Genetic Modified Potatoes Vaccines Based for Hepatitis B

Vaccines have been used to prevent diseases for centuries, and have saved countless lives of children and adults. The smallpox vaccine was invented as early as 1796, and since then the use of vaccines has continued to protect us from countless life threatening diseases such as polio, measles, and pertussis. The Center for Disease Control and Prevention (2010) assures that vaccines are extensively tested by scientist to make sure they are effective and safe, and must receive the approval of the Food and Drug Administration before being used. “Perhaps the greatest success story in public health is the reduction of infectious diseases due to the use of vaccines” (CDC, 2010). Routine immunization has eliminated smallpox from the globe and

No antibacterial compounds are available resistant to this disease but genetic engineering has developed the first trees to resist this devastating disease and increased the consumption level. Specific foods have been developed to correct malnutrition problems. To this end, plants have been modified to provide increased and more stable quantities of essential amino acids, vitamins, or desirable fatty acids. For example, golden rice has been genetically modified to increase beta-carotene content which may help to overcome the severe vitamin A deficiencies that cause blindness and iron. Plants can also be genetically modified to grow well in areas of low production potential. For example, two researchers in Mexico inserted a gene from a bacterium into papaya and tobacco to produce acid-tolerant crops. The crops thus secrete citric acid from their roots by combining with toxic metals which in turn making the soils accessible to protect the tropical forests which contain most of the world’s species of plants and animals. Genetic engineering also helps to decrease or eliminate the allergenic proteins that occur naturally. For example, it has been already used to reduce the levels of major allergen in rice and peanuts. Genetic engineering brings closer the prospect of commercial production in plants of edible vaccines and therapeutics for preventing and treating human diseases like cancer and diabetes. The genetically derived vaccines are potentially

The severity of complication range from mild discomforts to death. According to the CDC, 2014 “approximately 15%–25% of people with chronic Hepatitis B develop serious liver problems, including liver damage, cirrhosis, liver failure, and liver cancer”. It is estimated that nearly one million people in the United States (US) have chronic HBV and approximately 3,000 people die yearly from HBV liver related problems. Since the introduction of the immunization in 1990 there has been more than a 80% reduction in the number of HBV cases here in the US. Globally, approximately 350 million people are estimated to have chronic HBV and there are an estimated 620,000 contributory

I believe the biggest dilemma for organizations that have serious regulatory issues is the potential that these regulations will affect profit or make these businesses unappealing for new entries. In Borden and Cooper’s 2002 case research journal, Jay mentioned the average industry yearly turnover rate was 35-40% and Hepatitis B vaccinations cost $180 per person. Taking this into account, 35-40% of their employees per year will need to be replaced and will require a $180 vaccination to conform to OSHA requirements. This would be a very costly regulation that would affect the company's ability to make a profit and stay in business. I also believe this regulation and others like it could affect entrepreneurs considerations to open new businesses

The idea of changing natural processes to produce an “ideal” crop raises concern amongst environmentalists. Extracting bacteria from soil and inserting it into an entirely different species may appear unethical because of the changing of natural processes. Genetic engineering promotes producing a type of crop that is not susceptible to pests, but carries the risk of decreasing genetic variation (Green Peace). Once a crop is perfected, farmers then mass produce that specific crop, and the different variations of the crop are lost (Green Peace). Another concern regarding the use of the Bt protein is the increased risk of allergies (Smith). The transgenic protein comes from bacteria in the soil, and thus raises the concern of allergic reactions to the corn. Consumers are worried that the cry protein injected into Bt corn could have allergies unknown to them because of the cry protein’s characteristic of an extended digestion time. Consumers are also skeptical that genes of this antibiotic resistance could somehow be introduced to other bacteria in the soil, and possibly infect consumers with this bacteria. A major ethical concern of genetically modified crops, specifically Bt corn, is the lack of knowledge of the long term effects these crops have on humans and other organisms. Consumers are uninformed about the

After China developed a new type of potato that utilizes a technique for growing seed potatoes, the United States sought to make this variety better. After rounds of testing and development, the United States refined the Chinese variety of potato making the plants grow more rapidly, which shortens the time taken to produce crop. Also, the variety features virus resistance with the ability for the crop to be easily grown indoors. In October 1995, the first seed potato production was sent and tested in space

Genetic engineering techniques have been applied to various industries, with some success. Medicines such as insulin and human growth hormone are now produced in bacteria, experimental mice such as the oncomouse and the knockout mouse are being used for research purposes and insect resistant and/or herbicide tolerant crops have been commercialized. Plants that contain drugs and vaccines, animals with beneficial proteins in their milk and stress tolerant crops are currently being developed

Many Americans consume thousands of pounds of genetically modified foods every day. Throughout the 21st century, genetic engineering tremendously impacted new research in pharmaceutical and forensic science. During that time, it also revolutionized the food in America and many other countries around the world. Using Recombinant DNA biotechnology on crops and farm animals helps improve nutrition and quantity of foods. However, crops that are altered with hybrid genes can also contain chemicals harmful to humans. By using developed biotechnology, scientists are able to inject viruses and bacteria into the embryos of plants to produce genetically modified crops (). The same is applied for transgenic farm animals to increase the size of the

    The development of recombinant DNA techniques have allowed desired genes to be inserted into a plant genomes resulting in plants that are totally different to the parent plant. The first genetically modified plant-antibiotic resistant tobacco and petunias-were produced in 1983, but it was until 1994 that US markets saw the first genetically modified species of tomato, approved by the Food and Drug Administration (FDA). Since then, several transgenic crops have received FDA

The development of genetically engineered foods began in the 1900s, and has been in United State markets since 1995 (Bredahl 18). The most widespread genetically modified foods are oil, maize, cotton, and soybeans (Cunningham 11). Transgenic foods were products created to increase benefit and lower prices (Whitman 2). Genetically modified foods are essential to enrichments of crops (Tan 3). It helps reduce the use of herbicides and pesticides in plants, enhances taste and quality, lower maturation time,

Many people today are often amazed by the amount of nutrition and health information required for humans. The constant stream of genetic modification of food can be confusing. Genetically modified (GM) foods are plants and animals that have had their genetic makeup artificially altered by scientists to make them grow faster, taste better, last longer and to provide more nutrients. Scientists make these alternations by transferring genes from one organism into another in order to change the condition or character of the receiving organism. This process is known as biotechnology or genetic engineering (GE), and it has revolutionized the way that agriculture is practiced in many parts of the world. Researchers are now able to use GE

The symptoms start appearing after two to five weeks of infection. The main symptoms are nausea, vomiting, diarrhea, low fever, rashes, loss of appetite and yellowing of skin (jaundice), abdominal pain. Diarrhea occurs in case of children. No specific treatment is there. Patients need adequate rest and proper nutrition. If skin becomes yellow then the patient needs a blood test or a liver panel test. If a person vomits for a long period amount of time, they get dehydrated; then, only then, hospitalization is needed. Patients should drink a plenty amount of water, or fluids. He or she should take food, which does not cause any harm to the liver. Patients should avoid tea, coffee or any alcoholic beverages, which causes harm to liver. He or she takes adequate rest. He should not take any medicine which causes harm to liver. If patient is confused about taking medicine then he or she should consult a doctor. Techniques for growing HAV in cell culture have made it possible to generate sufficient amounts of virus for vaccine production. Several inactivated or live attenuated vaccines against hepatitis A have been developed, but only four inactivated hepatitis A vaccines are currently available internationally. All four vaccines are similar in terms of efficacy and side-effect profile. The vaccines are given parenterally, as a two-dose series, 6-18 months apart. The dose of vaccine,

The potato seems to us today to be such a staple food that it is hard to believe that it has only been accepted as edible by most of the Western world for the past 200 years. Our story begins thousands of years ago, in South America—Peru,

In less wealthy countries, kids stand in line for hours to get shots that treat infectious diseases that have the potential to kill. But what if the kids could eat dinner and be safe from those diseases for years after they ate a meal? Anti-cholera potatoes are genetically modified potatoes that contain the fluids that prevent cholera. Sometime in the future, there is a possibility that shots and treatments will be a thing the past. All you will have to do is eat a potato, and for the rest of your life, you wont have to worry about getting cholera. There are some drawbacks in this though. For example, when the plants spread pollen, the pollen will carry the gene the gene that makes the food medicated. If the pollen spreads, the gene will spread causing the natural potatoes to become medicated. This could cause people who didn’t want the medicine to take it without realizing it.

The coding region of the gene is usually fused to a promoter, most commonly used is the 35S promoter from cauliflower mosaic virus (CMV), in order to promote higher expression levels. (Snow et. al, 1997) The popular method for genetic engineering of crop plants is natural gene transfer via an Agrobacterium tumefaciens vector, a bacterium normally found in soils. The transfer-DNA (T-DNA) vector is made by inserting the desired gene fragment in between specific 25bp repeat domains in the bacterium. The vector is then inserted into the Agrobacterium and "the virulence gene products of Agrobacterium actively recognize, excise, transport, and integrate the T-DNA region into the host plant genomes." (Conner et. al, 1999) The amount of DNA transferred is only about 10kb and the nature of the gene is usually well understood. The expression of the gene introduced can also be controlled by adding additional sequences that might allow the gene to be constitutively expressed, expressed only in certain cell types, or expressed as a result of different environmental changes. This method of gene transfer, however, will only work for the natural host range of the bacterium and therefore other methods are used for additional crop plants. Such methods are uptake of naked DNA by electroporation or particle gun bombardment. The use of genetic markers, as mentioned previously, allows for the preferential growth of cultures that contain the new genetic