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Esters And The Process Of Esterification

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Esterification
Esters are the carboxylic acid derivatives most commonly produced by the reactions esterification. The most famous esterification is also called Fischer esterification, which is actually an acid-catalyzed reaction of alcohol and carboxylic acid. In addition to acid, alcohols can react with acyl chlorides, anhydrides, and esters are also formed. U with the reaction of alcohol and acyl chloride, with the ester there is HCl, so in such esterification reactions should be added to the base which will bind the acid produced. As a base it is most often added pyridine. In addition, from one ester, another ester can be obtained by reacting the first ester with the new alcohol that represents transesterification.
Fischer
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Salicylic acid (2-hydroxybenzoic acid) was first discovered acid, Figure 3b) in the middle of the 19th century by converting glycoside salicin into acid form. However, this form was difficult to take orally because it caused irritation in the mouth cavity and stomach, and it was a bad taste. In 1897 this problem was solved by Arthur
Eichengrun synthesizing acetylsalicylic acid (2-acetoxybenzoic acid), form aspirin as we use today [4, 5]. The origin is called "Aspirin®" (a protected name
Bayer) is in three words. A- derives from the abbreviation for acetylation, -spirid from Latin it is called the herbage plant (Spirea ulmaria), and -in is a suffix that was used frequently in names of medicines

Mechanism of action of aspirin
Prostaglandins are local hormones obtained enzymatically from fatty acids.
Prostaglandins are molecules that stimulate inflammation, affect secretion of gastric acid, regulate blood flow to individual organs and perform many other functions. They're messengers molecules because these reactions warn the body that something is wrong. Aspirin works so to block the synthesis of prostaglandins by inhibiting the prostaglandin synthase enzyme (which belongs to a group of cyclooxygenase, abbreviated COX), [9,10]. From
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