Examination Of Biliverdin Ix Beta Reductase

1962 Words Oct 10th, 2014 8 Pages
Examination of Biliverdin IX-Beta Reductase
October 10 2014
Joel Langford It is evident that there are many significant biological syntheses that take place in this world. This includes the synthesis of bilirubin (BR) from biliverdin (BV) with biliverdin IX-beta reductase (BVR). BV is one of three products produced from heme being catalyzed by heme oxygenase. Now, BVR, as seen in Figure 1, is known as an enzyme that catalyzes the reduction of BV’s double bond to a single bond on the second and third pyrrole ring. In other words, BVR reduces BV, which is hydrophilic, using NADPH and yields the product bilirubin, which is hydrophobic (1). The schematic for this mechanism is shown below…
Schematic 1: It is important to note the significant roles BR has in certain biological systems. Once thought of as and antioxidant, BR is now most commonly associated with Jaundice, a disease that results in the yellowish coloring of skin caused by BR not being attached to a transport molecule and being excreted (2). BR is also commonly seen in bruises, it being the cause of the yellow pigmentation. Now, BVR is involved with the redox cycle of this synthetic process that converts the BR, which was converted from BV, back into BV which is done through certain reactive oxygen species. BVR seems to allow the high reactive oxygen species concentration to be overcome by the lower BR concentration which, in the long run, shows that BVR has certain medical and biological…

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