Experimental Autoimmune Disease Of The Central Nervous System

Multiple Sclerosis (MS) is a neurologic disease that affects the Central Nervous System (CNS) through cellular immune response and the demyelination of CNS white matter (McCance et al., 2014, pp. 630–633). The initial causes of MS are unknown however, it is believed that it could possibly be due to an immune response to an initiating infection or an autoimmune response to CNS antigens on the myelin itself (Brück, 2005) (Miljković and Spasojević, 2013). MS is a result of the degradation of the myelin sheath surrounding neurons and therefore disrupts the transmission of action potentials along these cells. MS can display itself in the form of symptoms ranging from muscle weakness to trouble with sensation and coordination (NHS, 2016). The degradation of myelin leads the body to attempt to remyelinate the neurons, a process that in turn leads to the thickening of the cell by glial cells and this causes lesions to form (Chari, 2007). It is this thickening (sclerae) from which the disease gets its name. Sufferers of MS can either have a relapsing type of MS, in which there are episodes that lead to the worsening of symptoms for a period of time, or a progressive type of MS where symptoms gradually progress and worsen (McCance et al., 2014, pp. 630–633).

Multiple sclerosis is characterized by inflammation, demyelination, and axonal damage in the brain and spinal cord with a loss of myelin that covers the axons. As the myelin sheath regenerates, scar tissue forms, which looks like plaques on magnetic resonance imaging scans. Multiple sclerosis arises when immune-mediated inflammation activates T cells and causes the T cells and immune mediators to cross the blood-brain barriers into the CNS and attack oligodendrocytes (ie, a type of neuroglial cell with dendritic projections that coil around axons of neural cells). When the oligodendrocytes are attacked, the myelin sheath is replaced by scar tissue, which forms throughout the CNS. As a result of damage to the myelin sheath, the ability to transmit and conduct nerve impulses along the spinal cord and in the brain is interrupted, leading to muscle weakness, fatigue, loss of coordination, balance impairment, and cognitive and visual disturbance (DeLuca & Nocentini, 2011). This disease is characterized by unpredictable remissions that occur over several years. During periods of remission, the myelin sheath usually regenerates and symptoms may resolve, but the myelin cannot be completely repaired. As the disease progresses, the myelin sheath is destroyed and nerve impulses become much slower or absent and symptoms worsen. When degeneration exceeds self-repair ability, permanent disability results. There are four defined clinical types of

“Multiple sclerosis (MS) is a disease in which your immune system attacks the protective sheath (myelin) that covers your nerves” (Mayo Clinic). The immune system is a defensive system that protects your body from diseases and illnesses such as parasites and bacteria (Science Museum). Not only does your immune system defend the human body but also the immune system can work against the body, which is known as autoimmune disease. Since the immune system is working against your body to attack the myelin, this creates an opportunity for multiple sclerosis to invade the nerves in the central nervous system (CNS). The myelin within the body acts like insulation to protect and coat the nervous system (National Multiple Sclerosis Society). Once the myelin is eroded, the nerves become exposed which then causes signals to and from the brain to become distorted or irrupted causing a wide range of symptoms to occur (National Multiple Sclerosis Society). The effect of the myelin eroding is an irreversible process (Mayo Clinic). “The damaged myelin forms scar tissue (sclerosis), which

Multiple sclerosis is an unpredictable, crippling neurological disease of the central nervous system, which affects the flow of information within the brain, and between the brain and body. The name is this disease refers to multiple areas of scarring throughout the brain and spinal cord. This scarring is a result of what happens when the body attacks itself. A substance called Myelin surrounds the nerves to help protect them (Healthline.com, 2015). Multiple Sclerosis is thought to occur in a genetically susceptible individual (although there is no evidence to show that the disease is directly inherited) influenced one or more environmental factors. MS is thought to be an autoimmune disease, however others disagree as the target of the immune

Multiple sclerosis, or MS as it is more commonly referred, is an immune mediated disease that involves the body's own defense mechanism, specialized immune cells, that ultimately attacks the central nervous system. Specifically, the myelin protein that coats axons and forms an electrically insulating layer for quicker processing of the nervous system, is attacked by cytotoxic cells that have crossed into the CNS. In a healthy patient, the blood brain barrier cannot be crossed by cytotoxic cells and it is speculated that an environmental component or outside source mediates this crossing. When the myelin is attacked, it forms scars in the CNS, as multiple sclerosis literally translates to “many scars,” which is the direct result of the disease. The scars disrupt the normal nerve impulses that travel through the central nervous system, and can cause a variety of symptoms including loss of cognition, fatigue, or numbness in the body (Evidence).

Multiple sclerosis, also known as MS, is an autoimmune and inflammatory disease that is very painful for both the patient and care giver. In the disease, there is inflammation and neurodegeneration acting at the same time. There is currently no known primary cause of multiple sclerosis. The disease is however characterized by damaged fatty myelin sheaths around the axons of the brain and the spinal cord. Myelin is a mixture of proteins and phospholipids that protects many nerve fibers enabling speed at which impulses are conducted. It is pathologically characterized as the presence of glial scars all over in the central nervous system. The disease was discovered by the French neurologist Jean-Martin Charcot in 1868 when he examined the brain

Multiple Sclerosis is a "chronic disease of the central nervous system characterized by the inflammation and loss of myelin" (Reingold 1). To Clarify, myelin is a white fatty substance that acts as an electrical insulation for nerve fibers in the brain. Moreover, the effect of having this disease in patients causes "Extreme fatigue, weakness, partial or complete paralysis, incoordination, memory loss, impaired sensation, and visual problems" (Reingold 1). I will be stating the many different treatments that scientists have discovered to help reduce a Multiple Sclerosis relapse.

Malik, O., Donnelly, A., & Barnett, M. (2014). Fast facts: Multiple sclerosis (3rd ed.). [Proquest Ebook Central]. Retrieved from http://www.ebookcentral.proquest.com

Worldwide, more than 2.3 million people are currently affected by Multiple Sclerosis (MS). This condition “is a life-long, potentially debilitating disease of the central nervous system (CNS)” (Pasquier, 2014, 537). Specifically, it is a chronic auto-immune disease that attacks the central nervous system. Furthermore, the person’s own immune system does not recognize the neurons and attacks the myelin, and the nerve fibers it covers and protects. The myelin then creates scar tissue which causes damage and keeps the nerve impulses in the neuron from being able to travel to the brain or the spinal cord. If this occurs, bodily functions become difficult or impossible because messages aren’t being delivered to or from the organs back to the CNS.

Results are consistent with the IL2/IL2R pathway in its role of controlling autoimmunity since the IL2/IL2R pathway controls immunity through proliferation and survival of T cells. In addition this pathway maintains peripheral T-cell tolerance, which, when not kept in check by regulatory T cells will result in autoimmunity leading to damage of the myelin sheaths around axons. Reduced function of regulatory T cells has been detected in multiple sclerosis patients1, pointing to reduced function of the IL2/IL2R pathway due to genotypic variation.

This investigation reveals that significant emphasis is laid on the relapses in multiple sclerosis, but relapses do lead to the development of permanent disability. Relapses include flare-ups followed by periods of remissions. These are caused by inflammation that takes place in the central nervous system (CNS), where it causes damage to the myelin sheath, thereby disrupting the nerve impulses

Multiple sclerosis (MS) is a very complex disease characterized by many different pathophysiological mechanisms that play a role in how the disease presents itself and its progression (Miller, 2012). Some mechanisms that play a role in MS are demyelination, axonal/neuronal damage, inflammation, gliosis, etc (Miller, 2012). Among 20-40 year olds, MS is the most common neurological disease (Miller, 2012). There are many different causes associated with MS but the two main causes of MS are axonal injury and oxidative stress and excitotoxicity.

Multiple Sclerosis is a nervous system disease that disturbs the brain and spinal cord (Rolak,2005). Initially affects the myelin sheath, the material that covers and protects your nerve cells. Multiple Sclerosis causes demyelination (Rolak,2005). The nerve damage is caused by inflammation (Rolak,2005). Inflammation occurs when the body’s own immune cells attack the nervous system (Rolak,2005). This can happen in any area of the brain, optic nerve, or spinal cord (Rolak,2005). It is unknown what exactly causes Multiple Sclerosis (Rolak,2005). It is considered to be a virus and environmental factors may also play a role (Rolak,2005). A person’s immune cells begins to attack the central nervous system and degenerate (Rolak,2005).

human MS. In this model, the injection of BM-MSCs improvedthe clinical course and promoted peripheral T cell tolerance tomyelin proteins, thus reducing the migration of pathogenic T cellsto the CNS (Morando et al., 2012; Bai et al., 2009; Gerdoni et al.,2007; Zhang et al., 2005). In this model setting, the therapeuticeffects of MSCs were not likely attributable to graft- or host-driven remyelination, but rather were mediated by an immunemodulatory mechanism guarding the CNS from immune-mediatedinsult (Morando et al., 2012; Rafei et al., 2009). Similarly, BM-MSCs have been reported to have been successfully used in animalmodels of acute disorders, such as stroke or spinal cord injury,while they are disappointingly unable to remedy the neurologicaldeficits when chronic neural damage occurs. These observationssuggest that the immunosuppressive nature of BM-MSCs, whichis substantially increased by inflammatory cues, allows them tomodulate immune response and inhibit inflammation (Uccelli et al.,2011).These findings pose the question of whether the reported ben-eficial effects of BM-MSCs in immune models such as EAE are dueto suppression of the peripheral immune response that damagesmyelin or due to immune-independent mechanisms of action, suchas the direct replacement of the dying cells, oligo/neuroprotection,and/or enhancing endogenous repair. This question is furtherhighlighted by a recent study conducted in a non-immune toxinmodel in which intravenously injected BM-MSCs did

Multiple sclerosis (MS) is a degenerative and potentially debilitating disorder that affects the spinal cord and brain, collectively known as the central nervous system. Multiple sclerosis evolves gradually throughout time and is considered to be auto-immune, which means the immune system mistakenly attacks healthy cells and tissues that are supposed to be within the body. According to Medscape, symptoms consist of, but are not limited to, sexual problems, ataxia (the inability to control certain muscle movements as defined by Tortora and Derrickson), fatigue, and optic neuritis. Multiple sclerosis is characterized into four different types: relapsing-remitting MS, secondary-progressive MS, primary-progressive MS, and progressive-relapsing MS. There is currently no cure for multiple sclerosis, but there are many forms of treatments to help suppress the symptoms and hinder the progression. The Patient Education Institute lists of treatments include prescription medication and healthy lifestyle habits, such as exercising. Steroids are also administered to delay the severity of the attacks. The aforementioned details about the treatments, types, and symptoms of multiple sclerosis are merely a superficial analysis. To fully understand this disease, a more in-depth and detailed focus of its impact within the body is needed.