G6pd Research Paper

Fatigue: The growth and development of red blood cells in the bone marrow may be suppressed while having increase in the number of malignant plasma cells, which then cause low levels of red blood cells in the blood. This condition, know as anemia, can result in unusual fatigue or weakness.

The first type of anemia is macrocytic-normochromic. Macrocytic-Normochromic anemia occurs when large stem cells derive into erythrocytes. The erythrocytes are problematic because they also end up being large in thickness and volume. This type of anemia is considered normochromic because the hemoglobin remains its normal size. Macrocytic anemia will happen if DNA is synthesized incorrectly. The DNA synthesizes incorrectly due to a deficiency in either vitamin B12 of folic acid. If there is a deficiency in vitamin B12 then it is considered pernicious anemia, and if there is a deficiency in folic acid then it is considered folate deficiency anemia. The enlarged erythrocytes die off

Anemia is a disorder of the blood. It occurs when your body does not produce enough erythrocytes or red blood cells (RBCs). Without the erythrocytes oxygen can not be adequately delivered to the tissues and organs throughout the body. This will cause you to become weak and tired. A person may also experience headaches, skin pallor, and faintness. Your body may attempt to compensate for these symptoms by speeding up the heart rate and respiratory rate. This is the body’s attempt to return oxygen levels to normal(Thibodeau and Patton, 2005).

The most prominent cause of Iron Deficiency Anemia is bleeding. Blood loss from the Gastrointestinal Tract is a significant cause of anemia for both men and women. When blood is present in excrement, a gastrointestinal problem exists. Many times, people are unaware of these problems with their waste products. When they begin to feel the symptoms of anemia and undergo tests that determine that they are anemic, it begins the process of discovering more health problems. Anemia can serve as the precursor of certain diseases. There are many instances when it is merely a sign of severe disease such as a peptic ulcer disease, gastritis, hemorrhoids, angiodysplasis of the colon, and colonic adenocarcinoma (http://www.physsportsmed.com/issues/sep_96/browne.htm).

Otherwise known as G6PD deficiency, people with an extreme case of this illness would experience hemolytic anemia, fever, and fatigue after eating fava beans or take drugs like primaquine. This is due to the fact that people with favism lack sufficient amount of the enzyme G6PD, which is important for protecting cells from chemical elements that would otherwise destroy the cells. The substances mentioned above act as the catalysts for the production of free radicals (un-paired electrons). As these un-paired electrons seek to pair with electrons in red blood cells with deficient amount of G6PD, it causes the cell membranes to burst. The loss of red blood cells when left untreated can cause the person to have kidney failure, heart failure, and death. As of now, there is no treatment for G6PG

This anemia results in fatigue and a number of the following problems;pain episodes, strokes, susceptibility to bacterial infections, particularly in children, leg ulcers, bone damage, yellow eyes or jaundice, early gallstones, lung blockage, increased infections, kidney damage and loss of body water in urine, painful erections in men, blood blockage in the spleen or liver, eye damage, low red blood cell counts (anemia), and delayed growth.

* Anemia-related fatigue occurs when there is a decrease in red blood cells (RBCs). This happens when myeloma cells replace RBCs in the bone marrow.

This disease is inherited from parents, and it is dominant, meaning only one copy of the gene is needed to develop this disorder. It is extremely rare and it affects less than 0.01% of people of European ancestry. See figure 2 for heredity patterns.

blood disorders, such as hemolytic anemia (the rupture or destruction of red blood cells that lead to a decreased amount of red blood cells in your circulation, which leads to fatigue and weakness)

Congenital dyserythropoietic anemia is a blood disorder r that is inherited and it is also present at birth. Congenital dyserythropoietic anemia is just one of the many types of anemia, which are conditions that affect the red blood cells. When a person has anemia they have a shortage of RBC’s. Red blood cells are important in maintaining homeostasis in the body. The main functions of the red blood cells are to transport oxygenated blood to the tissues of the body. With that being said, when people suffer from anemia do not get the adequate amount of oxygen to the tissues of their body. The symptoms of anemia vary from person to person, some experience weakness, while other are more fatigued (www.ghr.nih.gov). Other symptoms include pale skin, chest pains and tachycardia or fast or irregular heart rate/ beat.

Anemia is a condition in which the concentration of red blood cells or hemoglobin in the blood is below normal. Hemoglobin is a substance in red blood cells that carries oxygen to the tissues of the body. Anemia results in not enough oxygen reaching these tissues.

The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells. Specific manifestations include pallor, headache, palpitations, dyspnea, fatigue, or ankle edema (Porth, 2015). Signs and symptoms of aplastic anemia may include nosebleeds and bleeding gums, frequent or prolonged infections, and pharyngeal ulcerations. Patients with aplastic anemia commonly present with symptoms of pallor, headache, palpitations, dyspnea, easy bruising and fatigue (Porth, 2015). Other symptoms include visual disturbance due to retinal hemorrhage, petechial rashes, SOB with exertion, dizziness (Porth, 2015). Patients with aplastic anemia also present with jaundice and evidence of clinical hepatitis (Porth, 2015). Obtaining work history, solvent exposure, as well as a family, environmental, and infectious disease history (Musser, 2006). The clinical presentation of

MAPT, GRN and C9ORF72 but most of cases are sporadic and 5-10 % are caused by only one of the theses genes (Bertram & Tanzi, 2005).

Your doctor will look for symptoms of anemia and other physical clues that might point to a cause. There are basically three different causes of anemia: blood loss, decreased or faulty red blood cell production, or destruction of red blood cells Complete blood count (CBC), which determines the number, size, volume, and hemoglobin content of red blood cells . Blood iron level and your serum ferritin level, the best indicators of your body's total iron stores . Levels of vitamin B12 and folate, vitamins necessary for red blood cell production . Special blood tests to detect rare causes of anemia, such as an immune attack on your red blood cells, red blood cell fragility, and defects of enzymes, hemoglobin, and clotting Reticulocyte count, bilirubin, and other blood and urine tests to determine how quickly your blood cells are being made or if you have a hemolytic anemia, where your red blood cells .Only in rare cases will a doctor need to remove a sample of bone marrow to determine the cause of your anemia.Medical professionals use medication,therapy, surgery, and

My son Jimmy is now 10 months old. Just recently I’ve found out that he has G6PD deficiency. When my wife found out she was a bit frightened, but after we talked it over with the doctor she found out it wasn’t that bad. Only in severe cases it can lead to kidney failure or even death. It can also cause anemia. Hemolytic anemia is something you would want to avoid.