Eudragit Polymers Be Selected As A Carrier For Fabrication Of Nannofibers?

The inclusion of nanoparticles into the biopolymer matrix has the dual objective of improving the mechanical properties as well as of incorporating nanotopographic features that mimic the nanostructure of natural tissue (7, 88-91)., the role of the scaffolds is being extended from being a mere mechanical support to include intelligent surfaces capable of providing both chemical and physical signals to guide cell attachment and spreading, possibly influencing also cell differentiation (92) (see also Figure

Many molecules, particularly peptides and polypeptides are physically embedded in polymers to create a complex network of interconnecting pores through which the drug could subsequently diffuse. The pore structure and polymer composition is controlled in order to design systems that release the drug at nearly any rate and for nearly

The research is funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and their research is published in the journal Advanced Materials. Neil Thomas and Dr. Sara Goodacre are leading a team of BBSRC DTP-funded PhD students including David Harvey, Victor Tudorica, Leah Ashley, and Tom

The polymer that I choose is polyethylene glycol (PEG). Polyethylene glycol is produced because of the interaction with ethylene oxide with water, ethylene glycol or ethylene glycol oligomers. Some cons of using polyethylene glycol are hypersensitivity, unexpected change in pharmacokinetic behavior, and toxic side products. PEG is also a laxative that can also be used to prepare the bowels before surgery. PEG is also used to slow the clearing of protein from the blood. This makes medicine last longer in the body. Polyethylene glycol has also been used to help the healing of the spine inn dogs and PEG can also help with nerve damage. PEG is most commonly used with the skin because it has maintains it shape well, it is also pliable so doctors can put it in place before setting it with a green LED light.

Their antiviral, antifungal and antibacterial properties make them efficient molecules for the applications in combating many diseases and as therapeutic agents. In addition, it also act as an anti-adhesive agents against several pathogens indicates their utility as suitable anti-adhesive coating agents for medical insertional materials like catheters leading to a reduction in a large number of hospital acquired infections. Some biosurfactants are suitable alternatives to synthetic medicines and may be used as safe and effective therapeutic agents (Rodrigues et al., 2006).

Electrospinning uses an electric field to control the formation and deposition of polymeric fibers onto the targeted surface or substrate [181-183]. In this method, a polymeric solution is injected with a specific voltage that generates a potential difference between the polymeric solution and the targeted substrate. This lead to the ejection of the polymeric fluid from a tip of the capillary or a spinneret when the electrical charges overcome the surface tension of the fluid. As the solvent evaporates, fibers with diameters ranging from several microns to several hundred nanometers can be formed [184]. The diameter of the fibers can be regulated by modifying the flow rate and concentration of the polymer, and altering the distance

From twelve microsponges formulations, three were chosen to be incorporated in aqueous gel. Microsponges prepared by 2.5 mL of DCM, 1 mL of chloroform or 5 mL of EA were selected and coded as F1, F2 and F3. Microsponges were evaluated for % entrapment efficiency (EE), average particle size (PS), span value (SV), and % production yield (PY). For determination of % EE and quantification of resiquimod in skin and percutaneous penetration samples, two reversed phase high performance liquid chromatographic methods were developed and validated. Differential scanning calorimetry (DSC) was used to evaluate the physical nature of resiquimod in microsponges. For both unincorporated and incorporated microsponges in gels, field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectroscopy (FTIR) were used. The release and drug disposition from microsponges gels were

Chronic effects: mutagenic for somatic cells. May cause damage to kidneys and lungs. And may effect genetic material

Sometimes, the greatest breakthrough originates from something simple. In the case of graphene, the breakthrough started when scientists began to slice graphite, a common substance present in pencil, atom by atom. When it reaches to an atom thick, each single layer is known as graphene. It turns from being a humble pencil lead to a revolutionary material that may earn the title ‘material of the decade’. The properties of graphene are extraordinary, it is recorded as the best electrical and thermal conductor in the world. Even though the material is known to be harder than a diamond, it successfully shocked scientists for its flexibility. These facts sparked the curiosity of scientists and encouraged them to explore more of this material.

In 2004, two scientists prepared the graphene, a single planar layer of graphite, which has a double carbon atoms bonds. Each carbon atom joins itself with three atoms by strong σ covalent bonds, the strong carbon-carbon bonding granted graphene a rigid structure. With four valence electrons, each carbon atom can contribute one unbounded electron to form π bonds above the plane of the carbon sheet. Graphene layers arrange as hexagons and every hexagon is completely surrounded by other hexagons that are packed in a honeycomb crystal lattice as shown in Figure ‎1 3. Their thickness is about one atom thick [6] and their bond-length in the range of 0.142nm[7][8]. Thus, in 1 mm thick graphite, there are about 3 million graphene sheets[9]. The 2010 Nobel Prize in physics has been awarded to the two scientists: Andre Geim and Konstantin Novoselov from University of Manchester (UK) for their research in graphene - discovery. Also, the surface area of the single sheet is 2630 m2/g [10].

Due to outstanding mechanical, thermal and electronic properties, graphene is receiving increased attention by the scientific community. Exceptional properties of graphene are owing to its hexagonal monolayer of honeycomb lattice packed with carbon atoms. The mechanical properties of graphene have been extensively

Navigation of blood vessels is an essential part in reaching a lesion or a vessel segment for treatment. Such task is achieved using an endovascular device. The circulatory system being tortuous, improvements to endovascular devices are being investigated. Here the process involved in improving this medical field was by combining two technologies together: endovascular devices and ionic electroactive polymers (i-EAP).

The development of battery types has been a slow process for many years, with new technology relying on such batteries being produced at a much swifter pace. However, scientists believe that it would be much more convenient and effective to have wearable batteries. Researchers at the University of Manchester have taken on the responsibility of producing new batteries that could be printed on shirts and other articles of clothing. The battery, more officially known as a supercapacitor, is made of an extremely thin material called graphene and can easily be printed onto a variety of fabrics, allowing medical equipment and even phones to remain charged as well as strengthening the fabric due to graphene’s high

Carbon nanotubes (CNTs) are constructed with length-to-diameter ratio of up to (1.32 × 108):1, which is significantly larger than any other material. The radius of nanotube is in the order of few nanometres, while they can be up to 18

Murine calvarial preosteoblasts (MC3T3-E1) were selected as the model cell to evaluate the cytotoxicity of the electrospun fibers. The nanofibrous membranes and films after sterilization under UV radiation were cut into small pieces, placed in a cell culture plate, and soaked in the culture medium (DMEM/F-12