Explanation Of Diagnosis : Neutropenia

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Pathophysiological Explanation of Diagnosis: Neutropenia is the reduction of neutrophils in the blood. Neutrophils are the body’s main defense against bacterial and fungal infections. The normal levels of neutrophils are between 55-70% but in neutropenic patients the count can greatly fall and mask an inflammatory response. The Diagnosis of neutropenia is made by WBC count with differential, but evaluation requires identification of the cause. If fever is present, infection is presumed, and broad-spectrum antibiotics are necessary, especially if the neutropenia is severe. ( Linda Workman, Ignatavicius, Donna,, 2016) (Pagana & Pagana, 2014)

Etiology: Alcoholism, cytotoxic chemotherapy or radiation therapy, Drug-induced neutropenia, Folate or vitamin B12 deficiency, hypersplenism, Infection, Congenital neutropenia, aplastic anemia (Kostmann syndrome).

Signs and Symptoms: Chills, sweating, sores in the mouth, diarrhea, flue like symptoms, abdominal pain and shortness of breath. Sometimes fever is often the only indication of infection due to absence of an inflammatory response at the infection site.

Common Complications: Pneumonia, septicemia, bacterial infections, fungal infections.

Other Medical Problems: Steroid induced diabetes, autoimmune hemolytic anemia, anemia, chronic lymphocyte leukemia, and thrombocytopenia.


Physical Assessment:

Vital Signs: Blood pressure 96/61, Temperature 97.7, Heart Rate 61, SPO2 96%, Respirations 18/min

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