Conclusion: According to the present study, low dose combination of Peganum harmala, Quercus infectoria, Vaccinium myrtillus, Citrullos colocynthis, Securigera securidaca(125mg Vaccinium myrtillus,
The study showed that the benefits of glucose reduction did not accrue for several years, and despite achieving statistical significance, the absolute risk reduction from intensive glycaemic control was small, with a reduction of 5 events over 10 years, and a small differential HbA1c between the conventional and intensive groups. Furthermore, due to the progressive nature of the disease, increasing combinations of oral and insulin drug therapy were introduced over to time to maintain the tight glycaemic control, therefore providing greater variability and a limited scope of comparison for statistical data on the efficacy of individual agents used amongst the patient cohorts.(King, Peacock, and Donnelly, 1999). This has raised further questions for clinicians in assessing how worthwhile are the benefits achieved with tighter glycaemic control, and how can targets be achieved in routine practice? It is not always clinically acceptable to maintain intensive glycaemic control, for example with the frail and elderly, or those with existing severe co-morbidities or complications. The Diabetes Control and Complications Trial follow up study reported that patients who achieved an average HbA1c value of 53mmol/mol had better outcomes after 20 years of follow-up than the control group (who had an average HbA1c of 75 mmol/mol), irrespective of
Diabetes can be treated in three basic ways: by diet, by diet in conjunction with tablets, or diet in conjunction with insulin. Diet serves as an initial control for non-urgent patients. If a person’s diet will have a major effect on glycaemic control, it does so reasonably quickly, within a few weeks of changing
The study had an overall total of 1150 participants. Although there were many participants to begin with, they did not provide all of the feedback the researchers had requested. This resulted in the expulsion of their participation, so their results were not included in the final reports of the study. The number of patients that did provide the essential information added up to a total of 901. The profile for a participant was a patients diagnosed with Type 2 diabetes in the last 6 months, but has been diagnosed no more than 10 years ago. They had to be between 35-70 years of age. Their BMI had to be more or less than 24 kg/m2 and have an HbA1c more or less than 6.5%. They also had to have treatment with a diet or oral glucose lowering medication. Those needing insulin shots, had been diagnosed with chronic diseases, or had a change in diet or lifestyle 3 months prior to the study were not included in the overall
Everybody knows that obesity is a big factor in developing type-2 diabetes, and that part of coping with this metabolic disorder is lifestyle change. If blood glucose does not go down, then medicines are introduced. Some type-2 diabetics even have to administer insulin in order to keep their blood glucose levels
1 January 2017. The purpose of this source is for general scientific research and understanding diabetes. This gives the view on ongoing research, equipment modifications, changes in governmental regulations and the constant flow of information relating to the use of medicines, equipment and
Furthermore, with the pharma logical treatments included in this article for the treatment of Type 2 Diabetes, many individuals will be prevented from developing CVD complications. Studies have shown the importance of patients being compliant with treatment leading to positive health outcomes. With the continued care given to these patients with Type 2 Diabetes many are able to have healthier lifestyles
The desired goals to be achieved are as follows: to control fasting blood glucose levels to less than 126 mg/dl within 2 weeks, and to reduce HbA1C from 8.5 to s tolerance of Metformin and after 3 months to assess A1C, weight, and renal function (CrCl) and then every clinical visit (3 months). Follow up appointments should be scheduled with a nutritionist, Podiatrist, and ophthalmologist. ED should receive education about the
The results of this intervention resulted in significant reduction in the HbA1c levels. The mean levels of HbA1c in the immediate intervention group went from 8.31% to 7.68% in 3 months and for the delayed
Diabetes continues to be a growing problem for the United States population especially type 2 diabetes, which “accounts for about 90% to 95% of all diagnosed cases of diabetes”(Center for Disease Control and Prevention (CDC), 2014). Type 2 diabetes, formally known as adult onset diabetes, is defined as a “disorder of insulin resistance in which the cells primarily within the muscle, liver, and fat tissue do not use insulin properly. As the need for insulin rises the cells in the pancreas gradually lose the ability to produce enough hormone”(CDC, 2014). Diabetes as a whole affects about “9.3% of the US population or 29.1 million people” (American Diabetes Association (ADA), 2014; CDC, 2014). Despite the high prevalence of the disease, it is only going to continue to grow if nothing is done to correct the problem. The “United States spent an estimated $245 billion on diabetes in 2012” (ADA, 2014; CDC, 2014). This outrageous number and the drastic impact diabetes has on health should emphasis the need to reduce the diabetic population in the future.
This is a randomized control study; participants were randomly separated into a control group and an experimental group. Participants consisted of 48 insulin dependent individuals. There was baseline testing that consisted of a blood test measuring hemoglobin A1C (HbA1C), fasting blood glucose (FBG), triglycerides, and high and low density lipoprotein cholesterol. The experimental group received an intervention by using an electronic program geared for diabetics for 12 weeks. The electronic program provided access to answers for any questions an individual may have, a healthcare team, and educational resources. After the 12 weeks were complete, blood tests were repeated for both groups.
The primary outcome that will be studied is the blood glucose levels in patients. Blood glucose tests measure the amount of sugar in a sample of blood and is the main tool to check for diabetes control. This will be analyzed in two ways. The first one will be fasting blood glucose levels that patients recall for the previous weeks and that will be informed to the doctor during their appointment. This information will be obtained during the follow-up visits to the doctor that will happen every 3 months for 12 months. The other way it will be analyzed is through the Hemoglobin A1c blood test for a blood sample provided during the doctor’s appointment, which will also occur during the baseline visit and the four 3-month follow-up
The evidence-based practice should be the force behind changes in medical and nursing practice especially when it is advantageous to patient's health. Moreover, this principle should always be the first requirement despite the financial hurdles we face these days. With that in mind, one of the obstacles which we are trying to overcome in my department is for the leaders to realize that treating diabetic patients with GLP-1 drugs has been proven to be cost-effective while providing greatest HbA1c and weight reductions comparing to other hypoglycemic agents ( ). Besides, those patients would ultimately have higher life expectancy and less microvascular and macrovascular complications leading to considerably improved lifestyle. Although our case
There is growing concern that intense glucose lowering or the use of certain agents may be associated with adverse cardiovascular outcomes.
Pharmacological interventions used to improve glucose control include both oral glucose lowering agents and injectables including glucose like peptide & insulin. Apart from insulin the choice of available pharmacological interventions to treat diabetics has expanded rapidly over the past decade. Till date, the efficacy & safety of these therapies have not been well documented in people with diabetics & CKD.
Herbal medicines are great alternative for commercially manufactured medicines available in the market. The major reason why herbal medicine differ from modern medicine is because they are produced with 100% natural content. Therefore the plant extract has all the medicinal values that are as effective as modern medicine. Commercially prepared drugs show results quickly but have numerous side effects. However herbal medicines don’t show any side