Facial Tumor Disease

Cancer, medically called ‘tumorigenesis’ (Thaker, Lutgendorf, & Sood, 2007, p.430) occurs when cells in the body orient themselves for malignant growth. Such cells show ‘self-sufficiency in growth signals’, are ‘insensitive to anti-growth signals’ and have ‘limitless replicative potential’ (Thaker, Lutgendorf, & Sood, 2007, p.430). Once a particular set of cells become malignant, the malignancy can spread to other set of cells in different organs due to ‘crosstalk’ between the affected cells and their surrounding ‘tissues’ and ‘micro-environments’(Thaker, Lutgendorf, & Sood, 2007, p.430).

Sadly, one in three people, one in four dogs, will face some form of cancer in their lifetime. The hope is that will change one day through the work of many wonderful organizations and initiatives including One Cure. One Cure initiated at CSU, was founded on the principle that cancer is one disease. Cancer is cancer. Because it’s the same disease what is learned in pets being treated for cancer holds promise to also benefit people, and vice versa. This approach is known as comparative oncology and is the core of the One Cure concept. Furthermore, treatment breakthroughs come through collaboration between scientists and doctors who are working with both people and pets. The mission of the CSU Flint Animal Cancer Center is to improve the prevention, diagnosis, and treatment of cancer in pet animals, translating their research and knowledge to also benefit people with

Being ambushed by an abrasion on our skin whether it be a pimple, a scar, or something with greater depth such as malignant melanoma can cause quite the adrenaline rush. Diseases of the integumentary system are just as life threating but can be even more mind boggling than a disease occurring internally. For a person to actually see the change in their skin while taking steps to cure it on their own with home remedies and skin care treatments just to find out that the disease is beyond just a simple “break-out” or rash can cause other problems such as stress and insecurity. The integumentary system fights as a barrier to protect the skin and also excrete waste, diseases sometimes hinder this system from doing its main job; which is defending

Transmissible cancers are rare and only 2 other forms of cancer are known to be transmissible, the canine transmissible venereal tumour (CTVT) and marine bivalve cancer (nature communications). Transmissible cancers act differently to other cancers. This is because transmissible cancers are spread between individuals of a population through direct contact, much like how a disease is spread. Whereas other cancers are caused by a mutation causing uncontrolled cell division resulting in a tumour. DFTD is spread throughout the devils by direct contact, most commonly biting. The cancer is mainly spread during fights for mates, food and land however some are spread during mating itself (pnas). Bites between the devils enable a living cancer cell to be transferred between the individuals therefore colonising another host (UOC). DFTD was found to originate from a female host that carried a mutation in a nerve cell. Once transmitted the cancer cell causes tumours to grow on the face and inside the mouth area of the devil, once they reach a certain size they cause the devil’s to starve to their death due to not being able to eat as a result of the size of the tumour (live science Devilish). DFTD has spread to cover almost all the populations of Tasmania causing the population of Tasmanian devils to drop by 95% since discovering the disease (nature

Cancer occurs when cells in the human body create irregularities and start to duplicate at anomalous quick rates. The outcome is the development of tumors in or on the surface of the body and organs. Tumors might be generous (not destructive) or threatening (harmful). Since ordinary cell improvement and duplication is a moderate procedure which is well controlled, it is evident when cells duplicate so rapidly.

This idea went against all of my previous research, and left me quite puzzled; how could cancer suddenly be contagious and only affecting this one species? My group and I then proceeded to read about the history of the Tasmanian Devil and how it had at one point become extinct in Australia, and only found in Tasmania, hence its name. Through this migration of a whole species and the extinction of all of the devils in other regions, the devils soon got a low genetic diversity. All of the devil's in the region have similar cells, and are practically all related as they all stem from the same original devil and therefore, their bodies are not able to recognize cancerous cells which in turn creates the large scarring and tumors on their

Parvovirus came from felines and did a species jump and mutated to canines. Feline panleukopenia virus (FPV) genetically mutated many times and finally changed the capsid protein which gave the feline virus the ability to cross species and infect canines.

DFTD spreads due to biting between animals during mating or feeding. The cancer cells themselves are the infective agent, as opposed to a transmissible virus that leads to Tumor formation. in the case of the devils (Pearse et al., 2012), the genes that could differentiate between own and foreign cells are so similar between the cancer and host, that the devil’s immune system does not identify the cancer,

Through the selected five articles, a greater knowledge of the impacts and future implications of the infectious disease DFTD was established. The articles states the disease is a fast spreading disease that causes major effects on Tasmanian Devil cells, chromosome and genome structures and due to these impacts there has been a dramatic decline in Devil diversity and population

Malignant gliomas are the most common type of primary brain tumors. As already shown in the Central Brain Tumor Registry of the United States (CBTRUS) report from 1998 – 2002, gliomas account for approximately 80 % of all malignant brain tumors and at least 30 % of all brain and CNS neoplasms (Ostrom et al., 2014). A number of putative risk factors that have been associated with brain tumors have been discussed. However, there is no clear cause for brain and CNS tumors. Less that 1 % are linked to lifestyle or environmental factors (Parkin, Boyd, & Walker, 2011). The only exposure that has been shown to affect glioma risk is ionizing radiation and has been classified as a cause by the International Agency for Research on Cancer (IARC) (Cogliano

Tasmanian devils have been under attack with a deadly disease. The devils facial tumor disease can cause lumps on the devils face and neck. The lumps on the devils face causes them to not be able to eat, breath, or drink anything. DFTD has been around for over 20 years. Devils are also known to carry cancer. The DNA of the devils divides uncontrollably that it can form a tumor. Once they get infected they die between a year. Some of the devils are able to survive but most are not. By 2016 scientist discovered a new illness, they called it DFTD2.

The Tasmanian devils population has decreased by 60% and they could be extinct in 20 to 30 years if they don’t do anything about it.(Yong) This is because of a disease called devil facial tumor disease (DFTD).(Yong) This disease is transmitted by bites or wounds inflicted on another tasmanian devil that has DFTD.(Pearse et a Swift) They think the disease is easily transmitted by the low genetic diversity.(Yong)

A carnivorous marsupial, the Tasmanian Devil, has been suffering greatly from DFTD (devil facial tumor disease) - but why the population has been so susceptible to DFTD is another question. Tasmanian devils have low genetic diversity, and this factor contributes to why DFTD is so immensely affecting this population. The Tasmanian Devil’s low genetic may have been caused by the widespread killing of the marsupial by bounty hunters, leaving the species with descendants from the same small population. This resulting low genetic diversity from not having a very diverse selection of mates leads to small variation in the genes for their immune systems, which may contribute to the rapid spread of

This implies they can pass an assortment of hazardous microorganisms on us, when we get licked on the face.You don't trust us? There are various illustrations when the canines along these lines exchanged tuberculosis on their proprietors. In 2013, kid was contaminated with TBC by family canine. The youngster, who was under 10 years of age, completely recuperated, however the puppy was

causes of Melanoma- Malignant melanoma develops when the melanocytes do not respond to the normal control mechanisms of cellular growth. This often occurs in the melanocytes of a pre-existing mole. The abnormal cell growth within the mole may then invade nearby structures or spread to other organs in the body (metastasis), invading and compromising the function of those structures or organs. the varieties and stages of disease- Cancer may spread from where it began to other parts of the body. The method used to stage melanoma is based mainly on the thickness of the tumor and whether cancer has spread to lymph nodes or other parts of the body. The following stages are used for melanoma: Stage 0 (Melanoma in Situ). treatment options- Surgery