Essay On A Placebo Controlled Trial Of Antibiotics

Methicillin-resistant Staphylococcus aureus, or more commonly, MRSA, is an emerging infectious disease affecting many people worldwide. MRSA, in particular, is a very interesting disease because although many people can be carriers of it, it generally only affects those with a depressed immune system; this is why it is so prevalent in places like nursing homes and hospitals. It can be spread though surgeries, artificial joints, tubing, and skin-to-skin contact. Although there is not one specific treatment of this disease, there are ways to test what antibiotics work best and sometimes antibiotics aren’t even necessary.

Describe methicillin resistant Staphylococcus aureus (MRSA) and its implications for patients who are diagnosed with this.

Cultures are an effective way of guiding the Infectious Disease specialist to which antibiotics that are to be used to treat the patient with MRSA by looking at the type of strain that the patient has. The culture can also be tested for susceptibility to a variety of antibiotics. Surgery may be required to debride and drain the pus filled skin from the infected area, while antibiotics, such as vancomycin, linezolid, daptomycin, quinupristin/dalfopristin, clindomycin (as well as many other sulfa drugs and tetracyclines) could be prescribed to help eradicate the infection. Some antibiotics that are used to treat MRSA are only available intravenously. Unfortunately, some high-powered antibiotics are developing resistance to MRSA infections. Because of this, Vancomycin is no longer a sure treatment for MRSA due to questions surrounding its effectiveness. Patients that are prescribed antibiotics should never stop taking their antibiotics, even if they are starting to feel better. These infections are extremely dormant and are prone to reoccur if they develop resistance to the

Skin and or soft tissue infections often occur following a break in normal skin integrity from either trauma or skin disease (Brown & Ebright, 2002). The vast majority of these infections are caused by the gram-positive bacteria Staphylococcus aureus, part of the normal flora existing on the skins surface. Abscess has been found to be the most commonly found SSTI in PWID (Brown & Ebright, 2002). Symptoms of abscess include pain and or tenderness at and around the site of infection, swelling, and redness topped with a pustule. If left untreated, spread and progression of the SSTI leading to tissue ischemia and death, gangrene, sepsis and death can occur (Brown & Pieper, 2002). Hospital treatment of a SSTI is costly. Analysis of the Nationwide Inpatient Sample by the Agency for Healthcare research estimated that in 2009, costs associated with hospital treatment of SSTI reached an estimated $4.8 billion, which is approximately $11,000 per patient (Suya et al., 2009).

MRSA (Methicillin Resistant Staphylococcus Aureus) is one of the most recent superbugs to become a health problem. MRSA is a species of Staphylococcus Aureus that is resistant to the antibiotic methicillin and antibiotics like it. Doctors are struggling to find proper treatment because of its resistance to the beta-lactam ring, the core of most antibiotics. The most lethal strain is the CC398 strain, most commonly found on livestock. There are approximately 80,000 invasive MRSA infections and 11,000 deaths every year. (CNN.com)

MRSA stands for Methicillin-resistant Staphylococcus aureus (MRSA) and is a bacterial infection that is highly resistant to some antibiotics. In short, antibiotics have been used since the 40's to stop the growth of bacteria. However, the more antibiotics are used, the quicker the bacteria become resistant to it while each year more types of bacteria adapt and become resistant to antibiotics. With MRSA being so resistant to many of the antibiotics, classifying it as a “super-bug”, it makes treatment of skin infections and invasive internal infections much more complicated. This leads to many yearly deaths. In fact, MRSA statistics show that more people die each year from MRSA infections than the

Both health care-associated and community-associated strains of MRSA still respond to certain antibiotics. In some cases, antibiotics may not be necessary. For example, doctors may drain a superficial abscess caused by MRSA rather than treat the infection with drugs. In the hospital, people who are infected or colonized with MRSA often are placed in contact precautions as a measure to prevent the spread of MRSA. Visitors and health care workers caring for people in isolation may be required to wear protective garments and must follow strict hand hygiene procedures. Contaminated surfaces and laundry items should be properly disinfected. Preventing MRSA includes careful hand washing remains your best defense against germs. Carry a small bottle of hand sanitizer containing at least 62 percent alcohol for times when you don't have access to soap and water. Keep cuts and abrasions clean and covered with sterile, dry bandages until they heal. The pus from infected sores may contain MRSA, and keeping wounds covered will help prevent the bacteria from spreading. Avoid sharing personal items such as towels, sheets, razors, clothing and athletic

The problem with control methods is that once using them for a long period of time they become resistant and no longer work effectively resulting and finding new methods and will also result in them becoming resistant. (Cooper, et al 2004) has found that hospitals have stayed with three control methods guidelines that include restrictions of antibiotics, washing your hands and having a proper hygiene and the ability to detect and isolate patients who are infected with MRSA . The best method that hospitals are taking into consideration is isolating infected colonized patients, because it is known that patient to patient transmit infections do occur more than any other way. Data research has been found that the safest way to prevent further contamination of the spread of methicillin-resistant staphylococcus is to follow these three proper safety guidelines (Chaberny, et al

According to the Centers for Disease Control and Prevention [CDC] (2016) "MRSA can cause severe problems such as bloodstream infections, pneumonia and surgical site infections. If not treated quickly, MRSA infections can cause sepsis and death” (para. 1). Elderly and individuals with depleted immunity (Mayo Clinic, 2016), patients in intensive care units (ICUs) where the antibiotic resistance and antibiotic use are the highest (Ma et al., 2015, p. 1), nursing home (NH) residents, and patients with indwelling devices are the most vulnerable population for the MRSA infection (Mayo Clinic, 2016). MRSA infections can put financial and physical strains to the healthcare system as observed by Hanna (2011), “MRSA costs the US healthcare system up to $34 billion a year and accounts for over 8 million additional hospital

“Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of preventable nosocomial infections and is endemic in hospitals worldwide” (Sadsad, Sintchenko, McDonnell, Gilbert, p.1, 2013). MRSA is a bacterial infection that is resistant to antibiotics that are usually used to treat staphylococcus infections. MRSA is mostly found on the skin, but can also be seen in wound or sputum. Nurses and other healthcare workers can help prevent the spread of MRSA by maintaining a good hand washing hygiene, putting patients in isolated rooms. However, patients with a history of MRSA should have an indicator on the door to inform staff of the infection. Nurses and other staff that will have physical contact with patients should be meticulous about using standard precautions, such as wearing protective equipment like gowns and gloves when handling patients with

Before the turn of the 21st century, physicians across the country were realizing that the possibility of being able to treat and cure virtually any microbial infection with the use of a single or a combination of antimicrobial medications was becoming more and more of a challenge. In the late 1960s and early 1970s, reports of pathogenic resistance to even the most potent antimicrobial medications of the time were being sent to the Centers for Disease Control. Among even the most dangerous pathogens that have developed and are developing drug resistance to one or many antimicrobials, Staphylococcus aureus (S. aureus) is perhaps a case in which the world is most familiar and of the greatest concern within the medical community due to its natural virulence-its ability to cause a multitude of life-threatening infections, and its above average ability to combat and adapt to a vast array of environmental conditions.

MRSA is a strain of Staphylococcus aureus that stands for Methicillin Resistant Staphylococcus (Staph) Aureus. Staphylococcus aureus is a gram-positive coccal bacterium that is commonly found in the nose and on the surface of the epidermis of healthy patients, which act as a part of the normal flora, whereas, MRSA can commonly be found on the surface of the skin near the mouth, genitalia and the rectum. (MRSA symptoms, n.d.). MRSA is a specific strain of staph that over time has mutated to become resistant to most antibiotics. MRSA is referred to as being methicillin resistant because that antibiotic, methicillin is the primary antibiotic that is used to treat most strains of Staph aureus and unfortunately this particular strain of Staph, MRSA, is unaffected by its typical antibiotic treatment. MRSA is most commonly acquired nosocomial infection, or more commonly known as a hospital acquired infection. Though it is not as likely, there is a slight possibility of becoming infected with MRSA

Staphylococcus aureus is a gram-positive coccal bacterium that is a member of the Firmicutes, and is frequently found in the nose, respiratory tract, and on the skin. It is often positive for catalase and nitrate reduction. Although S. aureus is not always pathogenic, it is a common cause of skin infections such as abscesses, respiratory infections such as sinusitis, and food poisoning. Pathogenic strains often promote infections by producing potent protein toxins, and expressing cell-surface proteins that bind and inactivate antibodies. The emergence of antibiotic-resistant strains of S. aureus such as Methicillin-resistant S. aureus (MRSA) is a worldwide problem in clinical medicine.

Staphylococcus aureus (S. aureus) is a common skin infection contracted in the community and healthcare systems. Methicillin- resistant Staphylococcus aureus (MRSA) was originally resistant to the antibiotic methicillin which is a form of penicillin. MRSA is now resistant to many other antibiotics such as; penicillin, vancomycin, and erythromycin (Sakoulas. G., Moellering. R.C.Jr., 2008). What this means is that the antibiotics have lost their ability to control or kill the bacteria. MRSA was first seen in healthcare in the 1940’s (Herwaldt. L. A., 1999). Since it is commonly contracted and can live in many environments, we now see MRSA in the community. MRSA can only be contracted by physical touch with an infected individual. If

In our study, the blood samples (32 isolated from 134 available isolates) were the highest among other samples. 11.9% of all specimens belonged to the MRSA strains taken from blood samples, which are similar to the findings of the study by Mostafa et al. In 2015 in Tehran, the highest number of isolates S.aureus bacteria wasisolated from blood samples (27 out of 139 isolates obtained) (4). In this regard, and in a study conducted by Ren et al. in China in 2009, from 186 isolates of Staphylococcus aureus, 67.9% were MRSA strains from sputum (10). The difference in the presence of MRSA between our studies and Ren et al.’s study could be due to the differences in the control of the transmission pathways of this bacterium in any of the sampling hospital.