Genetic Linkage Analysis Of Alzheimer's Disease

The call came at 9:05 p.m. on January 20, 2004. Mom had just finished telling the news about the girl's grandfather. He had Alzheimer's Disease and was not doing well at all. The ruling was that he probably would not make it through the night. She knew exactly what the news was the moment her mom said, "No." After the news came, the decision was made they would leave the next day to attend the funeral.

There are two types of Alzheimer’s, early onset and late onset, which both have genetic components. Alzheimer’s disease was named after Alois Alzheimer in 1906 when he had discovered changes in the brain tissue of a woman who died unusually from mental illness. Alzheimer’s is ranked as the 6th leading cause of death in the United States. Familial Alzheimer’s disease commonly known as, Early Onset Alzheimer or eFAD is a form of Alzheimer that is usually detected between the ages of 30-60. Familial Alzheimer is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills. Familial Alzheimer’s symptoms may include; movement difficulties, sense of smell, word finding, vision and spatial issues, times and places confusion,

Alzheimer’s is a form of dementia that causes memory loss, thinking, and behavioral issues. Nearly 5.4 million American’s are affected by Alzheimer’s. People who are affected begin with early-onset Alzheimer’s. One will experience symptoms such as confusion, mild memory loss, and speaking issues. The inheritance pattern of early-onset Alzheimer’s is autosomal dominant inheritance. This means that if you inherit the abnormal Alzheimer’s gene from a parent, you are likely to get the disease. Even though Alzheimer’s is a somewhat common disorder, the inheritance pattern of late-onset Alzheimer’s is still unknown. Although, scientists believe genetic, environmental, and lifestyle factors play a role in a person’s risk for developing the disease.

This investigation studies the question: To what extent is Alzheimer’s disease hereditary? To come to a conclusion, seven pieces of research were analyzed regarding their implications on the genetic and environmental factors impacting the etiology of Alzheimer’s. Specifically, four genetic factors were evaluated: the influence of Beta Amyloid Plaques, alcohol dehydrogenase in relation to mitochondrial function, specific Loci, and a twin study to determine relative heritability. The results of these studies indicate a high degree of heritability and genetic factors in Alzheimer’s disease with recognition, to a certain extent, of the relative influence of environmental factors.

This article is about the prevention of the Alzheimer’s risk. Alzheimer disease is also called senile dementia. It is a disease where people lost their memories. This research was done at UCLA Medical Center and University of Pittsburgh. The researchers gathered the participants to do experiment on whether the physical activities benefits to reduce the Alzheimer’s risk. According to the article, the outcome of the experiment showed that increase in physical activities related with larger brain volumes. “Individuals experiencing this brain benefit from increasing their physical activity experienced a 50% reduction in their risk of Alzheimer's dementia.” The researchers actually prove that if you increase your physical activity, then there is

A. This is a picture of my grandparents, they lived very happy and exciting lives. But, after their retirement something changed with my grandmother- she was unable to recognize the face of her husband, whom she had met when she was only 16 years old.

Alzheimer’s disease (AD) is a disease that slowly and progressively causes memory impairment. It will eventually inhibit abilities, such as language, planning, and perception. AD is prevalent in individuals with Down syndrome (DS), a condition where those affected had acquired three additional chromosome 21 before birth (emedicinehealth, 2014). Michael Rafii, director of the Memory Disorders Clinic at UCSD, says that “people with Down syndrome represent the world 's largest population of individuals predisposed to getting Alzheimer 's disease” (Hamilton, 2014). There is no cure for either, and scientists are still lacking the knowledge of a complete story.

When a person has a certain gene mutation they are a lot more likely to have Alzheimer’s disease.

An aspect of aging that I have often grappled with is the increased incidence of dementia and Alzheimer’s disease that we have seen in the last 20 years. I remember vividly, as a psychiatric nurse that started my mental health in an inpatient geriatric facility, we often had patients that were admitted in our facility that either suffered from bipolar, schizophrenia and lastly older people that were depressed either due to loss of a spouse and were grieving.

Alzheimer’s disease is a brain disease the slowly destroys the patients memory and as well as their thinking skills. Alzheimer’s disease is one of the 6th main causes of death. (3,6) Dr. Alois Alzheimer; whom is the one Alzheimer’s disease is named after, noticed in 1906 changes in the tissue of the brain of a female who apparently died of an unusual mental illness. (3) During Alzheimer’s neurons in the brain will eventually lose the ability to function and communicate with one another, the neurons will then eventually die. The parts, in which are affected during this time begin to decrease in size. Alzheimer's disease is a Dementia. (3) Dementia is the great loss of cognitive functioning. Dementia is a group of symptoms, not the disease itself. Some of the cognitive functions a patient, lose their ability to think, remember, and a sense of reasoning. Scientists are not yet sure of the causes of Alzheimer’s disease. Many experiments have been done and many hypotheses have been tested pertaining this subject. There are also different stages of Alzheimer’s. (2) One of them is Early-Onset Inherited Alzheimer’s disease. This particular stage has the strongest supporting data on its causes. The data includes that the mutations dealing with Alzheimer’s disease have been discovered in majority of the patients with Early-Onset Alzheimer’s. (1) Studies show that that in those dealing with this particular stage, the mutation is the leader of the overflowing production of a specific

Similarly, another study focusing on several families with EOAD identified a locus on chromosome 14 that is linked with Alzheimer’s disease, which was shown to be an autosomal dominant trait (Schellenberg et al., 1992). Figure 3 illustrates the map of the chromosome 14 markers. D14S43 was found to be a strongly positive marker in chromosome 14 for EOAD (Schellenberg et al., 1992). This illustrates that, although chromosome 21 if often the main focus of AD researchers, chromosome 14 also plays a large role in the development of the disease.

I also described my grandmother. She still suffers from Alzheimer’s disease. According to the video, head injuries and high blood pressure may promote the disease. In fact, I am concerned about the genetic aspect of Alzheimer’s disease. Also, I am concerned that my mum will get it because her mother has it. I hope that we have a mental health long life.

Alzheimer Disease (AD) falls under the list of DSM yet the studies show such a common thread of the symptoms showing up in old age. Is it natural to become more forgetful and have less reasoning skills as you get past a certain age bracket or is AD a serious mental illness that we can prevent through intentional strategic changes in the lives of people?

Alzheimer is sex-linked disorder dealing with the early-onset Alzheimer and with the late-onset Alzheimer. The

I enjoyed reading your post and found your question to Del intriguing. I hope you don’t mind me commenting on your post.