Genetic, Biological, Chemical Pathways, And Modification Of Cancer Cells Essay

1498 WordsAug 31, 20156 Pages
A cancerous cell must adapt to various biological, chemical pathways, and modify it to impose its malignant behavior in human’s cell. The authors, Douglas Hanahan and Robert A. Weinberg points out six significant variations in cell physiology that leads to the composition of most of these cancerous cell. The cell’s autonomy in growth signals, insensivity to growth-inhibitory signals, circumvent apoptosis, endless replication, angiogenesis sustainability, as well as neighboring tissue invasion along with metastasis are main acquired capabilities of cancer cells. The article’s significance depends on its simplicity to convey information by providing concise methods as to how the cancer cell acquires the capabilities to turn normal human cells into cancerous one. The impersonating behavior of tumor cells result in heterotypic signaling thereupon making cancer cell hyper-responsive to encourage more growth. Furthermore, the article suggests that in 25% human tumor cells, a Ras protein is often found structurally altered. A problem with mutated Ras protein is that it cannot be phosphorylated hence a prolonged signaling is expected. Despite knowing this, there is a limitation as to what other growth factors get deregulated in human tumor. For example, one study found that half of the tumors in human colon carcinomas bear mutant ras oncogenes (Kinzler and Vogelstein, 1996, p. 59). Thus, the researchers theorized that other half of tumor cell carried defects in growth signaling

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