Essay On Endogenous Modulation Of Pain

p.483 The cell bodies of primary-order neurons or pain-transmitting neurons reside in the dorsal root ganglia just lateral to the spine along the sensory pathways that penetrate the posterior part of the cord. The second order neurons are found in the dorsal horn (p.484) Most nociceptive information tranvels by means of ascending columns in the lateral spinothalamic tract (also called the anterolateral funiculus). The principal target for nociceptive afferents is the thalamus (the major relay station of sensory information in general) Third order neurons project to portions of the CNS involved in the processing and interpretation of pain, the chief areas being the reticular and limbic systems and cerebral cortex. (p 484)

Pain is not only defined as a sensation or a physical awareness, but also entails perception. Moreover, pain is an unpleasant and an uncomfortable emotion that is transferred to the brain by sensory neurons. There are various kinds of pain and how one perceives them is varied as well. Certain parts of the brain also play a key role in how one feels pain such as the parietal lobe, which is involved in interpreting pain while the hypothalamus is responsible for the response to pain one has. Although some believe pain is just a physical awareness and is in the body, pain is all in one’s mind because the perception of pain and the emotion that controls its intensity differs in individuals and when pain itself is administered to the body, the brain determines the emotions one attaches to each painful experience.

Gertler clarifies that pain refers to the sensation and not the common cause, which is C-fibers firing in a specific area with tissue damage. (109) She asserts that pain is not essentially connected to tissue damage of a particular location, indicating to me inadequate understanding of the concept. If one pinches one's arm, though the sensation of pain may not be necessarily located in the arm, I contend that the pain felt is relevantly connected to the location pinched. Gertler provides the alleviating effect of painkillers as an example of a non-essential feature of pain. (117) Location is unlike this property, however, and is essential in conceptualizing pain. For instance, even an amputee, who had a leg removed and experiences a phantom leg-pain, is unable to describe the sensation they feel without making reference to a specific body part. Whether or not the pain is actually “located” anywhere is irrelevant, it matters only that the pain is conceptualized as having a location. Our understanding of pain relies fundamentally on where the pain is thought to be “located.” The fact that it is impossible to conceive of pain without reference to the “location” of the sensation proves that location is an essential feature of

Chronic pain has four mechanisms. Nociception is a neural signal of threatened or damaged tissue, and is the classical pain pathway. Central pain states are thought to be caused by abnormal activity in neurons in the afferent pathway. The mechanism for this is not completely understood, and a person may perceive pain where there is no tissue damage. Behavioral pain is communicated by a

Pain is not just a symptom, but a specific problem that needs to be treated. Pain is a neurologic response to unpleasant stimuli. What is the gate control theory of pain? What are the classifications of pain? What are some ways to manage pain?

To most people, pain is a nuisance, but to others pain controls their life. The feeling discomforts us in ways that can sometimes seem almost imaginable. These feelings can lead to many different side effects if not dealt with or diagnosed. These effects can include depression, anxiety, and incredible amount of stress. The truth about pain is that it is vital to our existence. Without the nervous system responding to pain, we would have no idea if we were touching a hot stove, being stuck by a porcupine’s needles, or something else that could leave a lasting effect upon our bodies without us even knowing anything about it.

To most people, pain is a nuisance. But to others, pain controls their life. The feeling discomforts us in ways that can sometimes seem almost imaginable. These feelings can lead to many different side effects if not dealt with or diagnosed. These effects can include depression, anxiety, and incredible amounts of stress. The truth about pain is that it is vital to our existence. Without the nervous system responding to pain, we would have no idea if we were touching a hot stove, being stuck by a porcupine's needles, or something else that could leave a lasting effect upon our bodies without us even knowing anything about it. This warning system helps to alert us when there is

Pain perception can be less than might be expected from the extent of a physical injury. This was proven by a scientist called Susana Bantick, Oxford University, and colleagues who carried out a study on the influence of attention distracting pain processing (Bantick et al, 2002). During the experiment, brain processing was measured by measuring brain activity using fMRI. Participants rated pain from 1-10 when noxious heat stimulus was applied to their hand in the scanner. She then followed the same process but gave them a task which required cognitive processing; reducing the amount of focused attention on pain. Bantick, therefore, showed attention distraction can reduce the amount of pain perceived by the individual, also pain processing to the brain was reduced. This provides vital evidence that pain perception does not just depend on the injury alone.

The brain develops in such a way that it leaves itself vulnerable to these negative influences. The prenatal brain develops an overabundance of neurons, some of which are then carefully eliminated before age 4 (5). In a process similar to this, the amount of synapses between neurons is built up during early childhood and then pruned back for the next 30 years of life (5). These two processes are both disturbed by elevated levels of stress hormones (5). The two centers of the brain with the most postnatal changes, including the growth of new neurons after birth, are the hippocampus, which is part of the limbic system, and the cerebellar vermis (6). The hippocampus is in charge of creating and retrieving memories, working together with the other parts of the limbic system, such as the amygdala, which records the emotions for each memory. The vermis controls the production and release of two of the catecholamine neurotransmitters, dopamine and norepinephrine (6). Both the vermis and the limbic system have higher concentrations of receptors for the stress hormone cortisol than anywhere else in the brain (6). Due to this fact, these still-developing areas are the most vulnerable to the damage done by elevated levels of stress hormones.

which in turn inhibits the second order neurons that transmit the nociceptive signals to the

Feelings of pain, euphoria, and pleasure all can come from the body’s natural pain killers, endorphins. The history of endorphins dates to the 1960’s, when a researcher named Choh Hao Li accidentally discovered them in the pituitary gland. Since they didn’t pertain to his current research, he didn’t study how they work until later. Endorphins were found later at pain receptor sites (also called the opiate receptors) in the brain and linked to being released by the pituitary gland when the body is under extreme stress. (R. David Cole, 1996)

Further studies in 1998 investigating the re-mapping component in the brain were conducted by researchers at the University of Toronto and The Toronto Hospital. The study recruited amputees who experienced phantom pain for surgery to map the sensory areas in the brain. During the mapping process, the conscious patients reported sensations they felt when certain areas of the thalamus were stimulated. Patients reported phantom sensations when areas of the thalamus were stimulated that formally were innervated by neurons from the missing arm, and also when areas on the stump were stimulated that activated these reorganized regions in the brain. Neurons were shown to continue to carry out their original roles, but with different sources of activation (7).

An extensive matrix of neurons in the brain gives us the sense of our own bodies and body parts. Pain results when this matrix produces an abnormal pattern of activity, as a result of memories, emotions, expectations or signals from various brain centres and not just from signals from peripheral nerves. Because of the lack of sensory stimulation or a person’s efforts to move a nonexistent limb, abnormal patterns may arise, resulting in phantom pain.

Pain is something that connects all of us. From birth to death we can identify with each other the idea and arguably the perception of it. We all know we experience it, but what is more important is how we all perceive it. It is known that there are people out there with a ‘high’ pain tolerance and there are also ones out there with a ‘low’ pain tolerance, but what is different between them? We also know that pain is an objective response to certain stimuli, there are neurons that sense and feel pain and there are nerve impulses that send these “painful” messages to the brain. What we don’t know is where the pain

The International Association for the Study of Pain defines pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” (1979). Pain is actually the culprit behind warranting a visit to a physician office for many people (Besson, 1999). Notoriously unpleasant, pain could also pose a threat as both a psychological and economic burden (Phillips, 2006). Sometimes pain does happen without any damage of tissue or any likely diseased state. The reasons for such pain are poorly understood and the term used to describe such type of pain is “psychogenic pain”. Also, the loss of productivity and daily activity due to pain is also significant. Pain engulfs a trillion dollars of GDP for lost work time and disability payments (Melnikova, 2010). Untreated pain not only impacts a person suffering from pain but also impacts their whole family. A person’s quality of life is negatively impacted by pain and it diminishes their ability to concentrate, work, exercise, socialize, perform daily routines, and sleep. All of these negative impacts ultimately lead to much more severe behavioral effects such as depression, aggression, mood alterations, isolation, and loss of self-esteem, which pose a great threat to human society.