Lab 28B: Endocrine System Physiology Computer Simulation Introduction The endocrine system is the second greatest control system of the body and has many effects on the tissues and organs. The thyroid gland, which is a part of the endocrine system, releases a hormone that maintains metabolism. This hormone is thyroxine. Thyroxine production is controlled by thyroid stimulating hormone, which is released by the pituitary gland. TSH stimulates the thyroid gland to produce thyroxine. In this experiment, the effects of TSH and thyoxine on metabolic rate are investigated. Estrogen is a hormone produced by the ovaries that helps the uterus to develop. The removal of the ovaries eliminates the source of estrogen and the uterus …show more content…
With TSH Normal Rat Thyroidextomized Rat Hypophysectomized Rat Weight 249.7 244.4 245.8 ml O2 in 1min. 7.5 6.0 7.0 ml O2 in 1 hour 450.0 360.0 420.0 Metabolic Rate 1802.2 1473.0 1708.7 Experiment 5: Hormone Replacement Therapy The uterus of the rat that received injections of estrogen was found to weigh more than that of the rat that received injections of saline. Rat Elapsed Days # Saline injections # Estrogen injections Weight of Uterus Control 7 7 0 .1073 gms Experimental 7 0 7 .6681 gms Experiment 7: Comparing Glucose Levels Before and After Insulin Injection Test Tube Opt Density Glucose Insulin Saline Alloxan 1 normal .62 87 No Yes No 2 alloxan .87 129 No No Yes 3 nor/insulin .62 87 Yes Yes No 4 all/insulin .68 96 Yes No Yes Discussion and Conclusions The results for the baseline metabolic rate were as expected. The metabolic rates of the Tx and the Hypox rat were lower than the metabolic rate of the normal rat. The Tx rat could not produce thyroxine because it had no thyroid gland. The Hypox rat could not produce TSH which stimulates the thyroid to produce thyroxin. The results of the thyroxine metabolic rate were as expected. The injection of thyroxine increased the metabolic rate for all rats. This is understandable as thyroxine is the most important hormone in maintaining metabolism. The injection provided the Tx rat with a source of thyroxine in place
You answered: 1536.6 ml O2/kg/hr 3h. Calculate the oxygen consumption per hour for this rat using the following equation. ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour Enter the oxygen consumption per hour in the field below and then click Submit to display your results in the grid. You answered: 384 ml O2/hr 3i. Now that you have calculated the oxygen consumption per hour for this rat, you can calculate the metabolic rate per kilogram of body weight with the following equation (note that you need to convert the weight data from grams to kilograms to use this equation). Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr Enter the metabolic rate in the field below and then click Submit to display your results in the grid. You answered: 1573.8 ml O2/kg/hr Judging from their basal metabolic rates (an indicator of thyroid function), categorize the rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal, thyroid levels; BMR = 1650-1750), or hyperthryoid (high thyroid
The endocrine system includes of specific tissues and glands which secrete chemical messengers to the body called hormones. The glands are aided by the nervous system and chemical receptors in the blood and other hormones produced by other glands. Hormones regulate many functions of the body such as cellular metabolism, reproduction, sugar and mineral homeostasis and digestion.
Laboratory Report/ Miranda Tefft/ Homeostatic Imbalances of Thyroid Function/ Aline Potvin/ 11.18.2014/ Page [2] of [3]
of Thyroxine to T3 in the tissues). After 2 months of treatment, her TSH levels increased by 371.15% and her Thyroxine levels
Week 3 – LOM Assignment The thyroid is responsible for taking iodine and converting it into thyroid hormones which are released into the blood stream and transported throughout the body where they control metabolism.1 The thyroid is a vital part of the human body as every cell in the body depends on it for metabolic regulation. Too much or too little thyroid hormone secretion can result in hyperthyroidism or hypothyroidism. Hyperthyroidism is caused when the thyroid secretes too many thyroid hormones. Hyperthyroidism causes a rapid heart rate, elevated blood pressure and tremors. Other symptoms include increased nervousness, inability to concentrate, weakness, restlessness, difficulty sleeping, frequent bowel movements, weight loss and irregular
Exercise 4: Endocrine System Physiology: Activity 1: Metabolism and Thyroid Hormone Lab Report Pre-lab Quiz Results You scored 100% by answering 6 out of 6 questions correctly. 1. Which of the following statements about metabolism is false? You correctly answered: d. All of the energy from metabolism is ultimately stored in the chemical bonds of ATP. 2. Thyroxine is You correctly answered: c. the most important hormone for maintaining the metabolic rate and body temperature. 3. Thyroid-stimulating hormone (TSH) is You correctly answered: b. produced in the pituitary gland. 4. An injection of TSH to an otherwise normal animal will cause which of the following? You correctly answered: d. goiter development 5. Thyrotropin-releasing hormone
O B J E C T I V E S 1. To define the following terms: metabolism, hormone replacement therapy, type 1 diabetes, type 2 diabetes, and glucose standard curve. 2. To explain the role of thyroxine in maintaining an animal’s metabolic rate. 3. To explain the effects of thyroid-stimulating hormone on an animal’s metabolic rate. 4. To understand how estrogen affects bone density. 5. To explain how hormone replacement therapy works. 6. To explain how fasting plasma glucose is used to diagnose diabetes. 7. To understand how levels of cortisol and ACTH can be used to diagnose endocrine diseases.
Most T3 and T4 released into the bloodstream are bound to proteins. Only the "free" component is biologically active and it is this component which decides the manifestations of thyrotoxicosis. The hormones exert their effects mainly by binding to nuclear receptors in cells to affect expression of genes.
Incidentally, there are actually two compounds made in the thyroid that are called thyroid hormone. The most abundant is T4, also known as thyroxine, which is then converted to T3, or triiodothyronine. T3 is the active form that produces the effects on metabolism.
The thyroid gland is the gland that makes and stores hormones that help regulate the heart rate, blood pressure, body temperature, and metabolism. Thyroid hormones are essential for the function of every cell in the body. They help regulate growth and the rate of chemical reactions in the body. Thyroid hormones also help children grow and develop. The thyroid gland is located in the lower part of the neck, below the Adam's apple, wrapped around the trachea. It has the shape of a butterfly with two lobes attached to one another by a middle part called the isthmus. The thyroid uses iodine, a mineral found in some foods and in iodized salt, to make its hormones. The two most important thyroid hormones are thyroxine (T4) and triiodothyronine
I would like to first begin by saying a person’s metabolic rate depends on how much thyroxine is produced in the thyroid. Also, there are two types of metabolism, anabolism and catabolism. “Anabolism turns smaller molecules into large molecules, such as fat, protein, and carbohydrates. Catabolism is the process of breaking down fat, protein, and carbs for energy” (newhealthadvisor.com). The pancreas plays a key role in determining how much glucose was consumed and therefore if insulin should be released for anabolism. So the pancreas is the deciding factor on whether or not metabolism will be anabolic or catabolic. All chemical reactions in the body are categorized as metabolism. To be able to perform metabolism, the body needs an adequate supply of oxygen and nutrients.
Starting during prenatal development and continuing throughout life, thyroid hormones pay an important role in the cardiovascular system, the relationship in which has been seen to change in the case of thyroid dysfunction. The relationship between the heart and the thyroid has been demonstrated through a series of experimental and clinical studies and the results determined that in the case of hypothyroidism parameters such as blood volume and heart rate have been seen to decrease from 100% and 72-84bpm to 84.5 % and 60-80bpm respectively. The regular measurements of both the patients cardiac output and systemic vascular resistance have also been seen to change, shifting from 4.0-6.0 L/min and 1500-1700 dyn·sec/cm-5 to <4.5 L/min and 2100-2700
The Thyroid Gland - The thyroid gland produces hormones which regulate the body's metabolic rate as well as heart and digestive function, muscle control, brain development and bone maintenance. Its correct functioning depends on having a good supply of iodine from the diet.
THs exert a wide series of effects acting upon virtually all tissues in the organism( Venditti ,et al.,2003). The actions derived from the THs are not well known and seem to differ significantly. For instance, diiodothyronin (T2) produces metabolic effects similar to those of T3 (Lanni,et al.,1996) whereas thyronamines oppose its actions (Venditti, et al.,2011), at least at the mitochondrial level .The known actions of the THs can be grossly classified in two general processes: regulation of growth and development, and metabolism regulation. The metabolic effects of THs are
The thyroid gland is found in the front of the neck and produces two main hormones. The hormones are called thuroxine (T4) and Triiodothyronine (T3). Together these hormones regulate the body’s metabolism by increasing energy use in cells, regulate growth and development, help to maintain body temperature and aid in oxygen consumption. These two hormones are regulated by hormones produced by the hypothalamus and pituitary gland. The hypothalamus senses changes in body’s metabolic rate and releases a hormone known as thyropin-releasing hormone (TRH). This hormone then flows through connecting vessels to the pituitary gland which signals it to release another hormone. This hormone is known as thyroid-stimulating hormone (TSH). TSH then makes