Experimental Autoimmune Disease Of The Central Nervous System

1549 Words7 Pages
Introduction: Multiple Sclerosis (M.S) is a chronic autoimmune, inflammatory disease of the Central Nervous System (CNS) that leads to a variety of disabilities, including: asthenia, lack of coordination, abnormal vision, cognitive changes, and sexual and urinary dysfunction(1). M.S pathogenesis involves a complex process of the activity of macrophages and micro-glial cells that leads to differentiation of specific neural Th1 lymphocytes (Myelin auto reactive T-Cells) and secretion of pro-inflammatory cytokines in the CNS. Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease, characterized by inflammation of central nervous system (CNS) injury. This disease is an animal model of multiple sclerosis in human (2). In EAE, CD4+ lymphocytes call macrophages to the central nervous system, subsequently they are activated against microglia cells, which lead to demyelination of neurons (3, 4). EAE can be induced by injection of central nervous system proteins, such as basic myelin proteolipid protein derived from CNS proteins, to animals such as monkeys, pigs, rats and mice (5, 6). Recently, the role of Th2 cytokines in therapy and control of EAE as a potential treatment for M.S has been accepted. Following information suggest that immune modulators, especially those that lead to suppress Th2 environment, can be potential treatments for M.S(3). Many studies have shown that M.S is a Th1 lymphocyte-dependent autoimmune disease. There have been significant
Get Access