Genetic Disease Is An Autosomal Dominant Neurodegenerative Disorder

Huntington’s disease is a disease with symptoms that appear between the ages of 30 and 50. Symptoms include: the incapability to walk, difficulty in swallowing, contractions of the face, paranoia, and changes in personality to name a few. The disease can last up to 15 years, and it ultimately causes death. Purdy stated that this disease can be thought to be equal to any other impactful genetic disorder or disease. With that being said, Purdy declared that a disease like Huntington’s demonstrates why it is immoral for a mother to conceive when she knows that her child will later be prone to an early death or debilitating symptoms. Purdy states that parents that are risk for Huntington’s disease and other genetic diseases and disorders have a moral responsibility to not have children that will be affected with genetic diseases or disorders. Purdy again refers to the medical advancements that are present that will detect genetic diseases, defects, or disorders. Ultimately, Purdy believes that with the medical advancements that detect genetic diseases, parents should not have children that will be prone to genetic

HGPS is not a genetic disease that can be passed down through family members, because people who suffer from it don’t live long enough to reproduce, or at least not very often. Those who do have a chance to reproduce usually choose not to, because as much as they want a baby and a normal life, they know that they will be gone soon and don’t want them to have to go through that, or have there be a chance that the baby gets the disease too.

It is said that Huntington's disease was first introduced to Australia by a Somerset woman who arrived in Tasmania aboard the "Arab" ship in 1842. She had thirteen children; eight with her first husband and five with her second. Five of the six females and four of the seven males inherited the disease.

You married someone who doesn’t have the disease, but they are recessive. Would you still have children? The possibility of your children getting this disease is a 50-50 chance. It brings a lot of thought to your mind right? The disease I am talking about is Huntington’s disease. This disease causes, clumping in the brain and causes the death of nearby nerve cells. A brain area responsible for coordinating movement, and of the cortex, which controls thought, perception and memory, are most often affected.

4. “Huntington Disease - Genetics Home Reference.” U.S. National Library of Medicine, National Institutes of Health, ghr.nlm.nih.gov/condition/huntington-disease.

An example of a dominant genetic disorder is Huntington’s disease or HD. Huntington’s disease affects the brain and causes the nerve cells in the brain to breakdown. Once the nerve cells are affected, a person’s physical and mental state will start to deteriorate. Huntington’s disease is incurable and affects people from 30 to 50 years old. Once a person has had HD for more than 10 years, the

Huntington's disease is an autosomal dominant disorder, which is found on the # 4 chromosome. George Huntington discovered it in 1872. It mainly has an effect on the nervous system. There are around 210,000 bases between D4S180 and D4S127. The disease itself is found in 2% of people in their childhood, and in 5% of the people they were older then 60. (Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington’s disease is paternally

Human genetics can play a major role in determining ones physical condition. One slight change in a genetic sequence can cause a disorder that can be life threating to the organism. Most of the genetic disorders are caused by recessive allele. In most cases this recessive allele is undetectable due to the disorder not being presented in the physical appearance. Hypercholesterolemia is an example of a human disorder controlled by a single gene. This human disorder causes high levels of cholesterol in an individual due to the absence of the low-density lipoproteins.

The HTT gene codes for the manufacturing of the protein huntingtin. It is not currently known what huntingtin is directly necessary for, but it seems to play a role in the proper function of nerves in the brain. Huntington’s Disease is caused by a mutation in the CAG trinucleotide repeat found inside the HTT gene. In people without the disease, the CAG repeats only about 25 times. People with Huntington’s Disease have anywhere from 35 to 120 CAG repeats within the HTT gene. An abnormal number of repeats forces the huntingtin protein to be formed longer than normal. Pieces of these proteins eventually break off and stick to each other to create clumps of protein that begin to gather in neurons in the brain. Eventually, this leads to total blockage and results in neuron death. As with most genetic tests, the testing for Huntington’s Diseases is about 99% accurate. Almost every patient with over 35 CAG repeats will develop Huntington’s Disease at some point in their lifetime (Huntington

Huntington 's Chorea or Huntington 's Disease is a rare progressive genetic disorder which afflicts roughly 7 out of every 100,000 people in North America (Rawlins, 2016, pp. 144–153). The disease manifests primarily in tissues of the brain, and affects the shutdown of many primary functions including speech, movement, and cognitive abilities. With a strong genetic component, there is a 50% chance of just one parent passing the gene linked with Huntington 's Disease along to offspring; additionally, studies have proven that everyone with the defective gene will eventually develop Huntington 's Disease. Though medications are used to mange some symptoms of the disease, there is no cure, and there are currently no medication options to manage the psychological and physical decline which comes with end-stage Huntington 's Disease.

Genes are gifts, or sometimes curses, given by our parents that not only affects the way we look, but also how we think and act. A genetic disease can be defined as an abnormality in an individual's genome and can vary in intensity from a discrete mutation of a single base in the DNA of a gene to a whole addition or subtraction in a set of chromosomes. Huntington’s Disease is an example of a genetic disorder in which nerve cells in the brain break down over time. It is a problem which occurs in every nation of the world. Passed from parent to child, a mutation in the normal gene is at blame for the serious conditions of this disease. More than 15,000 Americans have

X-linked recessive don’t affect females because females have two X chromosomes. However, females who inherit the mutation will become carriers. If a male inherits the mutation from his mother, he will not have a normal copy of the gene and will develop the condition. When a mother is a carrier of an X-linked mutation, each daughter will have one in two (50%) chance of becoming a carrier and each son will have one in two (50%) chance of inheriting the condition. When a father has X-linked condition, his sons will not be affected because he will pass on a Y-chromosome. However, any daughters he has will become carriers of the mutation. The genetic conditions inherited include Duchenne muscular dystrophy, haemophilia and fragile X syndrome.6

Surprisingly, ethnicity has substantial impact concerning risks, prevalence of Huntington’s does vary with ethnicity, people with African or Asian ethnicity have a 1 in 1,000,000 chance with a prevalence assessed at 0.38 cases per 100,000. Whereas the prospects for Caucasian people are 70 to 100 times higher with about 3 to 7 cases per 100,000. According to Novak and Tabrizi (2010), “The disease occurs in all racial groups but is most common in people of northern European origin. Its prevalence in the Western hemisphere is 7-10/100 000” (p. 1).

A genetic disorder is an illness that is caused by one or multiple abnormalities in the genome. Genetic disorders are not unusual, however when a genetic disorder occurs it usually happens in one and every thousand or million persons. Sometimes genetic disorders can or cannot be heritable, meaning passed down from the parents to their offspring. Often times the parents are unaware that they can carry over a genetic disorder to their offspring. When genetic disorders that does not occur from the parent, it can mean that the cause for the genetic disorder is caused by a new mutation or changes in the DNA. Most cellular structures consist of proteins that carry out to work and to perform life functions. When a gene is disrupted in a way that the proteins no longer carry out a normal function, a disorder can occur.

Deoxyribonucleic acid (DNA) is the body's instruction manual for making you who you are. DNA is a large molecule that is coiled into a double helix. It is responsible for determining the phenotype of an organism. A child can inherit a genetic mutation if just one parent passes along the mutations or faulty gene. This type of disorder called autosomal-dominant inheritance. The examples of autosomal dominant genetic disorders are; Achondroplasia (dwarfism) Alzheimer's disease (mental deterioration, usually strikes late in life) Huntington's disease (mental deterioration and uncontrollable movements; strikes in the middle age) and Hypercholesterolemia (excess cholesterol in blood; heart disease). In addition, there is autosomal recessive; transmission requires each parent to pass on the gene for it to be represented.