Fluvoxamine Case Study

Decent Essays
Fluvoxamineis an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Serotonin, also known as 5-hydroxytryptamine(5-HT), is amonoamine neurotransmitter with various physiological functions such as mood, appetite, andsleep[1].
In vitro: Fluvoxamine was effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes [1].Fluvoxamine (10 mg/kg) increased [5-HT]ex levels in all brain areas, and also increased [DA]ex levels in the striatum. Fluvoxamine (10 mg/kg) in combination with of quetiapine (10 mg/kg) increased [DA]ex and [5-HT]ex levels in all brain areas compared with baseline. The combination produced a significant increase of [DA]ex levels in the prefrontal cortex and thalamus whereas
Get Access