Fibrodysplasia Ossificans Progressiva is a Disorder of the Muscle and Connective Tissue

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Fibrodysplasia ossificans progressiva (FOP) is a disorder in which muscle tissue and connective tissue such as tendons and ligaments are gradually replaced by bone, forming bone outside the skeleton (extra-skeletal or heterotopic bone) that constrains movement. It usually becomes evident during early childhood, always starting with the neck and shoulders and proceeding down the body into the limbs.
FOP affects 1 in 2 million people with no ethnic, racial or gender patterns. There are 800 known cases across the globe with only 285 confirmed cases in the United States.
Fibrodysplasia ossificans progressiva is caused by the genetic mutation of a Bone Morphogenic Protein (BMP). BMPs are proteins and are important for the formation of bone and the reconstruction of fractures, and are tied to a receptor called activin receptor type IA (ACVR1). This receptor has been traced back to chromosome 2q23-24. (papers), 2012)
This refers to chromosome number 2 between the bands 2q23 and 2q24, as illustrated in the diagram below. Knowledge about this disease can help to develop a cure. (papers), 2012) Fibrodysplasia Ossificans Progressiva is usually diagnosed when a child is around ten years old and this disease is usually misdiagnosed as malignancy, aggressive juvenile fibromatosis and desmoids tumours. When a patient has surgery to remove the bone from his/her body, the body repairs the area by producing more bone, this happens because BMPs are affected by the disease. Therefore

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