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Effects of Herbal Drugs on Blood Glucose

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Objective: There are some studies about the good effects of herbal drugs on blood glucose . This clinical trial was designed to evaluate the synergism effect of Peganum harmala,Quercus infectoria,Vaccinium myrtillus, Citrullos colocynthis, Securigera securidaca with different nature on blood glucose . Methods: Twenty qualified type 2 diabetic patients were enrolled in this cross over double- blinded clinical trial for receiving two months drug and also two months placebo. The subjects divided into two groups randomly. One group received drug and the other group placebo for 8 weeks at first. After one week washout, the drug and placebo were replaced for the next 8 weeks. T-Test and Chi-square were used for the comparison of variables between two groups. The statistical significance was recognized at P<0.05. Results: After two months intervention, mean fasting blood glucose was 135±27.1 and 139±36.8 mg/dl, (p=0.6), and mean glycosylated hemoglobin was 6.5±0.75 and 6.6±0.97 percent, with drug and placebo usage, respectively (p=0.5). Twenty five percent of patients after drug and 20% after placebo consumption had more than 0.5% reduction in HbA1C (p=0.5). The mean HOMA IR index, after two months intervention with drug or placebo, was 2.9±1.95 and 3.9±1.97, respectively (p=0.05). Conclusion: According to the present study, low dose combination of Peganum harmala, Quercus infectoria, Vaccinium myrtillus, Citrullos colocynthis, Securigera securidaca(125mg Vaccinium myrtillus,

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