Escherichia Coli : An Important Food Borne Zoonotic Pathogen

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Escherichia coli, is the most prevalent pathogen which is commonly known for its affiliation with human and animal infections and diseases such as diarrhoea, in addition to several clinical symptoms including haemorrhagic colitis, haemolytic uremic syndrome (HUS), and thrombocytopenic purpura (Liu et al., 2012; Vanaja et al., 2010; Tomat et al., 2013). HUS in humans, is caused by a predominant type of enterohaemorrhagic E. coli (EHEC) in the United States. It is also the chief cause of acute renal failure in children. There has also been documentation of strings of outbreaks since its identification as a pathogen in 1982, happening basically in Canada, Japan, United Kingdom and United States, implicating domestic animals such as sheep,…show more content…
This has been a more pragmatic approach to the control of these pathogens because of the development of antibiotic resistance. This therapy has been used profitably since the early 1920s and encouraging results have been generated by the use of phage-mediated biocontrol of pathogenic E. coli in animals such as pigs and cows. A study was done on calves and piglets who had diarrhoea due to experimentally administered pathogenic E. coli. Results showed they were cured within 8 hours after phage administration. More studies also revealed that phage could act very successfully as a prophylactic. Recent results of phage therapy against other bacterial pathogens have also shown great potential. For example, it has been shown that intraperitoneal injections of bacteria (Staphylococcus aureus) finally cause death in mice while the application of intraperitoneal injection of phage after that of the bacteria very much reduces the fatality of the bacteria (O’Flynn et al., 2004; Biswas et al., 2002; Clark and March, 2006). Regardless of the pathogenic E. coli, some species are non-pathogenic strains which are normal and ecological essential inhabitants of the human and animal gastrointestinal tracts. Non-pathogenic and pathogenic E. coli differ with respect to the presence of genetic information that may
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