Epidermolysis Bullosa also known as E.B. is generally an inherited connective tissue disease. This disease is evident at birth or soon there after. It causes large fluid filled blisters, in the skin and mucosal membranes. Chaffing or even increase in room temperature may cause these blisters to form. E.B. affects an estimated 50 in 1 million live births. The disease has been known to affect every racial and ethnic group and is found in both males and females all over the world. The disease has been seen in a wide variety of forms from mild to lethal form involving some organs. Epidermolysis Bullosa is the result of a mutation in the keratin or collagen gene. There are three layers of skin epidermis, dermis and the subcutaneous …show more content…
These are all very important in determining whether or not the patient has Epidermolysis Bullosa or if it is a different skin disease. Knowledge of family history is also key because E.B. is mostly inherited. The inheritance pattern may vary from dominant to recessive. The recessive form (meaning both parents transmit the gene to a child) tends to be worse. Although the dominant form means one parent carries the dominant gene enabling them to pass it on to their child. Diagnosing correctly must also take into account the symptoms. There are many complications that can happen with any one of the varieties of Epidermolysis Bullosa. The symptoms of a patient with Epidermolysis Bullosa may vary depending on the type of Epidermolysis Bullosa. The symptoms may include:
Blistering of the skin, how severe depends on the type of Epidermolysis Bullosa.
Deformity or loss of fingernails and toenails
Internal blistering, including in the throat, esophagus, upper airway, stomach, intestines and urinary tract
Skin thickening on palms and soles of the feet (hyperkeratosis)
Scalp blistering, scarring and hair loss (scarring alopecia)
Thin appearing skin (atrophic scarring)
Tinny white skin bumps or pimples (milia)
Dental abnormalities, such as tooth decay from poorly formed tooth enamel
Excessive sweating
Difficulty swallowing (dysphasia)
Alopecia (hair loss)
Respiratory
Skin cancer is a disease that can affect any one. Skin cancer includes many types that can be classified as severe or superficial. Consequently, treatement of skin cancer depends on the degree of severity a person has. In the following paper, we will shed lights on the types of skin cancer and its causes. Finally, we will investigate how to treat the different types of cancer and how to avoid it.
Areas of red skin that doesn’t go away when pressure applied, sore skin, dry skin, hot or cold areas of skin, blisters or broken skin should all be reported. Discoloured skin should also be reported.
Epidermolysis Bullosa is a genetic disorder that causes the skin to blister even with the slightest force. Epidermolysis Bullosa is found in three different types. Each are caused by different genetic mutations. The most common form of Epidermolysis Bullosa (EB) is Epidermolysis Bullosa simplex (EBS). The less common types of EB
BB’s skin presents as pink, warm and dry. No obvious signs or symptoms of abnormal bruising or lesions present however, the patient states that the skin has of late has
Skin (history of skin disease, pigment or color change, change in mole, excessive dryness or moisture, pruritus, excessive bruising, rash
It was important to discuss with Lisa during consultation family history that could provide additional support for my final diagnostic conclusion .Going thru such topic area Lisa explain that her husband James dad was suffering with atopic eczema since childhood .This was quite an important piece of information as such conditions like atopic eczema ( dermatitis ) are hereditary conditions often (National Eczema Society ,2011).Atopic dermatitis or eczema is a chronic skin disorder inflammatory with pruritic skin that appears mostly on the face ,neck ,bends of the arms or legs caused by the malfunction in the skin barrier( NICE,2013).
Short description: People with dup15q share many symptoms, although the intensity of these symptoms varies from person to person. This page will explain the most common symptoms of dup15q and the challenges that come with them.
The highly regulated process of epidermal keratinization is the result of differential expression of within the epidermis. Basal keratinocytes express intermediate filament keratins 5 and 14. Suprabasal keratinocytes express keratins 1 and 10, which comprises approximately 85% of total proteins found in fully differentiated keratinocytes. Types I & II intermediate filaments (keratins) (Figure 3) are composed of three domains: (1) a central alpha-helical rod domain, (2) an amino-terminal head, and (3) a carboxyl-terminal tail domain both the head and tail globular domains contain end, variable, and homologous subdomains. The central α-helical domain is approximately 330 amino acids long and is divided into four subdomains (1A, 1B, 2A, and
The rash can appear in more than one place on the body at the same time.
also. The only way to keep irritants from triggering eczema is to avoid them by
Also, the area of the skin on which the symptoms appear tends to be different with every type of dermatitis.
“Psoriasis is a long-term (chronic) skin problem that causes skin cells to grow too quickly, resulting in thick, white silvery, or red patches of skin.” (WebMD, 2012) To uneducated individuals, they may look at a person with Psoriasis and think to stay away from them as it might be contagious. This disorder is not contagious, but it does affect a person with Psoriasis to go through social exclusion and discrimination. A mistaken trigger in the immune system is said to be the one of the causes of rapid production of skin cells in the body. Patients with Psoriasis produce new skin cells between 2-6 days. That is a little over four times less than the time they are normally produced, which is 21-28days. “Psoriasis affects approximately 3% of
I chose my topic because I have a skin condition, and I thought it might be a good idea to research different skin disorders. I have eczema on my foot and it was a very irritable skin disorder to go through. But thanks to the miracle of modern day medicine, all I'm left with is a scar and it is barely noticeable. Since that's my skin disorder I will begin with eczema and work my way down to pressure sores.
1. Light-colored skin and a history of sun exposure is the main cause of this type of cancer. Men are affected more often than women.
Eczema is a term that does not specify what kind of inflammation is being addressed. It is often used synonymously with dermatitis (inflammation of the skin). The different kinds of eczema depend on what body part is being afflicted. Eczema on hands, of course, affects the hands and is called cheiropompholyx.