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Essay On In Vitro Studies

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In-vitro studies are considered as a preclinical research and of important significance, as before carrying out clinical trials, the safety and effectiveness of new drugs are examined In-vitro first. However, unlike clinical studies on humans, preclinical studies are far enough, by 2002, the lancet outlined a scientific rational for conducting SRs on animal studies, after that, manny SR and meta-analysis of in-vitro studies were published(1) Including studies discussing the modeling of cerebrovascular disease(2)
So like SR and Meta-analysis on humans, the quality assessment and risk of bias in SR and meta- analysis of in-vitro studies needs to be tested and examined. (1)
Empirical evidence reports that too many …show more content…

we will invite the 65 corresponding authors of our systematic review, some international researchers who are experts in QA, have an interest in experimental studies, and journal editors who are interested in publishing SR of in-vitro studies.
By using email survey or Survey website, we will conduct a two to four rounds of sending, receiving, modify and resend again.
The objective of the first round is that the panelists will show their opinion about the items included in the initial checklist, rank the importance of each criterion included and suggest new items if needed.
In the second round, we will receive their feedback on the results of the first round, re-rank the importance of the criteria which did not reach a 70% consensus of inclusion or exclusion, and indicate the importance of the proposed criteria during the first round.
The third round, to further refine the checklist, whether excluding any less important criterion or re-including any of the excluded criteria in the checklist.
The fourth round, to review the final checklist and recommend for further improvement(4).And third, a pilot test of the new tool, using a random sample as a pilot from the included studies of our systematic review (5) sending emails with the new tool as a survey to the collected authors of experience of in vitro studies, know their comments and

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