Evaluation Of Chemokine Receptor Cxcr3 Receptor Gene Transcription

1497 WordsJun 13, 20166 Pages
Yahya Bello To test whether chemokine receptor CXCR3 mediates gene transcription Introduction SAA (Serum Amyloid A) function is similar to a C- reactive protein (an annular pentameric protein that is mostly found in blood plasma and its levels rise in response to inflammation. It considered as an acute-phase protein of hepatic origin, which increases following interleukin-6 secretion by macrophages and T cells) but acts as an acute phase protein, which can be used as an indicative, predictive or as a therapy follow-up marker for many diseases such as Atherosclerosis, Rheumatoid arthritis, Crohn’s disease, and diabetes. As the level of the serum increases, the SAA is triggered by physical insults to the host which includes infection, trauma, inflammatory reactions, and cancer (R. Kisilevsky a, 1991). A broad response range is reflected by an SAA gene duplication, which results into a cluster encoding of several SAA variants and by multiple biological functions of SAA. SAA prompted chemokines in degrading enzymes through a Toll- like receptors and it functions as an activator and chemoattractant through a G-protein-coupled receptor. A persistent stimulus in an infectious or inflammatory area, this will cause the liver to produce more SAA, which will become an antimicrobial agent by functioning as a direct opsonin of bacteria (Urieli-Shoval, Linke, & Matzner, 2000). The regulation of innate and adaptive immunity through the helps of SAA benefit the invention of a better drugs
Open Document