Essay On Acute Myeloid Leukemia

Phase 3 clinical studies - Intended to gather the additional information about effectiveness and safety that is needed to evaluate the overall benefit-risk relationship of the drug.

One of these symptoms is jaundice, which is characterized by yellowish skin and eyes because of an inability of the liver to remove bilirubin from the blood. Patient with cirrhosis also suffering from itching, due to deposited bile's products in the skin. This patient also suffers from accumulation of fluid in legs that is called edema. As a result of the blockage of blood flow via the liver, fluid accumulation in abdomen which is worsen by the decrease in protein production. Other symptoms include fatigue, weakness, loss of appetite, weight loss and nausea. As the disease progress, complications may develop ,such as varices that happens with cirrhosis patient when the blood flow through the liver slows, so the blood from intestine go back to the vessels of the stomach and esophagus, these vessels are not meant to carry this much of blood so they dilate (varices), with increasing

The CDC estimates that each year, more than eight million people are diagnosed, and consequently died from cancer, and this statistic was even higher in the 1950s. During this period, little was known of cancer’s effects on the

leading cause of cancer related mortality within the community for both men and women was

Americans must wait up to 19 years after a discovered treatment before they can participate in benefits of a new medication (Philipson & Sun, 2008). The regulatory process drug manufacturers need to endure before releasing potentially life-saving medication is an extremely expensive, time-consuming process. The Center for Drug Evaluation and Research (CDER) is the main department of the Food and Drug Administration (FDA) responsible for the safety of drugs (both prescription and over-the-counter) sold in the United States (Food and Drug Administration, 2011). This department scrutinizes the testing of new drugs and

Acute Lymphoblastic Leukemia, is the disease that affects children the most and because of the abnormal cells that are immature white blood cells which cannot help the body fight infections cause children with the disease to often get infections and have fevers (National Cancer Institute, 2002, p. 1). The symptoms that the patient with ALL may have depend on the number of abnormal cells of the patient where exactly the cells collect. Children patients with ALL have low amounts of healthy red blood cells and platelets, which cause less oxygen to be carried through the body because of the lack of red blood cells. Patients at times may look pale, feel weak, and tired causing bleeding and bruising very easily because of their lack of enough platelets. This condition is called anemia. Anemia is very much common in patients with acute lymphoblastic leukemia. Fever, fatigue, bone or joint pain, tiny red spots under the skin called petechiae are a couple of symptoms that the disease ALL has. Headaches with, or without vomiting also may occur if patient happens to have abnormal cells collecting in the brain or spinal cord (National Cancer Institute, 2002 para. 2).

The most common cancers that have ended in death are, lung, bowel, prostate (males), breast (females) and pancreatic cancers. These cancers are the most common within the older population due to the time when they were young, their wasn’t any or many knowledge about cancer and how to prevent cancers. For example, 50% of lifetime exposure happens in early life and the skin cancer

Cancer is the main cause of death in the world, estimating 8.2 million fatalities in 2012 alone

“The Emperor of All Maladies” captured the whole essence of cancer. This book gave a very good narrative of the historical record of cancer, the scientists and important public figures who contributed to the fight against a disease that has so much caused despair, pain, disfiguring of the body and worst of all, death. Cancer is seen as the abnormal growth of cells. A normal cell becomes cancerous when there is a defect in the regulation of its growth. Cancerous cells also tend to be elusive and resistant to treatments. Numerous attempts have been channeled into demystifying the nature of cancer. Some of these attempts proved abortive while a few served as a harbinger of hope. Cancer have proved to be part of our genetic makeup, hence, total eradication of it remains a future accomplishment.

Cytogenic analysis – Microscopic examination of lymphocytes to look for structural changes or changes in number of chromosomes.

Leukemia is a type of cancer. Cancer is a group of more than 100 diseases that have two or more important things in common. One is that certain cells in the body become abnormal. Another is that the body keeps producing large numbers of these abnormal cells. Leukemia is cancer of the blood ce3lls. When leukemia develops the body produces large numbers of abnormal blood cells. In most types of leukemia, the abnormal blood cells and they do not

Picture yourself at a check-up appointment with your oncologist. You are told the chemotherapy is not responding. You feel weaker each day. You cannot see straight, you feel dizzy, and you pray that you will find a match for a bone marrow transplant. This is the reality that AML patients face. AML poses the greatest risk to cancer survivors who develop this disease following treatment for a previous cancer—for these patients, it is the next hurdle in their lives (Cancer Research UK). When chemotherapy does not work and bone marrow transplant matches cannot be found, patients realize that they do not have much time left in this world. New treatments are desperately needed for AML, but many just assume that donating money to the American

There are two types of leukemia in children; acute and chronic. Acute is fast growing leukemia. Within acute leukemia are three categories: acute lymphocytic (lymphoblastic) leukemia (ALL), acute myelogenous leukemia (AML), and hybrid or mixed lineage leukemia. Acute lymphocytic (lymphoblastic) leukemia (ALL) is the most common type of childhood leukemia and develop from early forms of lymphocytes, also known as white blood cells. Specifically, three out of four childhood leukemias are ALL (About Childhood Leukemia). Acute myelogenous leukemia (AML) starts from the myeloid cells that create blood forming cells such as white blood cells (except for lymphocytes), red blood cells, and platelets (About Childhood Leukemia). Hybrid or mixed lineage leukemia are rare forms of childhood leukemia, but can be treated like ALL and AML. On the other end of the spectrum is chronic, or slow growing, leukemia. Chronic leukemia is difficult to treat and are more commonly found in adults than children. There are two types of chronic leukemia: chronic myelogenous leukemia (CML) and chronic lymphocytic leukemia (CLL). Chronic myelogenous leukemia (CML) is not commonly

Cancer is one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases in 2012.2 The amount of new cases is expected to rise by about 70% over the next 2 decades. Cancer which causes nearly 1 in 6 deaths, is the second leading cause of death globally, and was responsible for 8.8 million deaths in 2015. Approximately 70% of deaths from cancer occur in low- and middle-income countries. In 2012 about 14.1 million new cases of cancer occurred globally (not including skin cancer other than melanoma).3 The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer.

One factor that must be considered is that the drug had not yet been approved by the FDA, but was in phase III trials. Historical data shows that 65% of drugs in this phase eventually get approved for sale to the market. It was felt that approval of the drug would occur late in 1998.