TBBPA is mainly used as a reactive flame retardant in plastics, paper, textiles, and circuit boards. The general population can be exposed to TBBPA through inhalation, dermal contact, and ingestion of fish and shellfish. TBBPA is absorbed from the gastrointestinal tract, then biotransformed to glucuronides and sulfates, and excreted through feces in animal models (Lai et al., 2015). TBBPA exposure levels in the general population have been examined in several studies. The serum TBBPA levels were below the level of detection (0.03 ng/L) in pregnant Canadian women but detectable in 5 % of the Inuit adults with concentrations up to 480 ng/L (Dallaire et al., 2009). In the United States population, TBBPA was found in approximately 35% of human…show more content… The F0 generation was treated during a premating period of 10 weeks and a mating period of 2 weeks. Only a significant decrease in serum T4 level in both the F0 and F1 generations were observed at a dose of 1000 mg/kg (ECB., 2012). Cope, et al. reported a two-generation reproduction study at oral doses of 10, 100 and 1000 mg/kg BW/day on reproductive, developmental and neurobehavioral study following oral exposure of TBBPA in SD rats (Cope et al., 2015). Consistent with other multi-generational studies, there were no marked effects on various reproductive parameters including time to vaginal opening and anogenital distance, sperm motility, concentration, morphology were observed in F1 or F2 generation. The only observed change was the decrease in T4 level in SD rats exposed to TBBPA at a dose of 1000 mg/kg.
Zatecka, et al. reported a two-generational study to examine the trans-generational effect of TBBPA in CD1 outbred mice (Zatecka et al., 2013). Gestation exposure to TBBPA in drink water (35 μg/kg) to generate F1 offspring. Experimental and control animals of the F1 generation were bred in various conditions to evaluate the trans-generational effect on reproductive system. Significantly reduced testicular weight, increased weights of the prostate and seminal vesicles were observed in the F2 generation from both