Errythroderma Research Paper

The patient was referred for a new itchy and tender bilateral groin lesions that the patient says will drain pus. He also has multiple other complaints. He gives a history of being allergic to DOXYCYCLINE. As previously stated, he has tender sites which can drain pus off and on in his groin for years. There is also history of facial acne and scalp acne since his late teens. He took Accutane during his 20s with improvement by history. He flared and repeated Accutane about one year after completing the first course by his history. He is bathing with unscented Dove and uses cocoa butter lotion. He also has a second problem of itching over his back, shoulders, and arms, and legs

The general health of the patient is currently being compromised due to present illness mentioned above, but is stable. L.H. reports his usual health to be, “normal and not too crazy like this”. Patient has some fatigue noted while conducting daily activities; No recent weight change, fever or sweat. The skin noted to some discoloration on upper right side of back. There is no pruritus, rash or lesions present. Bruises noted bilateral on arms. Patient reported taking baby aspirin as daily medication. His hair is greying and thinning with no hair loss.

Laboratory: CK 41, aldose 5.7, CCP 5, rheumatoid factor 10.8, ANA negative, ANCA is less than 1:20, P-ANCA less than 1:20, hypersensitivity pneumonitis panel is negative, anti-Jo-1 is less than 0.2, scleroderma antibody is less than 0.2, IDE total 5. CBC within normal limits.

Tracey is a 41-year-old female here today to discuss a possible yeast infection as well as a "bump" that she found in the vaginal area.

A 54 year old Caucasian Male presented with a two week history of right ankle weakness and gait imbalance. He also complained of fifty pound weight loss over six months. Patient had undergone renal transplant four years earlier due to polycystic kidney disease. Therefore, he had been taking Tacrolimus since then. Examination revealed tender nodules on the skin of his forehead, neck and arms. Examination also revealed a right foot drop.

Relapsing polychondritis is thought to be a rare auto immune disease. While reading articles and research I found that those with relapsing polychondritis had antibodies against type II collagen and in increase in HLA-DR4 antigen which gives insight to the etiology of the disease. An abundance of research is done by case studies and mouse/rat models. A patient has increased erythrocyte sedimentation rate and C reactive protein as well as leukocyctosis, thrombocytosis, chronic anemia, and high levels of alpha and gamma globulins. CD4 T cells are at the site of inflammation which indicate cartilage as the target. They also have low levels of antinuclear antibody and antineutrophil cytoplasmic antibodies. The disease’s severity can vary

The 34-year old male patient with the presenting symptoms of discolored skin patches and nodules, deformity of the nose, loss of libido, hair loss, testicular atrophy, partial loss of pinprick and temperature sensation, and enlarged nerves, has a disease called lepromatous leprosy. Lepromatous leprosy is when there are a large number of bacteria found in the skin lesions.

The patient is a 41-year-old female comes in because for the past four days, she has had a rash on her elbows bilaterally. It is quite itchy. It made it difficult to sleep last night. She states she has never had a rash like this before, she has no history of eczema. She has been working in a new situation and perhaps got exposed to new work environment. She does spend time at her computer with her elbows on the table. She otherwise is feeling well, no fevers, no other rashes.

My interest with the topic impetigo is at the highest peak because one day I see myself working with children as a Certified Medical Assistant. My goal is to find the most common diseases in children, and impetigo is one of them.

According to Merck Manual Professional Edition (n.d), contact dermatitis is a condition of skin becoming red and sore after contacting with allergens substances. The clinical manifestations that the 27 years old is showing contact dermatitis. Contact dermatitis is cell mediated hypersensitivity allergic reaction by Langerhans (dendrites epidermal cells), which then the cells migrate to reginal lymph nodes where they present the antigen to T cells. T cells then release cytokines and activate inflammatory cells. (Huether & McCance,

Many SSc patients have increased activated T cells and soluble interleukin-2 (IL-2) receptor [8, 9]. Some SSc patients also have CD25+ CD4+ T cells that are type I collagen (COL1) specific, an ECM protein that is often overexpressed in SSc [10]. Many SSc patients present with autoantibodies. Though the importance of autoantibodies in disease progression is debated, they are useful in predicting subset and disease progression [11]. Common SSc–related autoantibodies include, anti-centromere antibodies (ACA), anti-Scl-70, anti-topoisomerase (TOPO), and anti-nucleolar antibodies including anti-U1-RNP, anti-fibrillarin, anti-RNA polymerase I, II, III, anti-U3-RNP, anti-Th/To, and anti-Pm/Scl. The types of autoantibodies produced are often dependent on SSc subset and ethnicity

The scientist found that out of all of the patients gathered, only 98 individuals had dermatitis herpetiformis. In searching for autoimmune disease and lymphoma, all patients were included assessing the patients with DH compared to those without. The diagnosis of DH and presence of autoimmune disease was proved in all

This patient is mostly likely suffering from Post-transplant lymphoproliferative disorder, commonly called PTLD. Besides skin cancer, PTLD is one of the most common malignancies of post transplantation (LaCasce, 2006). Approximately 15% of transplant patients develop PTLD and it has a higher incidence amongst children than adults (DynaMed Plus, 2017) PTLD has a variety of presentations which lends to the difficulty and diversity of treatment options used for the disorder. The sites affected by PTLD and the incidence of the disorder depend its association with Epstein Barr virus and the transplant organ (LaCasce, 2006). The associated EBV infection is most commonly due to the donor graft and less commonly due to new environmental exposure

Fixed drug eruption (FDE) is a unique type of cutaneous adverse drug reaction. They were first described by Bourns1 in 1889 and later by Brocq2 as “eruption erythemato-pigmentee fixe”. It is characterised by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques that may blister and is often associated with pruritus. The lesions generally leave behind some amount of residual hyperpigmentation. These lesions typically appear within 30 minutes to 24 hours of administration of the incriminated drug.1 The usual sites of involvement are hands, feet, genitalia and perianal region whereas it is seen less commonly around the mouth and trunk. There is a characteristic recurrence at the same sites on repeat administration

[Adapted from Pan M, Liu X, Zheng J. The pathogenic role of autoantibodies in pemphigus vulgaris. Clin Ex. Dermatol 2011;36(7):703-07.]