Explain The Biological Process Of Osseointegration

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The biological process of osseointegration following the creation of an osteotomy site includes blood clot formation and the release of growth factors (BMP’s, VEGF etc.); this is followed by new blood vessel formation (Angiogenesis). The presence of a fibrin scaffold between the osteotomy site and the surface of the implant serves as a transition between the bone marrow (where the osteoprogenitor cells are located) and the surface of the implant, which is a very important factor in the migration of osteoprogenitor cells into the bone-implant interface zone. When the cells get there, they begin the deposition of lamellar bone and then the formation of a more mature bone on the surface of the implant to achieve a good osseointegration. The reason

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