Essay On The Pathophysiology Of Osteoporosis

The bones are made up of two minerals, including calcium. Calcium is critical in order to maintain the level of bone mass to support structures of the body. If calcium is truncated in other regions of the body then it will be released from the bones into the bloodstream sending it to the appropriate destination. Bones begin to weaken if an insufficient amount of calcium is not consumed. The body will discontinue absorbing calcium if an abundant amount of calcium is consumed, in which vitamin D aids this process.

Osteoporosis, meaning porous bone from the Greek language, is bone disease that gradually and steadily wears down bone tissue and its living cells. This wearing down will eventually cause the cells of bone tissue to degrade and die, leaving their “scaffolding” to be the only things only bone together. Without living cells to take up a home in this scaffolding, minor injuries such as falls, bumping into objects, and pressure that would normally be completely and would not pose any threat to bone tissue suddenly becomes a real hazard that can easily pose a threat to one’s well-being. Osteoporosis affects a person skeletal system.

Throughout a lifetime, old bone is removed (resorption) and new bone is added (formation) to the skeleton. During childhood and teenage years, new bone is added faster than old bone is removed. Consequently, bone become larger, heavier, and denser. Bone formation continues at a pace faster than resorption until peak bone mass, which is reached around age 30. After age 30, bone resorption slowly exceeds bone formation. In women, bone loss is most rapid in the first years after menopause but persists throughout the postmenopausal years. Based on year 2000 census data, it is estimated that 55% of people age 50 and older have either osteoporosis or low bone mass. The major risk

During the later years, osteoporosis becomes apparent but develops a lot earlier without any warning. The bone has two compartments, which include the cortical bone and the trabecular bone. The cortical bone is the very dense bone tissue that forms the outer shell, whereas the trabecular bone is the

Osteoporosis is when bones become weak or brittle, and have reduced mass. The bones in the human body are constantly renewing themselves, meaning, the old bone is replaced by new bone and then broken down. At a young age, the body makes new bone at a faster rate than it tears down old bone resulting in an increase of bone mass. However, at a older age, the body stops producing new bone and has to rely on the bone mass that was built up at a younger age.

Osteoporosis is a medical condition in which bones become brittle and fragile as a result of tissue loss. Causes of osteoporosis include hormonal changes, deficiency of vitamin D, and, most commonly, deficiency of calcium. Bones affected by osteoporosis are easily fractured, and such fracturing most often occurs in the hip, wrist, or spine. Under normal circumstances, bone tissue is constantly being broken down and subsequently replaced by the human body; however, osteoporosis prevents the creation of new bone. As a result, a net loss of bone tissue occurs since no new tissue is available to replace the old tissue. With age, bone mass loss increases faster than does bone mass creation. There is currently no known cure for the disease. Osteoporosis

Osteoporosis is referred to as the decrease in bone density and mass over time. The interior bones become progressively weaker and can cause a stooped posture. This makes the individual more susceptible to bone fractures. Osteopenia regards a condition where the bone material density is considered lower than normal. This is usually a precursor to the musculoskeletal disorder, known as osteoporosis. The term ‘osteoporosis’ means ‘porous bones’. In this case, bone is a living tissue that is continuously being broken down and replaced. Thus, osteoporosis happens when the creation of bone does not keep up with the removal of the old bone. In this disorder, the bones are diminished and deteriorated in structure. This condition is typically prevalent in older women due to an estrogen deficiency with menopause. The lack of estrogen increases bone resorption and decreases bone deposition. In addition, osteoporosis can occur with atrophy, which is caused by disuse. Additionally, osteoporosis can occur in men due to the aging process as well as patients who have received corticosteroids, which are hormones used to treat inflammatory conditions.

Bones are made up of two layers, the trabecular and cortical layers. The trabecular layer is internal and spongy-like, where the cortical layer is external and more compact. These layers are continuously broken down and reformed by two cells known as

According to Judith (2010), Osteoporosis is a loss of the reabsorption in the bones by way of calcium, plasma, and phosphate. Estrogen production helps bones metabolism by stimulating osteoblastic activity and limiting osteoclastic effects of the parathyroid hormone. It develops when the new formation of bones fall behind in the reabsorption process (Judith, 2010). In simpler terms, it’s a loss of bone mass due to a metabolic bone disorder affected by the rate of bone resorption advances while the rate of the bone formation reduces. According to Judith (2010), the bones end up losing calcium, phosphates and end up brittle making them prone to fractures and further complications (P . 236).

According to the National Osteoporosis Foundation, “About 54 million Americans have osteoporosis and low bone mass, placing them at increased risk for osteoporosis. Studies suggest that approximately one in two women and up to one in four men age 50 and older will break a bone due to osteoporosis.” The bone disorder may be common, but there are many risk factors for osteoporosis. Osteoporosis usually happens with elders, especially in postmenopausal women. According to Human Anatomy and

Background: Osteoporosis is the most common bone disease and is characterized by low bone mass, deterioration of bone tissue and disruption of bone architecture, compromised bone strength, and an increase in the risk of bone fracture. The World health organization (WHO) defines osteoporosis as having a bone mineral density (BMD) at the hip or the lumbar spine of less than or equal to 2.5 standard deviations below the mean BMD of a young-adult reference population. Based on data from the National Health and Nutrition Examination Survey III (NHANES III), NOF has estimated that more than 9.9 million Americans have osteoporosis and an additional 43.1 million have low bone density.2 About one out of every two Caucasian women will experience an osteoporosis-related fracture at some point in her lifetime, as will approximately one in five men.

Throughout life the skeletal system is constantly changing. Bone modeling, formation and growth of bones, occurs from birth to early adulthood resulting in increase in skeletal mass and changes in skeletal form. Naturally the peak bone mass is achieved in the third decade of life, meaning the bones are at their strongest state in human development. Bone remodeling, a response to micro trauma and stress on the bone, is a dynamic process that also occurs through life. Bone is composed of collagen type 1, a protein, minerals such as calcium and phosphate and bone forming cells (osteoblasts and osteocytes) as wells as bone resorbing cells known as osteoclasts. Calcium is a main contributor of bone strength. In fact 99% of calcium is stored in bones and teeth with one percent remaining in the blood. The process of bone remodeling is activated by stressors such as weight bearing and is necessary to maintain bone mass in an adult. It’s a dynamic process in which bone resorption is always

Introduction: Osteoporosis is a disease that disproportionately affects postmenopausal women. It is an important disease for public health to address as it greatly contributes to frailty and risk of injury, largely due to fractures, and the associated burdens on the health care system. Literally translating to “porous bones”, osteoporosis occurs when bones lose their density, and the inner bone matrix becomes much more brittle (Figure 1).1,2 Health adult bones are in a constantly dynamic state, with living cells that multiply to grow and repair bones as we age. Bones structurally consist of a hard, calcified outer layer, and an inner matrix made of collagen and non-collagen proteins.3 Healthy bone mass, and the structure of this inner matrix, is maintained through processes called resorption and remodeling.1 Resorption occurs as some cells dissolve bone matrix for the body to reabsorb and reuse the minerals, and remodeling occurs simultaneously as other cells deposit new bone matrix proteins to replace the dissolved minerals. Each remodeling activity is associated with a slight net loss in bone mass, and as such, healthy adults achieve peak bone density in their early 20s, and bone density gradually declines thereafter.1,4

First of all, sex hormones play a crucial role in osteoporosis. For instance, when females' monthly periods stop, their estrogen levels will drop. Moreover, their bone density will decrease because estrogen (females' hormone) is important to maintain their bone healthy (3). Like females, the level of Testosterone hormone in males impacts the bones health. Second, lack of the calcium and vitamin D in people's daily meals. Calcium and vitamin D are both essential items to support the bone structure. Since the bones consist of calcium and without vitamin D the absorption of calcium will be less than the normal

It is constantly broken down by cells called osteoclasts and built up again by cells called osteoblasts. This process is called bone remodeling, and it continues throughout an individual's life. Normally, more bone is built up than is broken down from birth through adolescence. In the late teens or early 20s, people reach their peak bone mass--the most bone that they will ever have. For 20 or so years, bone gain and bone loss remain approximately balanced in healthy people with good nutrition. However, when women enter menopause, usually in their mid to late forties, for the first five to seven years bone loss occurs at a rate of 1-5% a year. Men tend to lose less bone, and the loss often begins later in life. Osteoporosis occurs when bone loss continues and bones become so thin and their internal structure is so damaged that they break