George Mackaness: The Inactivation Of Macrophages

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George Mackaness coined the concept of macrophage resistance and activation in the beginning of the 20th century. He showed that the “inactivation” of macrophages had a lot to do with the pathogen-host interaction. In other words, substances in their respective microenvironments could influence macrophages to attain a particular phenotype (7). This eventually becomes significant when studying cancer and the microenvironment associated with it. One of the most important milestones in the study of macrophages was the their identification as sources of cytokines.
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