Factors Affecting The Rate Of Protein C ( An Anti Coagulation Factor )

1099 Words Jul 23rd, 2015 5 Pages
○ Factors V, VII, VIII, IX, X, XII.1,16,17
○ von Willebrand factor.16
○ Decreased levels of fibrinolytic protein C (an anti-coagulation factor).16
○ Coagulation changes are most pronounced in the third trimester.16
● Effect on Dental Treatment o The patient’s hypercoagulable state places them at increased risk for thromboembolic disease.17 Because of this, there is an increased risk that the patient may have a thromboembolism while in the dental office. (See the following section titled “Thromboembolic Disease” for additional information.)
Thromboembolic Disease
● Background Information
○ Changes in clotting factors place all pregnant women at increased risk for venous thromboembolism.8
○ During pregnancy, women have a five times increase risk of thromboembolism.17
○ Effects about 1 in every 1000 pregnancies.17
○ Pregnant women are at increased risk of thromboembolic disease because they are in a hypercoagulable state.17
○ During pregnancy, uterine compression of the venous return from the lower extremity leads to venous stasis and predisposes a woman to thrombus formation.17
○ About 0.10 percent of pregnant women form a thrombus. Of these, about 20 percent develop a pulmonary embolism which has a 12 to 15 percent mortality rate.17
○ The risk of pulmonary embolism during the immediate postpartum period is greater than the risk during pregnancy.16
● Effect on Dental Treatment
○ Pregnant women are at increased risk of thromboembolic disease.17 Because of this, they are…
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