Folic Acid, Or Liver Enzyme Levels After Isotretinoin Therapy

1391 Words Dec 5th, 2015 6 Pages
folic acid, or liver enzyme levels after isotretinoin therapy.9 In the group taking 1 mg/kg/d of isotretinoin, total cholesterol levels were significantly increased after therapy. In the group taking 0.5 mg/kg/d of isotretinoin, there was no significant change in cholesterol. Triglycerides significantly increased in both the 0.5 and 1 mg/kg/d treatment groups after the administration of isotretinoin therapy.9 In Kamal and Polat’s study, the small sample size could have resulted in a type II error.9 Although the length of isotretinoin therapy in this study is similar to that administered in the general population, the “after treatment” lab work was done on only the 45th day of treatment. By doing the lab work only 45 days into treatment, this study failed to evaluate what the levels might be like after a full course of isotretinoin therapy. The researchers controlled for medications and health conditions that might affect the participants’ levels of vitamin B12 and folic acid, but they failed to control for other factors, such as diet and exercise.9 Because certain groups were excluded from this study, the results of the study cannot be applied externally to those groups. One strength of this study is that participants in the control group were matched to reflect the treatment group, which reduces the possibility of confounding variables. One unique characteristic of Kamal and Polat’s study is that it measured the effect of two different dosages of isotretinoin therapy (0.5…
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