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Exercise Training Case Study

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Behavioural, dietary and physical activity have always been regarded as the first-line lifestyle intervention. From previous epidemiological studies, it is widely known that moderate exercise extends life expectancy and quality by reducing the risk of chronic diseases [56, 67, 68]. Generally speaking, exercise can help to achieve the restoration of body function by improving cardiovascular fitness and muscle function, attenuating the decline in body weight and blunting the pathological level in mtDNA mutations in mice multiple tissues [56]. It was also indicated in one paper that exercise training (ET) is an effective method in improving cardiometabolic outcomes, such as blood glucose and lipid regulation, insulin resistance, blood …show more content…

This systemic mitochondrial rejuvenation through endurance exercise promises to be an effective therapeutic approach to mitigating mitochondrial dysfunction in aging and related comorbidities. It is clear that moderate exercise helps prevent mtDNA mutations from reaching a critical threshold of achieving clinical pathologies, thus it gradually represents a pre-symptomatic therapy for patients who carry polymerase gamma mutations in the future. Several studies suggest that this beneficial effect may not be achieved when animals and human do high-intensity exercise over a long period of time [56] because the high-intensity exercise may impose some potential health and safety concerns, whereas others suggested that compared with moderate endurance exercise, high-intensity exercise may lead to a superior or equal improvement in cardiovascular and metabolic health [69]. So there is an active interest in research involving exercise and its physiological effects that extend from the adaptive responses associated with regular moderate exercise to the tissue damage that follows high-intensity exercise because this area is still in need of further investigations. Although the effect of exercise has been tested in a lot of other tissues, its effects on the pancreatic cell mitochondrial function between exercise and sedentary mice group have not been examined so far, this

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