Environmental Factors Causing Parkinson's Disease

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 Environmental factors – There is some evidence that presence of toxins and harmful environmental agents may grow the risk of developing Parkinson’s later in life; however the possibility is very less.
Certain chemicals believed to responsible for Parkinson’s are –
 Fungicides
 Insecticides
 Herbicides
 Agent Orange
In rural areas drinking well water and intake of manganese are also associated with Parkinson’s.
Metals like lead and iron are also suspected to be linked with Parkinson’s disease. According to few studies individuals with excessive levels of lead in their body had more risk of acquiring Parkinson’s disease. Iron has also been indicated in the etiology of Parkinson’s.
However, not all people exposed to these harmful environmental
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Scientists are clueless why lewy bodies are formed and what is their role in Parkinson’s. But clumps of lewy bodies’ results in brain degeneration, causing problems with motor coordination in people affected with Parkinson’s disease.

 Age factor – Growing age is considered one of the leading factors for the emergence of Parkinson’s disease. Majority cases of Parkinson’s occur in the middle to late years of life, mainly above 60 years of age. Rarely this disease is seen in younger individuals. Some experts presume that brain and dopamine function deteriorates from environmental and genetic factors as the body
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The precise role of the protein deposits is still not known. Researchers are working on vaccine development to decrease or prevent the multiplication of alpha-synuclein.
 Free Radicals and Mitochondria

According to research mitochondria can lead to the development of Parkinson’s disease. Mitochondria are the energy-producing constituents of cell and are the principal sources of free radicals. Free radicals are molecules that harm proteins, membranes, DNA and other parts of the cell. This damage is known as oxidative stress. Changes in brain cells due to oxidative stress such as free radical damage to DNA, fats, proteins have been seen in patients with Parkinson’s disease. Clinical studies are now going on to observe whether factors thought to boost energy metabolism and reduce oxidative stress are helpful in the treatment of Parkinson’s disease. Recent studies have shown that mutations in genes associated with Parkinson’s disease leads to impairment of mitochondria.
 Decreased levels of Vitamin B 12
Scientists observed that mice with a deficiency of vitamin B developed acute Parkinson's symptoms, while those with normal levels of this vitamin did
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