Fmr1 5-Choice Training Report

7/24-7/26: The syllabus states that we have an update presentation on Monday, so over the weekend I will be working on my presentation for class.

They were subjected to gears or buttons and scheduled reinforcement. The experiment in this chapter deals with a box of rats he receives from one of his colleagues. He wanted to see if he could use those rats to see if he could train them using positive reinforcement. He wanted to see if hungry rats placed in a box could learn to press a lever if they were rewarded with food. The box had a lever on the side that the rats would eventually find and accidentally knock or

Day three of animal testing, all subjects seem to be unresponsive except the Toucan and the Dolphin (don’t even ask how I got it in the lab) are only the only subjects who seem to have no side effects. Good.

Our experiment was simple, yet painful. It involved us pressing a clothespin nonstop, for 3 minutes and 20 seconds. Every 20 seconds, we had to tell our partner how many times we pressed the clothespin. Each person did this 4 times, twice with each hand. One time, we were also listening to fast-paced music, in hopes of distracting us from the pain. The experimental control was a prior experiment. In which we pressed the clothespin like I explained, but without any music. So we kept the clothespin, the people doing the experiment, and allotted time the same during both experiments. Our independent variable was the addition of music (distraction), while the dependent variable was the muscle fatigue in

White Rat: as they began the test with the white rat it seemed to be going in a forward direction, as the wrapped started crawling towards him he showed very little stimulation. But as they introduce the rat the second time and let it touch his hand he withdraws immediately leaned to one side but did not cry this

METHOD: Before the experiment starts, the rat is food deprived for 24 hours. For the extinction procedure the standby switch is placed in the stby mode, in order to prevent the rat from starting first than the experimenter. Next, the power switch is turned to the on position to test the apparatus for proper functionality. Then, the mode switch is set to CRF. Later, the response and reinforcers counters will be set to zero. Also, the room light is turned off, and the desk lamp is set to the on position. After, the rat is placed into the Operant Chamber, and the lid is secured. Later, the STBY switch is set to run. At this point the timer is set to the on position, and

- In addition to this 1 rat, the other rat on S8b schedule is showing steady performance at 55% accuracy with 33% omissions. We also have 6 rats that have reached S7b schedule this week. In addition, we have 4 rats that have been moved on to S6b schedule.

- This week marks 10th week of the Fmr1 rat training and we have 1 rat that has almost reached the end of the challenge trials. It performed on the challenge trial for shorter stimulus duration time - 0.7sec and has performed with 78% accuracy with fewer than 14% omissions. We have one wild type rat that finished the challenge trial series and we are expecting this 2nd wild type to finish soon

Moreover, the range helped me find out that Maria’s rat is smarter. It highlights that her rat showed more improvement than Tran’s did. Also, the boxplot was useful too. It helped me come to a conclusion by showing that Maria's rat started out slower than Tran’s, but then started to improve more rapidly than Tran’s rat.

- We have 1male KO that will finish the challenge series in the upcoming week. We ran the rat on ShortITI-2.5sec challenge trial yesterday. It performed with an accuracy rate of 55% with 33% omissions.

The experiment lasted 15 consecutive days. During the experiment, the rats were placed into 12 identical operative chambers which was used for all behavioral training and testing. Each chamber had an automatic retractable lever

The purpose of this research was to determine if castrated rats are slower in locomotive activities compared to intact rats. Data from these kinds of experiments and research serve useful in for preclinical studies for humans. This research could be used to help in proving things about testicle removal in humans.

The subjects were Sprague-Dawley male rats. Their age is 150 days. The supplier is Harlan Sprague-Dawley. They are maintained on a 12:12 h light/dark cycle and are provided with ad libitum access to food.

When scientists aspire to study a specific trait or genetic mutation, selective breeding occurs to be able to single out the trait and breed it into offspring, This selective breeding is usually inbreeding between siblings up to twenty generations to achieve rats that are almost genetically identical to each other, and therefore will all have the same trait (Hubrecht 47). This gives scientists the advantage of having a steady constant, when otherwise hundreds of variables could affect other species and skew data. These strains of rats have names associated with them and are sent distributed to laboratories when their strain is needed in an experiment. One would think that an animal whose existence is specifically for experimentation, that increased recognition would go into their well-being. According to Bayer scientists in 2015, “91.5% of the total” animals used in laboratory research were rats and mice (Bayer AG). This substantial amount is an overwhelming number, and the percentages are so high due to the lack of regulations. Due to the fact that umpteen rats are used in research each year, it is important that their sacrifice is taken into consideration. They deserve for their legal classification to fall under the “animal” category

- Discovered the main sources of the 60Hz noise induced in the VEP recording; one of the major sources is the behavior equipments in the adjacent room next to the wall on the left side of the surgery table; the other sources includes the CRT monitor, BNC cables and the heating system.