Epigenetics And Autistic Spectrum Disorder

1078 Words Nov 30th, 2014 5 Pages
Epigenetics and Autistic Spectrum Disorder

Jowan Jones
Old Dominion University Abstract This paper plans to focus on autism spectrum disorder and how epigenetics contributes to the development of the disease. ASD is comorbid with other neurodevelopmental diseases including Rett Syndrome, Fragile X, Prader-Willi, and Angelman. These diseases have frequent, identifiable symptoms such as coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and or development, genital and or urinary abnormalities, and ear abnormalities and deafness. The definition of stochastic is to have a random probability distribution or pattern that may be analyzed statistically but may not be predicted precisely. Epigenetic marks are modifiable both in the germline and in somatic tissues by genetic, environmental and stochastic factors. “Epigenetic dysregulation is highly implicated as a contributing cause of ASDs and Autism.” (Bess M. Flashner, 2013) Weakened methylation and alterations of MeCP2 have been linked with autistic spectrum disorders, and related Rhett syndrome. (Currenti, 2010) The discussion here states how ASDs, Rhett Syndrome and other neurodevelopmental diseases are related and how the mutation of certain chemicals can acerbate those conditions.

What Is Epigenetics?
As a person grows and develops, chemical reactions activate and deactivate parts of the genome. Epigenetics is the study of those chemical reactions and the factors that…
Open Document