Environmental and Genetic Factors that Causes Celiac Disease

When the gluten reaches the small intestine, it activates the immune system to attack the intestine lining. Destroying the finger like projections called Villi which are involved in the absorption of the nutrients.

Celiac disease is a fairly common disease but is not very well known. Celiac disease, or celiac sprue, is a digestive condition triggered by consumption of the protein gluten (Hill, Clinical manifestations and diagnosis of celiac disease in children, 2011). Gluten is a protein found in wheat, barley, rye, and oats. People with celiac disease who eat foods containing gluten experience an immune reaction in their small intestines, causing damage to the inner surface of the small intestine and an inability to absorb certain nutrients (Hill, Clinical manifestations and diagnosis of celiac disease in children, 2011).

Celiac disease is an autoimmune disease triggered by ingestion, of gluten-containing foods. The disease results from inappropriate T cells immune response against gliadin in genetically predisposed people. Individuals with this disorder have high levels of antibodies to a variety of antigens. The resulting immune response produces a strong inflammatory reaction that results in loss of absorptive villi from the small intestine. After the subsequent lesions are widespread, they may weaken absorption of macronutrients and micronutrients. Small bowel involvement

Celiac disease is primarily a digestive condition triggered by consumption of the protein gluten resulting in an immune reaction in the small intestine, which leads to inability to absorb certain

This article is focused around Celiac Disease and how the autoimmune disorder affects athletes that suffer from this disease. This article goes over several difficulties that come along with Celiac Disease (CD) such as, Etiology, exercise prescription, and diet management. The purpose of this article is to inform athletes with CD and even healthcare professionals that sometimes the signs are not clear and professionals have to take the correct steps and test to find the appropriate solution. The summary of this article would have to be that the number of CD cases are increasing rapidly throughout the United States. And with the rapid growth of athletes with CD, healthcare professionals had to become more educated with this disease because it was so hard to spot in individuals.

Celiac disease is different from other food allergies. Celiac disease is where the small intestine is diseased. A person with celiac accidentally consumes something with gluten will be more likely to have intestinal problems such as constipation, gas, and diarrhea (Liu, Dong, Barón, Taki, Norris, Frohnert, & Rewers 2017). Symptoms of the condition include abdominal pain, nausea, anemia, heartburn, weight loss, mouth ulcers, and headaches.

Did you know that if you have celiac diease it can stun your growth? There's no cure for celiac disease — but following a strict gluten-free diet can help manage symptoms and promote intestinal healing. If you have celiac disease, eating gluten triggers an immune response in your small intestine. Over time, this reaction produces inflammation that damages the small intestine's lining and prevents absorption of some nutrients (malabsorption). When people with celiac disease eat gluten (a protein found in wheat, rye and barley), their body mounts an immune response that attacks the small intestine. These attacks lead to damage on the villi, small fingerlike projections that line the small intestine, that promote nutrient absorption. When the

Celiac disease is often confused for an allergic illness because (like an allergy) it requires a foreign substance to trigger it. Usually diagnosed by a gastroenterologist, it is a digestive disease that can cause serious complications, including malnutrition and intestinal damage, if left untreated. Individuals with celiac disease must avoid gluten, found in wheat, rye, barley and sometimes oats. There seems to be a genetic predisposition to developing celiac disease, however not all people with a family history of celiac disease develop the condition. There is another reason, yet unknown, why the autoimmune response

Celiac sprue disease is an autoimmune disorder in which the body’s immune cells attack its own intestinal villi in response to digested gluten from one’s diet, leading to the inability to sufficiently absorb nutrients and vitamins needed to maintain good health. Its symptoms include a wide span of gastrointestinal issues such as diarrhea, nausea/vomiting, lactose intolerance, indigestion/bloating, and sudden weight loss; there are also several chronic symptoms such as fatigue, nosebleeds, and even seizures. There is not a cure for this disease. The best way to prevent it and allow your intestines to heal is to lead a life-long gluten-free diet. Additional vitamins and supplements may also be prescribed by doctors to ensure people with this

Crohn’s disease (CD) is a life-long, chronic, idiopathic inflammatory condition of the intestines that is characterized by frequent symptomatic relapse and remission. It involves inflammation and ulceration of various regions of the gastrointestinal tract (GI tract) lining, which often extends deep into the layers of the affected areas. The associated inflammation and ulceration of the disease affects various segments of the intestines with unaffected bowel occuring between the diseased areas. CD can involve any area of the GI tract, ranging from the mouth to the anus. However, it frequently affects the jejunum, terminal ileum (regional enteritis), and proximal colon (granulomatous colitis) (Schub, 2016).

The first risk factor being in people with dysfunction of the autonomic nervous system. A change or disorder in the autonomic nervous system such as low vagal tone or increased sympathetic responses can alter the visceral response.1 Many symptoms outside the intestinal tract and frequent GI problems can be identified as an abnormal autonomic response such as chronic fatigue or fibromyalgia. Other risk factors include smoking and stress in life including poor coping mechanisms for stress. CD is often accompanied but probably not caused by other autoimmune disorders such as lupus erthematosus and fibromyalgia.1 A genetic marker has not been identified but Crohn’s disease frequently occurs with a family history of the disease. Recent research has identified multiple correlations between certain genetic markers and CD but a definitive connection has not been made.

Other factors increase your chances of having the disease. Sometimes celiac symptoms are misdiagnosed. Irritable Bowel Syndrome (IBS) is one of the conditions most commonly confused with CD. Doctors will often diagnose their patients with IBS when in fact celiac is the culprit. IBS symptoms include abdominal pain, bloating, diarrhea and constipation, which are identical to celiac symptoms. The difference is that while celiac damages the small intestine, IBS attacks the large intestine, for reasons still unknown. IBS sufferers should be tested, since their chances of having CD increases greatly (Lapid, N April 20, 2009). Consider the case of

Celiac’s disease is a digestive and autoimmune disorder that happens when you eat foods that contain gluten. An autoimmune system happens when your body mistakenly attacks its own tissues, because it thinks it’s bad (http://www.news-medical.net/health/What-is-Autoimmune-Disease.aspx). So, your immune system reacts to the gluten, as it harms something called villi, which is in your small intestine (http://www.webmd.com/digestive-disorders/celiac-disease/celiac-disease). Villi are lined all around your intestine, and they are very important. They look like little, tiny hairs, and they absorb all of the nutrients you need! Because they get damaged, though, nutrients can’t be absorbed, and you may end up being malnourished, even if you eat a lot!

Diagnostic tools were developed to conduct various experiments using the new “era” of Coeliac Disease epidemiology. The amount of cases that have had viable samples have been shown in various locations around the world and with our technological advancement, have been able to give more detailed analysis then past observations. The source explains the data reviewed data on the frequency of CD in Middle Eastern countries that argue the theory that there is a possible opposite relationship between CD ancestry and the length of time since the start of

What causes the immune system to malfunction is unknown. Therefore, there is no reliable way to prevent developing an autoimmune disease. There is a possibility that hormones may play a part in stimulating autoimmune diseases. Autoimmune diseases may even have an inherited element because a good number of autoimmune diseases likely run in families. This means that a person is seemingly likely to develop the disease if that person has a close relative with that disease. For a few autoimmune diseases, this familial possibility remains small. (Franz, 2006, Laberge, Davidson, 2007, Schwartz, 2007, Dugdale, 2009, Wrong Diagnosis, 2000).