Gene Therapy And The Treatment Of Alzheimer Disease

Gene therapy is a very controversial topic that has been discussed in the last five years and is being heavily studied to help cure cancer. Gene therapy is a technique aimed at treating genetic disorders by introducing the correct form of the defective gene into the patient’s genome (Dunlop et al., 2010).

When it comes to Alzheimer’s, I know firsthand how it affects individuals and their families. My great grandfather had Alzheimer’s for many years before his passing late last year, at age 92. Alzheimer’s is a disease that many individuals suffer with each year, but yet with all the advancements in modern medicine we still have no cure for it. There are different ways to conquer this disease, understanding the causes, knowing effects, and researching possible treatments.

Alzheimer 's disease (AD) is a progressive degenerative disease of the brain from which there is no recovery. There are three brain abnormalities that are the hallmarks of the Alzheimer’s disease is initially caused by plaques buildup in the brain’s neurons as illustrated in figure 1. The support structure that allows the flow of the nutrients through the neurons gets damaged and ultimately there is loss of connection among the neurons and they die off (National Institute of Health, 2015). This causes the brain tissue to shrinks, which is called atrophies. All this ultimately lead the victim of this disease to face difficulties in governing emotions, recognize errors and patterns, coordinate movement, and remember. Ultimately, a person with AD loses all memory and mental functioning.

Alzheimer's disease is one of the most common causes of dementia. The term 'dementia' describes a set of symptoms, which can include memory loss, changes in mood and problems with communication and reasoning. These symptoms occur when certain diseases and conditions, including Alzheimer’s disease, damage the brain. Alzheimer's disease could be described as a physical disease affecting the brain. During the course of the disease, protein 'plaques' and 'tangles' develop

Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.

Alzheimer’s disease (AD) is a progressive and fatal form of dementia, frequently seen in the elderly altering their cognition, thought process and behavior. AD is reported in about half of patients that have a dementia diagnosis; one study states that about 10.3% of the population over 65 years is affected by dementia with an increase to almost 50% over the age of 8 (Beattie, 2002). Alzheimer’s disease is not a normal part of the aging process in humans, but rather found in a group of diseases that affect the brain leading to a decline in mental and physical control. AD when diagnosed has a very slow and gradual course, initially affecting the individual’s short term memory (Beattie, 2002). Alzheimer’s disease is the 6th leading cause of death, affecting more than five million people in the United States and is also one of the most common forms of dementia. Dementia can be defined as a disorder of progressive cognitive impairment severe enough to affect daily functions of an individual’s life (Fillit, et al., 2002).

Alzheimer 's is a slow and debilitating disease that generates multiple problems with cognitive skills including; memory, thinking and behavior. (MedlinePlus, 2015) It is especially painful for friends and family members who see their loved ones progressively lose their memory and ability to function as they normally have. Symptoms typically develop gradually and progressively get worse over time, becoming severe enough to put the person afflicted with the disease unable to complete daily tasks and placing themselves at risk. (MedlinePlus, 2015) Alzheimer’s is the most common diagnosed condition of dementia. (MedlinePlus, 2015) Sixty to eighty percent of dementia cases are designated as Alzheimer’s. (MedlinePlus, 2015) Although the greatest known risk factor for Alzheimer’s is increasing age, it is not considered a normal part of aging. The majority of those diagnosed with Alzheimer 's are approximately sixty-five and older. However, Alzheimer’s is not just a disease affected by the older age populations. About 5 percent of people with Alzheimer’s experience early symptoms and the onset Alzheimer 's and most often appears in their forties or fifties. As stated above, Dementia or Alzheimer’s symptoms gradually worsen over time. In the early stages, it is common to experience mild memory loss. Eventually, the ability to carry on a conversation is lost. The sixth leading cause of death in the United States is Alzheimer’s. After Alzheimer’s symptoms become publicly

Luckily, there are biotechnology companies trying to solve the growing problems that Alzheimer’s disease is presenting to the public. Despite repeated failures in clinical trials, leading pharmaceutical companies continue to invest time and capital in finding Alzheimer’s disease treatments. 99 percent of therapies in the past decade have come up short. Scientists are bitterly divided on the issue of targeting amyloid to effect the progression of

Alzheimer's is a type of dementia that causes problems with memory, thinking and behavior. It is the most common form of Dementia which is a general term for a decline in mental ability severe enough to interfere with daily life. Alzheimer’s accounts for 60-80% of dementia cases. Based on 2018 Alzheimer’s Association statistics, there are more than 5 million Americans living with Alzheimer’s over the age of 65 (Alzheimer’s Association, 2018). Many scientists state the death rate for heart disease has declined by 11% while death by Alzheimer’s has raised by 123% (Alzheimer’s Association, 2018). It is considered to be the 6th leading cause of death in the United States (Alzheimer’s Association, 2018). Alzheimer’s disease(AD) is an abnormal aging

Alzheimer's Disease is one of the societal issues that Scientists will be able to address. Most Alzheimer's patients have gotten the disease from their parents, meaning, scientists can study the genome of the patients to understand why it is genetic. Alzheimer's is difficult to understand because someone can get the gene even when no one else in their family has it. Studying the genomes of these patients can also give light on why there is Early-onset Alzheimer's and Late-onset Alzheimer's. Through this study and research, scientists can get a better understanding on how to slow down or even cure the disease.

Alzheimer’s disease affects the lives of over 5 million Americans today. The cost that it has placed on the U.S is a staggering $203 million dollars. Researchers have reported that those numbers are expected to triple by 2050. However draining that this disease may seem, the real question is whether there is a solution. To this day there is still no cure to stop or even slow down th progression of the brain disease but there are treatments that help cover the symptoms. While the majority of the people who suffer from Alzheimer is generally over the age of 65, about 200,000, of the estimated 5 million, are in the age range of 30-40.

Ultimately, the path to effective new treatments is through clinical trials (“Medication”). “Future Alzheimer's treatments currently work by temporarily improving symptoms of memory loss and problems with thinking and reasoning” (Mayo Clinic Staff). “Future Alzheimer's treatments are focused on combinations of medications like those used for many cancers” (Mayo Clinic Staff). An ongoing clinical trial conducted by the Dominantly Inherited Alzheimer Network (DIAN), is testing whether antibodies can reduce the growth of beta-amyloid plaque in the brains of people with certain genetic mutations and thereby reduce, delay or prevent symptoms

Alzheimer's Disease is a condition that affects 50% of the population over the age of eighty five, which equals four million Americans each year. It is becoming an important and high-profile issue in today's society for everyone. There are rapid advancements being made in the fight against this disease now more than ever, and the purpose of this essay is to educate the public on the background as well as the new discoveries. There are many new drugs that are being tested and studied every day which slow down, and may even halt the progress of the disease.

1.Preface : Gene therapy, looks all previous fields of cruel edge scientific report, and was the subject of major ethical debate. Gene therapy has generated could be argued further discussion of other medical discoveries in its infancy because of its ability to influence the human genome. There are two types of gene therapy is currently under discussion, gene therapy and somatic cell gene therapy from germ cells. 2. Point of view for gene therapy research:

The first, involving gene replacement, attempts to correct a specific genetic defect linked to a major component of the disease by expressing unmutated gene. In reality, the number of patient whose neurodegenerative disease is linked to a single genetic mutation is quite small, so the impact of this application of gene therapy to neurology is limited. Another goal of gene therapy is to transfer therapeutic proteins to a targeted area of the central nervous system (CNS), not