Genetic, Life Cycle, And Association With Humans

Malaria is a disease characterized by fever and flu like illness that according to the CDC “if not treated can lead to jaundice, kidney failure, seizures, mental confusion, coma, and death” (CDC p.2. There are four types of malaria: Plasmodium falciparum, P. vivax, P. ovale, and P. malariae with the most common type being plasmodium falciparum. (CDC p.1) ).. This disease can only be transmitted by an interaction of blood as the parasite lives in the red blood cells of the infected host individual. This can be due to blood transfusions, sharing of syringes or by its common vector, the Anopheles mosquito.Because of its vector being a mosquito malaria is common in areas with warm temperatures and causes the most damage in poor developing

Malaria infection is caused by parasitic protozoan plasmodium. Several species of malaria parasites exist but the most fatal known is plasmodium falciparum. It enters the liver and replicates itself by getting into the red blood cell and ripping its way out when fully matured. It was once thought that the US military got close to completely eradicating the vector mosquito through DDT (dichlorodiphenyltrichloroethane) and the parasitic plasmodium with vaccines until they discovered that both are capable of mutating and gained the ability to be resistant to any chemicals scientists could produce (Horizon, 2005).

In the article” When mosquitoes were killers in America” by Lauren Tarshis, there is evidence that discussed how mosquitoes were far more than a nuisance. The article talked about the symptoms of having malaria. Tarshis said,”Those who become sick get high fevers, bone - rattling chills, and painful muscle aches.” It must have been very painful for people in the olden days who had malaria. The current generation is very lucky because there are medicines that reduce pain. Malaria is a deadly disease caused by mosquitoes sucking blood and transferring the blood to another human's body. Tarshis talked about how many people die in a year due to mosquitoes. The article says” In this way, bite by itchy bite, 212 million people are infected with malaria

Malaria, on the other hand, was far off more deadly then Yellow fever for it consisted of parasites (Malaria). An engineer once quoted “If we could control malaria, I would be less anxious about other diseases. If we cannot control malaria, our mortality is going to very heavy” (American Canal Construction). Consequently, these infections developed in mosquito salivary glands as well and reproduce in the liver (Malaria). Above all, this incubation period could last for months to a year at a time (Malaria). When the parasites leave the liver they reenter the bloodstream where they are able to infect red blood cells to reproduce once again until the cell bursts (Malaria). As a result, it caused anemia and jaundice from the lack of blood cells (Malaria). Other symptoms include seizures, confusion, coma and death (Malaria).

It is caused by a parasite that infects certain mosquitos that feed on humans. People infected with malaria usually suffer from high fevers, shaking chills, achy muscles, headaches, tiredness, and flu-like illness. It may also cause jaundice and anemia. The malaria parasite is found in the red blood cells of a person which means it can be transmitted through blood transfusions, organ transplants, or the shared use of needles syringes contaminated with blood. Malaria is not contagious; it cannot be transmitted from one person to another. Some parasites can remain dormant in the infected person’s body for up to four years after they are bitten. When the parasite comes out of hibernation and begins to invade the red blood cells, the person will become sick.

Brian, G, Y., Greenwood, D, A., Fidock, Dennis, E, K., Stefan, H, I. Kappe, P., Alonso, L., Frank, H and Collins, P (2008) “Malaria progress and prospects for eradication.” Journal Clinical Investiment. 118: 1266-1276.

Mosquitoes pass malaria to humans through their salivary glands. Once the parasites have entered the blood stream, they go to the liver. In the liver they mature and undergo reproduction, forming merozoites. These merozoites enter the blood stream and inject themselves into red blood cells. Once inside the blood cells, they reproduce rapidly and within forty-eight to seventy-two hours, the blood cell bursts, releasing hemoglobin into the blood stream. It is the destruction of these blood cells and the hemoglobin released into the blood stream that actually causes most of the symptoms.

According to the book, the doctor and his crew of medical professionals learned information about malaria at a lake called Zancudo Cocha, which means “Lake of the Malaria Mosquito”. The word “Malaria” actually can be traced back to Italian roots named mal aria, or bad air. It is caused by the anopheles mosquito, which often had a needle that is infested by parasites. When the anopheles mosquito hits a blood vessel and began extracting blood from the target, the parasites traveled through the bloodstream, which is a part of the cardiovascular system, and found a home at the liver. They would then multiplied and return to the bloodstream to destroy red blood cells, causing fever and chills. Even though there is no effective protection against bug bites, the most effective treatment for most forms of malaria would a synthetic pill called chloroquine.

There have been many attempts at preventing malaria, none of which have been very successful. These have usually involved protecting human beings from mosquitoes, the dreaded carriers

Malaria is a parasite that attacks the red blood cells in the body, some effects of Malaria are chills, headache, muscle aches, tiredness, nausea, vomiting, and diarrhea.

Malaria or other similar diseases like malaria has been recognized and encountered by humans for more than 4,000 years. Malaria is caused by the genus Plasmodium parasites, which enter the human body and are transmitted to people through the bite of a mosquito infected with the parasite (Q&A, Malaria). Once the parasite enters the human body, the parasites multiply in the liver and then infect red blood cells. The malaria parasite was first discovered on November 6, 1880, by a French army surgeon named Charles Louis Al phonse Laveran. While stationed in

Anytime after the host has been bit by an infected mosquito they could start experiencing symptoms. The most common early stage symptoms are head and back ache, rising fever, nausea, and vomiting. After the early stages of the virus the host will stop having symptoms or they will enter the period of intoxication. This stage of the virus is the most severe and potentially fatal lasting three to nine days. At this point the host’s liver and kidneys have already entered degeneration. The new symptoms are jaundice, black vomit, and bleeding of the organs. These symptoms kill within seven to ten days of entering the intoxication stage. The main cause of death by this virus is fatal liver damage which causes bleeding of the organs. Bleeding of the organs causes black

The life cycle of the malarial practice consists of a motile non sexually reproductive form termed a sporozoite making its way into the hosts blood stream via being bitten by a mosquito seeking a blood meal. From here it travels into the liver cells where it reproduces asexually to produce merozoites which infect red blood cells and metabolise haemoglobin. At this stage the parasites reproduces asexually to produce more merozoites which infect more red blood cells. At this stage some of the merozites develop into gametocytes which are immature gametes. When a mosquito bites the infected individual the gametocytes are taken up with the blood meal. In the mosquitos gut the gametocytes develop into mature gametes where they form a zygote -which is motile- that migrates to the salivary glands of the

About 3.3 billion people, that is about half of the world’s population are at risk of contracting malaria (figure 1). Every year there are 250 million cases of malaria, and nearly 1 million deaths. That amounts to 2,732 deaths per day. Out of those million people that die every year, 800,000 of them are African children under the age of 5. To control malaria three actions need to be taken: insecticides need to be used to decrease the vector population, people have to be educated as to how to prevent the vector from reproducing, and anti-malarial drugs need to be distributed. To understand the vector and what the vector is, scientists had to first discover what the parasite was and how it worked. It was not until the year 1880 that French Physician Charles Laveran discovered that Malaria was caused by a protozoan in the genus Plasmodium (Malaria, 2013)

Every year some people died by infection caused by malaria. This infection is transmitted for parasite Apicomplex phylum of genus Plasmodium. Has a lot species of Plasmodium (approximately 150 spp) but that infect human although just only four (P. ovale, P. malariae, P. vivax and P. falciparum) and the last its evolves with the several forms that impair lung, kidneys, spleen and brain. Recent year some human case of P. knowlesi the primate specie were reported. The challenge of malaria disease is evolve the immunologic response of host and diverses strategies of parasites such as evasion mechanism, with capacity for exposure outside proteins with high variability genetic for enhance the scape.