Genetic Risk And Outcome Of Psychosis

There are multiple examples of the media’s negative depiction of schizophrenia. One such example is the case of Vince Weiguang Li. Li, a paranoid schizophrenic, believed that he was hearing the voice of God, telling him that a man next to him on the bus, Tim McLean, was an alien that would kill Li and others if he was not killed immediately (“Canada Cannibal”, 2008). Li then stabbed McLean, decapitated him and removed his internal organs, and remained on the bus during a 3 hour police standoff (“Canada Cannibal”, 2008), before being subdued by police. In the article “Canada Cannibal” (2008), Li is identified as a paranoid schizophrenic at the start of the second paragraph, immediately after graphic descriptions of the McLean incident, therefore causing the reader to associate the violence described with schizophrenia. Another example of this is the article “Daughter Suffering Schizophrenia Charged With Killing Mum” (Marcus, 2013), where schizophrenia is directly connected with violence, in this case, murder. By including the fact that the daughter is schizophrenic in the title of the

2b) The authors provided the reader a lot of information on the topic. Each topic was very well explored. A lot of different information on different but similar studies. The authors seemed very knowledgeable on the topic. This article lacked a few things. A clear research question and a hypothesis. The paragraphs were not clear and consist, I felt that I had to dig to get certain information. The paper was very wordy, which made me have a hard time understanding the substance.

The methods used to obtain these results were: From this text of the article I conclude that the

I do not believe the article can be improved upon. It has statistics and studies proving the point it was trying to make. It also does not make fake or biased claims and has a very precise assessment.

Ethically there was concern, that the level of deception involved, could have caused detriment to future patients, since the embarrassment from the initial study had a direct affect on the judgements of genuine patients. The reliability of these results may be questioned, as the participant numbers were relatively small; however they were valid as the results showed a strong correlation from each of the hospitals investigated. Rosenhan’s studies have been a catalyst towards further research into schizophrenia, especially since they were ecologically valid.

The scientific interpretation of schizophrenia was one that supported a physical basis which was attributed to an imbalance in the cognition of humans. The goal of natural science aimed in finding rational, scientific causes, that would lead to biological

1. The extent to which these factors cause schizophrenia is till widely debated and is a controversial topic till date.

This essay will discuss whether schizophrenia is genetically inherited disorder. There will be an understanding to what schizophrenia is with a brief description in the introduction. This essay will also talk about weather schizophrenia is genetically inherited or weather it is a biological (Inherited) disorder. It will also include weather schizophrenia is cause by other factors such as social factors, environmental, pre natal, childhood and neurobiology. The essay will also state weather schizophrenia is caused by a combination of the two.

What are the main concepts presented in the article? What information is the author using, and what is its relationship to the main issue? Does the information used appear relevant, significant, valid, and sufficient for the conclusions being drawn? Do you have enough information to determine whether the information is relevant, significant, and valid?

I am in agreement with your process of critical appraisals; identifying the steps in the research process, determining the strengths and weaknesses in the studies and evaluating the validity and credibility of the studies seem to be the root elements of critical appraisals. I appreciated the scholarly article you chose linking depression and mortality among diabetes mellitus patients, particularly because of the straightforwardness of the article. it seemed the conclusion and points of the article were straight forward and the article was easy to understand. If I could suggest any addition, it would be a way to verify the credibility of the study. maybe in this study in particular there is not much incentive for lack of credibility, but in

Schizophrenia is a universal mental illness which is both complex and devastating. Schizophrenia generally begins in the early stages of life and may lead to lifelong disabilities (Moritz, 2010). The context of this paper shall include an introduction on schizophrenia as well as the reasoning this discipline was chosen. It will include a critiqued research study that will explain how the research was presented. The primary focus on the research study will be a literature review, the methods used, the results found, and a presented discussion.

1. In general it is a concern when the only dependent variable in a study is a constitutive gene KO, since constitutive KO makes it impossible to be certain that an adult phenotype is a direct function of gene deletion, versus the result of developmental issues caused by the gene deletion. Normally, I would suggest this weakness is fatal for such a high impact journal as Mol Psychiat. However, since the author's are modeling a developmental disorder like schizophrenia, perhaps this can be salvaged if the authors can link the KO to developmental changes related to schizophrenia. For example, is the hyperactivity phenotype absent prior to adulthood, consistent with the developmental phenotype in other animal models of schizophrenia? Also, it would be appropriate for some sort of direct rescue experiment to be performed (ie returning gene function or receptor stimulation to the specific brain region and restoring function).

In that sense it seemed as instead of an objective overview of facts presented in the studies, I felt the author handpicked the studies to reassert his claim.

After careful review of this article, I came to the conclusion that the authors did present a very well-balanced summary based on the current knowledge about schizophrenia. It did not appear that there were any hidden issues, ethical or not, and it did not appear that there was any bias in the article.