Epidemiology Of Chagas Disease

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Chagas disease is an endemic infection in Latin America caused by the parasite Trypanosoma cruzi. Nowadays, it affects millions of people worldwide including thousands in Europe and Oceania. Megacolon, that represents the most frequent complication of the digestive chronic form, happens due to lesions of the enteric nervous system, followed by motility disorders. The neuronal lesions seems to initiate right in the acute phase and persist for a long period during the chronic phase, being that the mechanisms involved on such process are still debated. Among the cells of the immune system possibly involved in this pathological process, we emphasize the mast cell (MC), due to its well known role in the bidirectional communication between the immune
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