Epigenetic Synthesis Essay

Epigenetics is defined as the science that studies communicable and reversible changes in gene expression not involving changes in the genetic support that is DNA. These changes can occur at the DNA level (cytosine methylation) or DNA binding proteins

The most compelling piece of information that I read from the article "Epigenetics: Its What Turns You On...and Off" (Schardt, 2013) is how children born from the same mother, before gastric bypass surgery and after the surgery, had different patterns of epigenetic marks than their siblings. It would not have crossed my mind that being overweight would actually have an affect on your genes, that could be passed down to your offspring. Researchers have also reported that the gene IGF2 was more turned on in those born to obese fathers, which might increase the risk of becoming overweight in adulthood (Schardt, 2013). So they chances that a child becomes overweight is on both parents and not just one.

Cancer is a disease caused by an uncontrolled division of abnormal cells. The DNA sequence in cells can be changed as a result of copying errors during replication. If these changes whatever their cause are left uncorrected, both growing and non-growing somatic cells might gain many mutations that they could no longer function. The relevance of DNA damage and repair to the generation of cancer was obvious when it was recognized that everything that causes cancer also cause a change in the DNA sequence. Tumor suppressor genes are protective genes and normally they limit cell growth by monitoring the speed of cell division, repair mismatched DNA and control when a cell dies. When a tumor suppressor gene is mutated cells grow

According to Rachael Rettner, Epigenetics is defined as, “external modifications to DNA that turn genes on or off. These modifications to DNA do not change the DNA sequence, but instead, they affect how cells read genes.” (Rettner 2013) Epigenetics is thought to possibly have a role in the development of some cancers. Since epigenetics modifies DNA, they can hide a growth, so to speak, or it can play a role in repairing the DNA’s damage. (Rettner 2013) If the changes are in the person’s sperm or egg cells, there is a possibility of that person’s children, or they’re children’s children, getting the modified DNA. (Rettner 2013) In a process called reprogramming, when the sperm and egg combine it allows the fetus to make its own epigenetic changes,

Thesis: Individuals that have experienced traumatic events or are put into high stress environments are prone to having their epigenetics modified which can be passed down to offspring. The altered genes can induce people to becoming much more vulnerable to depression and anxiety as a result. While there isn't a way to “cure” intergenerational trauma there are ways to cope with it.

Researchers first thought the genes you receive from your parents are set in stone since they are made of a genetic code set in our DNA sequence;however, they are discovering that there is a second layer of structure that combines with DNA to decide whether or not a gene is active or not, called the epigenome. The epigenome consists of the DNA, histones, a protein DNA is wrapped around, and chemical tags. The epigenome alters the genetic code by directing signals. The signals come from the environment, which are reacted upon by epigenetic tags to turn a gene either on or off without affecting the DNA sequence. Certain things from our environment that send signals to epigenetic tags to change our genes in the epigenome includes the following:

Epigenetics can be defined as a way of turning on and off certain genes in your body, which as evidence has shown, we have a lot more control of than we thought. The video on epigenetics was so great, I did not have a clear idea of what epigenetics was. Watching the video really enlightens how far we have come in research of the human body. I find the advancements that have been made using epigenetics with cancer to be one of the best sections of the thirteen minute video. Just knowing the fact that half of the patients that complied with the research whom had cancer to begin with are now in remission is a great accomplishment. I also found the fact that we have more control over our epigenes, we are to modify our own genes by just following

As of late there has been more of a focus on the Epigenetics component of mental illness.

The PBS video called “Epigenetics” brought to light some very interesting views. Through rats scientist have been able to see the works of epigenetics and believe that the finding have led to the idea that the change in genetics has the same effect on humans. The most interesting part of the video was that younger pairs of twins have very similar genes, but the older pairs of twin have more epigenetic difference in their genes. This validates the idea that the epigenetic difference in old twins is caused by environmental factors such as lifestyle choices. The idea also alludes to the idea that our parents and grandparents healthy and epigenetics may affect my heath and my children’s health. This leads to the inclination that my child’s health

What is epigenetics? Epigenetics to me is the alteration to our genome that we are able to change in not only ourselves but in our children and future generations as well all based on lifestyle habits we live today. After first watching the PBS video on epigenetics, I was astonished on how our ways of life have such a profound effect upon not only our genes but our future generations of children as well. In the video research was conducted on over forty identical twins ages ranging from three to seventy-four, this was to compare the lifestyle habits such as smoking, exercise, and different diets have on an individual. I found it fascinating that when there was comparing the genomes of the elderly Spanish twins compared to the three-year-olds; we were able to see how much of a difference the Spanish twins genome

For years, scientists believed DNA, deoxyribonucleic acid, was the end-all-be-all: a mould for our cells to be created from. Which does not sound far-fetched since DNA contains all of the information needed for replication, differentiation, growth, and development, in addition to the countless cellular fates, as described in Waddington’s landscape. Instead, DNA is a guide for our cells, and Epigenetics is the tool that coerces them into their final cellular form. The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance written by Nessa Carey, outlines the process of DNA versus Epigenetics, and the developments they have had within the scientific field. This paper will examine the fundamental distinction constructed by Nessa Carey between DNA as a script versus a template. This analogy of DNA as a script.

DNA is tightly coiled around core histone proteins in chromatin, forming nucleosomes. Linker histones bind nucleosomes together as chromatin. Acetylation, Methylation, phosphorylation, or ubiquitination of the N-terminal tails of each of the core histones affect the binding of the histone proteins to DNA. These modifications change the structure of the chromatin and allowing transcription factors accessibility to DNA regions. The combined effect of these modifications creates a histone code, which regulates gene expression. Of these various modifications, histone acetylation is the extensively studied, because of its role in the development and progression of tumors. Histone acetylation is controlled by histone acetyltransferases (HATs) and

Many studies have explored the impact of nature and nurture on stuttering behavior, but for our project we wanted to focus on epigenetics as well as specific genes hypothesized to be related to stuttering. Epigenetics is sometimes referred to as the bridge connecting nature and nurture. Epigenetics is the study of heritable changes in gene expression that do not involve changes to the underlying DNA sequence. In other words, a change in phenotype without a change in genotype. Epigenetics is suggested to reside in methyl groups, histones, and noncoding RNA. DNA methylation can be compared to turning on a faucet, in which this process turns genes “on” and “off.” Meanwhile, histones control “how much water is flowing through the faucet, by determining how tightly or loosely the DNA is wound and “read.” Finally, non-coding RNA are functional RNA molecules that are transcribed from DNA but not translated into proteins.

Epigenetics tell your genes what to do. They are basically a switch turning a gene on or off. The research currently being done shows that the persons’ environment can directly affect their genes. Research being done by Michael Skinner shows that exposure to a known teratogen, pesticides, are having a direct impact on our genes. The pesticides are causing some epigenetics to turn on and others to shut off. This one example of how some teratogens are epigenetic influences. Yes, we need to be wary of where, when, how, and if we decide to use most household chemicals. There have been many studies showing that chemicals can affect our health. Further research needs to be done into epigenetics and teratogens in general and into household

One of the hallmark alterations during the carcinogenic process is a profound deregulation the intracellular metabolism and exposure to carcinogenic agents greatly contributes to this deregulation. The proper functioning of many chromatin-modifying enzymes, in particular, and epigenetic processes, in general, depends greatly on cofactors or cosubstrates generated by cellular metabolism. This tightly links a number of intracellular metabolic and epigenome and, therefore, altered intracellular metabolism, especially tricarboxylic acid cycle (TCA cycle; Krebs cycle), one carbon, lipid, and iron metabolic pathways, induced by carcinogen exposure can cause a variety of epigenetic abnormalities