Genetic Factors And Its Effects On The Silk Road

s symptoms, supported by x-rays and biopsies of the small and large intestine. Tumor necrosis factor alpha, TNFa, a protein released when the immune system is activated, is a major catalyst in the inflammatory process and is believed to play a major role in the pathogenesis of the disease.

In order to assess the genetic similarities and differences between the two inflammatory disorders, the researchers obtained 9339 control samples, 8064 samples from people with type 1 diabetes, and 2560 samples from individuals with celiac disease. They found a total of seven regions of a chromosome were shared between the two (University).

It is an autoimmune condition. It is also inherited and also can be associated with medical conditions.

Medical researchers are in wide agreement that a process called “inflammation” underlies most of the chronic diseases of the Western world. While the inflammatory response helps the body to heal itself and fight off infections from bacteria and viruses, when the condition is present in large amounts over long periods of time, cancer, diabetes, heart disease, and arthritis often result. Chronic inflammation is the body’s self-protective response to environmental threats such as saturated fats, processed foods, a sedentary lifestyle, smoking, and stress.

The traits of this autoimmune situation are recognized to have an effect on the joints via making them swollen, infected, and particularly painful.

Chronic inflammation has been shown through research to be associated with many cardiovascular ailments including high blood pressure and high cholesterol. It may be more effective to treat the inflammation and is causes to reduce a wide range of health problems.

The first risk factor being in people with dysfunction of the autonomic nervous system. A change or disorder in the autonomic nervous system such as low vagal tone or increased sympathetic responses can alter the visceral response.1 Many symptoms outside the intestinal tract and frequent GI problems can be identified as an abnormal autonomic response such as chronic fatigue or fibromyalgia. Other risk factors include smoking and stress in life including poor coping mechanisms for stress. CD is often accompanied but probably not caused by other autoimmune disorders such as lupus erthematosus and fibromyalgia.1 A genetic marker has not been identified but Crohn’s disease frequently occurs with a family history of the disease. Recent research has identified multiple correlations between certain genetic markers and CD but a definitive connection has not been made.

The effects of autoimmune disorders can be devastating to the human body. The most common types of autoimmune disorders often impair the joints, skin, and multiple organs. All of the different varieties of autoimmune disorders affect more than a million people in the United States, while some of the rarer varieties only affecting roughly every thirty people out of ten thousand(Lohr, John Thomas). If people know the effects of having an autoimmune disease they might be able to catch a serious issue before it causes them a lot of pain.

Autoimmune disease often run in families, seventy-five percent of those affected are women (Roddick). This disease is your body destroying itself, and it can affect all parts of your body. It can be caused by so many different things and in most cases a cause is not found. This disorder

CHD is claimed to be 40% to 60% inherited but nothing has been proven till now.

While most detrimental genes would be eradicated through evolution, the genes for autoimmune disorders seem to be increasingly rife in humans. We will first address the persistence of these genes in the context of ancient vs. modern environments and lifestyles. By comparing the frequency of autoimmune-related SNPs between ancient humans and modern humans, we will be able to better understand the rise in autoimmune disease prevalence. If the frequency of autoimmune-related genes has remained fairly constant or increased over thousands of years, it can be inferred that autoimmune diseases were not large contributors to the detriment of human health and were therefore not selected against. Thus, the sudden increase in autoimmune disease prevalence must be related to interactions between these genes and the environment. If this is true, these autoimmune genes would only recently have become candidates to be selected

Inflammation is a kind of protective immune response of body towards the hazardous stimulants like pathogens, irritants or even dead cells. The components of this protective immune response include blood vessels, mast cells , tumor necrosis factor (TNF-α), tryptase, chemokines, reactive oxygen species (ROS), histamine, bradykinin, prostaglandin and leukotrines, interleukin-1. The inflammatory process is associated with stoppage of harmful stimuli, clearance of damaged tissues and repairing of injury. Inflammation is strictly regulated by the body. The extent of this response determines its positive or negative effect on body. Extremely low level of inflammation can’t stop tissue damage where as chronic inflammation frequently becomes the cause of disease itself.

Borges et al. proposes that the presence of TNF- in the lung is able to lead to inflammatory cell recruitment and pro-inflammatory mediator production via the

Moving on, now history. I will start with the Silk Road’s history. The Silk Road started at 200 B.C, and ended in 1,300 A.D. The Silk Road had lots of trade routes, since it was a very long road. Nobody walked the whole road, since it was dangerous and long. Some Of the dangers that were at/on the Silk Road was deserts, mountains, rivers snow, bandits, corrupt officials, wars, no water, no food, injuries, and dead animals.What dead animals means is if a cheetah killed an animal then saw you, it could possibly kill you. The Silk Road was created after the Roman’s seeing China’s silk, and they traded gold for it. Then, the Silk Road was started. An interesting fact is in China, silk was a matter of life and death. Nobody could figure out how

After the completion of the trial period for both of the inflammation inducing methods, researchers harvested the ears and performed real-time PCR on them. This process required dendritic cells and CD4+ cells. In order to isolate the dendritic cells, researchers harvested cells from the bone marrow. The collection of CD4+ cells in the mice took cells from the infected back skin. They then looked at the effect of co-culturing naïve CD4+ cells with the dendritic cells. Isolating the RNA in the CD4+ cells after the culturing period provided the researchers the RNA needed to complete real-time PCR and determined the antiproliferative effect of the treatment with MSCs. In addition, the researchers harvested spleens, lymph nodes and the skin on the mice's back to test with flow cytometry.