Plant sterols used in CholestOff and other supplements were first shown to be effective in cholesterol reducing several decades ago. According to a report published by healthy lifestyle magazine, New Hope Network, sterols have been researched for their cholesterol lowering effects since 1950. Recent studies tout sterols immune improvement capabilities and positive effect has potential cancer preventatives along with its ability to treat benign pros hyperplasia. The prescription of anti cholesterol drugs gained mass foothold when the National Institutes of Health (Nih) lowered the acceptable cholesterol levels. The move drove over 20 million more Americans to anti-cholesterol drugs.
However, adverse side effects attributed to drugs
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The softgel supplement used in the clinical research provided 1.8g of esterified plant stanols and sterols in the 2 softgels that were taken two times before meals. The summary of the results was as follows: Placebo (P<0.01) for non HDL cholesterol (-4.1%, LDL cholesterol (-4.3%) and total cholesterol (-3.5%). The randomized, placebo controlled, double blind study was a collaborative effort between Pharmavite LLC and public health company, Meroux NutriSciences.
The results of the study reinforce previous findings that back clinical data, advocating for the use of dietary supplements alongside making lifestyle changes. In 1999, a study looking at the effectiveness of Reducol and low fat diet in lowering cholesterol levels was conducted by McGill University in Montreal, Canada. In the study involving 32 subjects, patients who took 1.g a day of Reducol branded sitosterol with sterol combination recorded a remarkable LDL reduction of up to 24% compared to a reduction of 9% for those who relied on low fat diet. In the study, no remarkable increases in plasma sterol were recorded, a fact that suggests the sterols were not absorbed.
Citations
PRNewswire: https://www.prnewswire.com/news-releases/new-clinical-study-affirms-plant-sterolstanol-liquid-softgel-supplement-as-effective-means-of-lowering-cholesterol-levels-241457601.html
Nature Made:
A higher level of fats in the body puts the patient at higher risk for Cardiovascular diseases(CAD). The patient's' family has a history of CAD. Her mom and one of her sister have CAD (Lewis et al., 2014, pp. 733-734). The patient states that she has been taking her meds for cholesterol atorvastatin regularly. Her lipase level was 8272 on 11/11/16 and 2829 on 11/12/16 U/L 1069 on 11/13/16 (Ref range 73-393 U/L). Her HDL cholesterol level was 21 ( ref range>49 mg/dl), LDL Cholesterol level 148 ( ref range: <130 mg/dL). Patient statin drug was on hold because it is contradicted on the patient with an elevated level of ALT 80, 61(Ref range 0-50 U/L) and AST 61 on 11/12/16 and 64 on 11/13/16 (ref range 0-45 U/L). The uncontrolled level of could be the cause of concern for stroke or acute myocardial
Dairy should not be a primary food group on the dietary guidelines set by the government because of its many negative effects on human health (given that people care about their health and the health of those around them). Dairy and other animal products are the only food sources which contain cholesterol. Arguments have been made saying that humans need to consume cholesterol in order to have a healthy balance of fats; these arguments fail to acknowledge that our bodies naturally produce all the cholesterol that it needs. And many studies have been conducted to support the theory that consumption of dietary cholesterol overloads arteries and can cause heart disease, artery disease, as well as sudden heart attacks. The Department of Community Health and Preventative Medicine at Northwestern University Medical School worked to interpret an international study based on data from the Food and Agriculture Organization and the World Health Organization. The overall conclusion was that “…dietary cholesterol levels are consistently related to CHD (coronary heart disease) mortality rates” (Stamler). A study conducted by Lena Ohlsson at the Laboratory of Gastroenterology and Nutrition within the prestigious Lund University in Sweden also linked dietary cholesterol and milk fat with artery disease and other metabolic disorders. In short, the abstract of her lab report said that low-density lipoprotein (LDL)—“bad” cholesterol—was found to be directly associated with coronary artery
An increasing number of people are using products to enhance their diets. A recent estimate indicates, “Americans are spending some $6 billion annually on nutritional supplements, and the market is growing by 20% every year” (Zahn, 1997). Of these supplements, the increase in herbal remedy use is most dramatic. Zahn holds that the increase can be attributed to the widely held belief that herbal substances are healthy and harmless because of their natural origins (1997). Unfortunately, research on these supplements, herbal or otherwise, has not transmitted to the public as quickly as the diet enhancers themselves. The phenomenon leaves many consumers misguided by skewed advertising and
In a study conducted in 1985 observing primates, it was determined that the major effect of dietary cholesterol is its LDL raising effects. High intakes of cholesterol increase the number of circulating LDL’s and it can also change its size and composition. [12] It was during this time period that the mechanisms by which SFA are thought to increase blood cholesterol concentrations came about. One mechanism for the increase in LDL cholesterol levels is the suppression of LDL receptor activity. Studies in tissue cultures have shown that increasing the cholesterol content of a cell will down-regulate synthesis of LDL receptors. [13] This will lead to an increase in concentration of blood cholesterol. Another cause for an increase in blood cholesterol concentration through intake of dietary SFA is the composition of the newly secreted lipoproteins. With a high saturated fat intake, the LDL’s become rich in cholesterol esters, leaving the triglycerides in the blood. [14] The use of non-human primates in
High cholesterol is one of the most common diseases that occur in today's society. According to Centers for Disease Control and Prevention, 71 million American adults have high LDL "bad" cholesterol. When cholesterol levels are normal, they normally do not harm the body since cholesterol can be beneficial to the body. However, if excess amounts of cholesterol are in the body, it can become a threat. "Cholesterol is a waxy substance that plays an important role in building cell membranes and sex hormones" (Overview). The certain types of food you consume on a daily basis may affect the cholesterol levels in your blood. There are two types of cholesterol, which is your HDL (high density lipoprotein), "good", cholesterol, and your LDL (low density lipoprotein), which are the "bad" cholesterol. It is critical that an individual maintains his or her cholesterol levels because he or she can increase their risk of cardiovascular disease. LDLs are known to carry cholesterol into your arteries and clog them, which can cause strokes and heart attacks. On the other hand, HDL, help eliminate cholesterol from the arterial vessels and transport it to the liver, which is then defecated with body waste. According to Sroda, an individual's total cholesterol should be less than 200, LDL levels should be less than 130,
Our body naturally produces cholesterol through the liver, we can also obtain cholesterol from consumed products. We need small amounts of cholesterol to produce hormones, bile, and vitamin D. Cholesterol doesn’t dissolve in the bloodstream once it is inside the body. It needs to be carried by two types of lipoproteins called low density lipoproteins(LDL) and high density lipoproteins(HDL). The more cholesterol we consume, the more LDL and HDL we produce. HDL is
“Suppose your doctor got your lab work and said your cholesterol is high with this type of thing it can cause risk of heart attack and cardiovascular disease then he prescribes you a pill called statin. However, ask yourself if the drug is worth it because the statistics only help 30-50 percent of people who consume the drug.” Said Levitin. This quote makes you think about if the solution is really worth it because by a slim chance the drug can help or even cure you disease you contain in your body, and that doesn’t seem right if you are wasting money if you’re not getting help from the drug. This piece of evidence supports my opinion by ten full because you’ll be making big mistake if you buy a drug that may help your disease or disability, and the statistics are not in your favor. However, be smart and ask the doctor any type of questions that may affect you by any
MR. David likewise takes atorvastatin (Lipitor); 10 mg every day, for hypercholesterolemia (hoisted LDL cholesterol, low HDL cholesterol, and raised triglycerides). He has endured this medicine and holds fast to the day by day plan. Amid the previous 6 months, he has likewise taken chromium picolinate,
Bowden and Dr. Sinatra present interesting and valuable information and certainly their individual perspectives concerning the impact cholesterol plays on our health, as individuals, we must determine how we digest this controversial information. I have personally witnessed the adverse effects that cholesterol has played in my father’s cardiovascular health. He chose to consume primarily animal based food with little to no fruits or vegetables, for the majority of his life, and required a quadruple by-pass at the age of forty-eight. Currently seventy-five years old, he has had multiple cardiac arrests, required many additional heart surgeries and now faces the loss of his legs due to ninety-six percent blockage of his femoral artery. I have always believed that cholesterol significantly impacts heart heath so this new information is a bit difficult for me to swallow. I won’t say that the information presented in these videos has changed my viewpoint yet they certain enhance my desire to glean additional information. I appreciated watching both presentations yet I am I not ready to tell my father to ditch his statin medications. The information offered by both medical professional further confirms my decision to eat mostly plant based foods is ideal for my lifestyle and overall well-being.
In 2000, the US Food and Drug Administration issued a health claim which states that consuming foods containing plant sterol and stanol esters along with other low cholesterol and saturated fat foods can reduce the risk of coronary heart disease (Jones, Vanstone, Raeini-Sarjaz, & St-Onge, 2003). Today, many functional foods in the form of margarines, spread, yogurt, and others, have been enriched with phytosterols and advocated as being able to reduce the risk of coronary heart disease. Phytosterols have been known for its cholesterol-lowering effect by blocking absorption of cholesterol in the intestines. However, there are controversies surrounding the efficacy of phytosetrol that are enriched in foods in reducing cholesterol levels. Many studies have also demonstrated the efficacy of phytosterol-enriched foods. Vásquez-Trespalacios and Romero-Palacio (2014) and Amundsen, Ose, Nenseter, and Ntanios (2002) have demonstrated the efficacy of phytosterol-enriched foods in reducing total and LDL-cholesterol levels. However, there are also many studies that show otherwise. For example, Jones et al. (2003) and Weingärtner et al. (2016) have shown that phytosterol-supplemented foods did not have any effect on total and LDL-cholesterol levels. The debate regarding the efficacy of phytosterol in functional foods is crucial as phytosterol-enriched foods can potentially be a solution to a continuous increase in population suffering from cardiovascular diseases. The
Current guidelines state that ezetimibe,is considered the best alternative for LDL reduction and tolerability in statin-intolerant patients and considered an adjuvant in this trial. The primary end point was percentage change from baseline to week 12 in LDL cholesterol. Other end points included measures of safety and tolerability of different doses of AMG145 and AMG145 plus ezetimibe. Other objectives included assessment of the safety and tolerability of 3 different doses of AMG145 and AMG145 plus ezetimibe compared with placebo plus ezetimibe. One hundred sixty patients were randomized into 5 groups, to take AMG 145 as monotherapy once a month at 280mg, 320mg and 420mg, to take AMG 145 420mg once a month with ezetimibe 10mg daily or placebo once a month with ezetimibe 10mg daily. At week 12 the AMG 145 groups had a percent change of blood levels of LDL from baseline from -40.8 % to -50.7 % dose ascending monotherapy and -63.0% with combination with ezetimibe versus -14.8% with combination of placebo and ezetimibe. Reduction in total cholesterol percentwise was from -29.8 % to -37.7 % dose ascending monotherapy and -43.3% with combination with ezetimibe versus -10.7% with combination of placebo and ezetimibe. The overall incidence of all adverse effects was similar among patients receiving
Raisio, a Finnish grain and chemical company, is the proud owner of a product that has been deemed one of the ten most important nutritional innovations in the world (“Benecol®,” 2010). This product is a unique compound composed of plant stanol esters and has been scientifically proven to help lower cholesterol levels in humans. With the prevalence of high cholesterol in the world population and the incidence of mortality associated with a high cholesterol level, it is no wonder that Raisio had a deep desire to share
The good form of this sterol in the body is your HDL, because it picks up all the bad form in your body and store it in the liver to be converted into the bile then exits out.
Annual testing for abnormalities in fasting serum cholesterol, triglyceride, HDL cholesterol, and calculated LDL cholesterol levels (ADA, 2008)
Those on a Mediterranean-style diet are prone to have higher HDL, or “good” cholesterol levels, which help support heart health. Inuit Eskimos, who get plenty of Omega-3s from eating fatty fish, also tend to have increased HDL cholesterol and decreased triglycerides, or fats in the blood. Research studies have shown that fish oil supplements reduce triglyceride levels. Finally, walnuts (that contain high levels of alpha linolenic acid, or ALA, which is type of Omega-3 fatty acid) have been reported to lower total cholesterol and triglycerides in people who have high cholesterol levels.