Enoxoparin Sodium Injection ( Low Molecular Weight Heparin )

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Lovenox (Enoxoparin Sodium Injection) Classification: Anticogaulant (Low Molecular Weight Heparin)
MW: 1134.899 g/mol pKa1 -2.4 pKa2 -4.4
Chemical Formula: C26H42N2O37S5 IUPAC name 6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid Description
Enoxaparin is a highly acidic mucopolysaccharide. It is an anticoagulant drug that is used primarily for prophylaxis of deep vein thrombosis (DVT) or for patients that exhibit pulmonary embolism (PE) that have underwent specific surgery. Enoxaparin functions as a serine-type endopeptidase inhibitor and targets antithrombin-III. It binds to it and creates a vertex that irreversibly inactivates clotting factor Xa. Enoxaparin binding to antithrombin-III also accelerates the activity of antithrombin-III which is a serine protease inhibitor that modulates the activation of blood coagulation. Enoxaparin inhibits the production of prothrombin to thrombin. Antithrombin-III inhibits thrombin, factors Xa, IXa, and XIa, as well as matripatase-3/TMPRSS7. With the presence of enoxaparin its inhibitory activity is increased greatly. With the Xa being catalyzed by the attachment of enoxaparin, the translation of prothrombin to thrombin is decreased.

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