Genetic Engineering and Immunotherapy of Cancer
Genetic engineering is a highly controversial but incredibly powerful and significant branch of biotechnology that will heavily impact the future of human life, if we choose to utilize it. Humans have utilized the engineering of life for thousands of years through selective breeding, which has strengthened the traits in plants and animals that are helpful to humans. Even though we as a species have employed this for ages, it was not until recently that the specific mechanisms were discovered and studied. Once Deoxyribonucleic Acid (DNA)* was discovered as the molecule that acts as the blueprint for all living organisms, researchers have been searching for ways to alter it. In the 1960s,
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Cells also contain a gene called Proto-Oncogenes*, which does the exact opposite as TSG when activated and turned into Oncogenes. How and when these genes are switched on and off determine the cell’s growth, and ultimately the development of cancer. If the TSG is switched off, this can cause problems. Furthermore if the Oncogenes are activated, the cells can become antisocial and ignore the tissue growth regulation mechanisms and begin to proliferate uncontrollably. When this happens, it usually forms a tumor*. This structure then continues to grow and mutate, since many regulatory genes and their promoters have been damaged or changed. The tumor is now even more vulnerable to mutation. This can then deactivate DNA repair genes, causing further problems and susceptibility.
Cancerous cells that reach tumor status are able to because they are not recognized by T-Cells* of the immune system. T-Cells are critical for removing harmful or infected cells from the body. T-Cell protein receptors bind to foreign protein receptors expressed on harmful cells to identify the dangerous cells. After identification, the T-Cell destroys the harmful cell. However, since T-Cells can only identify “non-self” cells, they are often unable to target the cancerous cells that are “self”. This allows most cancers to escape detection by T-Cells and proliferate. However, if human T-Cells were made to be able to detect and
DNA are like legos, they work together to build the traits of living things. They are the building blocks of the body. Many scientists today have been figuring out different ways to manipulate, change, add, and subtract genes from the DNA in living things; this is process is called genetic engineering. Some of the living things being experimented on are live people, plants, and animals. Today scientists are debating on the morals of genetic engineering due to what the community thinks of it, because of the christian 's viewpoint of genetic engineering. To some christians it may pose a threat to their, but to others it may be a blessing or a gift. Genetic Engineering is a growing breakthrough in the science community. “Over the last 30 years, the field of genetic engineering has developed rapidly due to the greater understanding of deoxyribonucleic acid (DNA) as the chemical double helix code from which genes are made. The term genetic engineering is used to describe the process by which the genetic makeup of an organism can be altered using “recombinant DNA technology.” This involves the use of laboratory tools to insert, alter, or cut out pieces of DNA that contain one or more genes of interest.”(Pocket K No. 17) Scientist have yet to unlock the full potential of genetic engineering, but the information and the use they have found for it today has reached farther than anyone 's expectations.
Throughout our lifetime we are in constant change, many of those changes are ones that you don’t notice. However permanent we set a change to ourselves, one thing we hardly notice change is our DNA. Just growing recently in popularity is genetic engineering , along with its immense potential which can do very much for us, in the future and today. However, with all the potential that genetic engineering carries many people have begun to resent what genetic engineering could become instead of focusing on the great capabilities, and what lies ahead of its bright future. Regardless of what others believe, Genetic engineering will renovate the way we do things today, genetic engineering is a tremendous step to accept, and without a doubt a step
Genetic engineering is the deliberate modification of the characteristics of an organism by manipulating its genetic material, otherwise known as DNA. Since biochemists Stanley Cohen and Herbert Boyer pioneered genetic engineering in 1973, the process has grown to have numerous applications such as medicine production, for example insulin (Mckinley). However, a main topic of concern is the application of genetic engineering on foods that we eat everyday. By modifying the genetic "blueprint" of crops, it is possible to improve many aspects of agriculture. But with any sort of scientific discovery that allows humans to act as Mother Nature, genetically modifying organisms has been a very controversial topic. Yet our society continues to grow, and the need for the benefits of genetically modified foods continues to grow. Genetically modifying foods should be permitted in our society because it allows larger yields of crops to be produced, produces foods with higher nutritional values, and reduces our global ecological footprint.
Cancer is described as the abnormal growth of cells. Normal cells are replaced with abnormal cells in which their deoxyribonucleic acid (DNA) has been damaged or augmented (McCance & Huether, 2014). Cancer cells with their various DNA changes are characterized by growing uncontrollably, being immortal with an unlimited lifespan
In order to become cancerous a cell has many molecular changes that can occur including: tumor suppressor gene inactivation, oncogene activation, telomerase lengthening, ability to evade apoptosis, and angiogenesis (Mechanisms in Medicine, 2012). There are a few particular
Genetic engineering is a very controversial topic. People either agree with genetic modification, or they don’t. According to dictionary.com, genetic engineering is the development and application of scientific methods, procedures, and technologies that permit direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population. While researching this topic, I learned many interesting facts. I found out that genetic engineering first started in 1973, I did not know it had been around for so long. I learned that two men, Herbert Boyer and Stanley Cohen, were the first people to genetically modify an organism, which was bacteria. Yourgenome.org states that, “Genetic engineering can be applied to
Cancer is ultimately the result of cells that uncontrollably grow and do not die. Normal cells in the body follow an orderly path of growth, division, and death. Programmed cell death is called apoptosis, and when this process breaks down, cancer begins to form a tumor.
DNA can get damaged. If and when this does happen to a normal cell a new cell will repair the damage. If the cell does not repair the damaged DNA cell the damaged cell will automatically die and the new cell will replace its spot. Sometimes the DNA damage is not repaired and the cell will still live becoming an abnormal cell. Abnormal cells can keep multiplying even though the body doesn’t need more cells. Those cells still have damaged DNA therefore the uncontrollable cell growth will keep on repeating. Think of cancer starting as a party. The cells don't want to stop to turn down the music or stop joining the
Cancer is defined by the National Cancer Institute as “the name given to a group of related diseases. In all types of cancer, some of the body’s cells begin to divide without stopping and spread into surrounding tissues.” Cancer can develop at almost any part of the human body and anyone can develop cancer, although risk typically increases with age because most cancers tend to require many years to develop. Typically, human cells tend to grow and divide and ultimately form new cells as the body needs them. When an organisms cells grow old or get damaged, the cells die, and new ones replace them. However when cancer develops, this orderly process gets reformatted. As cells increasingly get more irregular, old or
Instead, the cell goes on making new cells that the body doesn’t need. These new cells all have the same damaged DNA as the first abnormal cell does. Anyone can inherit abnormal DNA, passed on from their parents, but most often DNA damage is caused by mistakes that happen while the normal cell is reproducing. One of the most helpful websites that help us understand cancer is www.Cancer.org. It states, “In most cases, the cancer cells form a tumor. Over time, the tumors can replace normal tissue, crowd it, or push it aside. Some cancers, like leukemia, rarely form tumors. Instead, these cancer cells involve the blood and blood forming organs and circulate through other tissues where they grow” (American Cancer Society). A tumor is an abnormal lump or a collection of cells, but not all tumors are cancer. Tumors that aren’t cancer are called benign. Benign tumors can cause problems; they can grow very large and press on healthy organs and
By definition, a cancer is a disease that is characterized by “controlled growth and spread of abnormal cells,” (Laini, online). According to Laino, cancer forms when there is a growth of abnormal cells. The abnormal cells also known as the cancer cells grow and forms a tumor in which will began to attack nearby body tissues and organs. Depending upon the various types of cancer, the cancer cells attacks different tissues and organs. As the tumor spreads, some
One thing I learned in researching cancer is that in order for cancer to appear in our body it has to avoid being detected by our immune system. The cancer cells have to avoid being detected by the immune system because if they are detected the immune system will try and fight off the abnormality. If your immune system does not detect the abnormality in cells, the cancer cells will grow and reproduce causing cancer to spread rapidly. The cancer cells that are not detected they can create colonies and spread rapidly.
Cancer occurrs by the production of multiple mutations in a single cell that causes it to proliferate out of control. Cancer cells often different from their normal neighbors by a host of specific phenotypic changes, such as rapid division rate, invasion of new cellular territories, high metabolic rate, and altered shape. Some of those mutations may be transmitted from the parents through the germ line. Others arise de novo in the somatic cell lineage of a particular cell. Cancer-promoting mutations can be identified in a variety of ways. They can be cloned and studied to learn how they can be controlled.
With only a 20-year history, genetic engineering is only a young science with much uncertainly relativity compared to other fields. Much of the elements bioengineering studies and experiments, the DNA genome and sequence, are still unknown to the scientific community. Changes in genes greatly transform the condition, structure, and essence of an organism, giving us an entirely different and unnatural creation. Even when the physical effects are barely noticeable or deemed safe and ethical, these modified creations’ effects on the environment are impossible to predict and will only emerge when the damage done becomes evident to the human population. Though a large unknown looms over modifying genes, bioengineering industries insist upon dismissing the scare over genetic foods with the vast potential “miracle” foods can benefit upon human society.
Genetic engineering is an issue that involves ethical, moral and social choices. With breakthrough research of human genetic engineering and experiments in DNA in medicine, pharmacology, and reproductive technology, DNA a deoxyribonucleic acid, that has a self-replicating chromosomes cell that has genetic information that can be used for to divide, reproduce DNA molecules, that has been used in bioengineering for