Fybrodysplasia Ossificans Progressiva

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History In the year of 1958 Jeannie Peeper was born. The mother noticed that Jeannie had short, crooked toes and was concerned. The doctor didn’t think anything of it and he put braces on her toes and sent them home. When Jeannie’s mother saw red lumps appearing on her back and head she became anxious. She also noticed that Jeannie’s jaw wouldn’t open as widely as her other childrens did when they were her age. Because of this she took Jeannie back the doctor and at the age of four where she was diagnosed with fibrodyplasia ossificans progressiva (Carl Zimmer, 2013). Fibrodysplasia ossificans progressiva is a rare and incapacitating condition of skeletal malformations and progressive heterotopic ossification. It was originally called myositis ossificans progressive (MOP) and was discovered by a French physician, Guy Patin, who came across a patient who had FOP. He described the patient to have “swellings” in his back (History of FOP, 2009). They changed it from MOP to FOP because other fibrous tissues in addition to muscle are replaced by bone. FOP causes excessive bone growth and begins in the early stages of life.

How Is It Acquired?
Fibrodysplasia Ossificans Progressiva is obtained by a mutation on the ACVR1 gene which occurs on chromosome 2. It is autosomal dominant disorder which means it only takes one parent to pass the trait on. In most cases it’s a random occurrence due to mutations during the development of the sperm, egg, or embryo. Another reason it
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